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Scott M. Schuetze

osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma . Cancer 1998 ; 82 : 1288 – 1295 . 23. Winkler K Beron G Delling G . Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based

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Mod C. Chandhanayingyong, Nicholas M. Bernthal, Piti Ungarreevittaya, Scott D. Nelson, Sant P. Chawla and Arun S. Singh

, and GCDFP-15. This specimen was sent for fluorescence in situ hybridization analysis and showed an EWSR1 gene rearrangement. Based on these results, the diagnosis of Ewing sarcoma was made. Figure 1 (A) An anteroposterior plain radiograph of

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Carol D. Morris

-term complications of individual and collective therapies emerge. This article summarizes the current treatment paradigms for the 3 most common sarcomas of the pelvis: osteogenic sarcoma, Ewing's sarcoma, and chondrosarcoma. The unresolved issues in the management of

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Rashmi Chugh

are sarcomas, specifically osteosarcoma, chondrosarcoma, and Ewing's sarcoma (EWS). Survival has improved for osteosarcoma and EWS, with cure rates increasing almost 4-fold (∼ 15%–60%) over the past 30 years, as multidisciplinary management has

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Julie R. Heitz, Mintcho E. Mintchev and Joseph W. Howells

Introduction: Although it typically presents as a cancer of the long bones in Caucasian boys, Ewing sarcoma may rarely arise in the soft tissue of older females. This family of small, round, blue cell tumors share distinct chromosomal

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Borislav Hristov, Ori Shokek and Deborah A. Frassica

. Proc NY Pathol Soc 1921 ; 21 : 17 – 24 . 5. Angervall L Enzinger FM . Extraskeletal neoplasm resembling Ewing's sarcoma . Cancer 1975 ; 36 : 240 – 251 . 6. Ambros IM Ambros PF Strehl S . MIC2 is a specific marker for Ewing

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J. Sybil Biermann, Warren Chow, Damon R. Reed, David Lucas, Douglas R. Adkins, Mark Agulnik, Robert S. Benjamin, Brian Brigman, G. Thomas Budd, William T. Curry, Aarati Didwania, Nicola Fabbri, Francis J. Hornicek, Joseph B. Kuechle, Dieter Lindskog, Joel Mayerson, Sean V. McGarry, Lynn Million, Carol D. Morris, Sujana Movva, Richard J. O'Donnell, R. Lor Randall, Peter Rose, Victor M. Santana, Robert L. Satcher, Herbert Schwartz, Herrick J. Siegel, Katherine Thornton, Victor Villalobos, Mary Anne Bergman and Jillian L. Scavone

the disease. 2 Primary bone cancers demonstrate wide clinical heterogeneity and are often curable with proper treatment. Osteosarcoma (35%), chondrosarcoma (30%), and Ewing sarcoma (16%) are the 3 most common forms of bone cancer. Various types of

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J. Sybil Biermann, Douglas R. Adkins, Robert S. Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad III, Deborah A. Frassica, Frank J. Frassica, Suzanne George, Kenneth R. Hande, Francis J. Hornicek, G. Douglas Letson, Joel Mayerson, Sean V. McGarry, Brian McGrath, Carol D. Morris, Richard J. O'Donnell, R. Lor Randall, Victor M. Santana, Robert L. Satcher, Herrick J. Siegel, Neeta Somaiah and Alan W. Yasko

. Osteosarcoma (35%), chondrosarcoma (30%), and Ewing's sarcoma (16%) are the 3 most common forms of bone cancer. Malignant fibrous histiocytoma (MFH) and fibrosarcoma of the bone constitute fewer than 1% of all primary bone tumors. Chondrosarcoma is usually

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Jorge Casas-Ganem and John H. Healey

Marina N Gebhardt M Teot L Gorlick R . Biology and therapeutic advances for pediatric osteosarcoma . Oncologist 2004 ; 9 : 422 – 441 . 4 Marec-Berard P Philip T . Ewing sarcoma: the pediatrician's point of view . Pediatr Blood Cancer

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David M. Thomas and Andrew J. Wagner

of the oncogenic PAX3–FOXOA1 gene product, and in Ewing's sarcomas, which are highly sensitive to IGF1R inhibition in vitro, especially in combination with conventional chemotherapy. Other sarcoma subtypes overproduce IGF2, which can result in