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Robert E. Glasgow, David H. Ilson, James A. Hayman, Hans Gerdes, Mary F. Mulcahy, and Jaffer A. Ajani

United States between 1991 and 2006, the death rate from esophageal cancer in men has increased. This is likely attributable to an overall increase in the incidence of esophageal cancer, 1 which is driven by the profound rise in the incidence of

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Kwang-Yu Chang, Jang-Yang Chang, Joseph Chao, and Yun Yen

, 2008 . CA Cancer J Clin 2008 ; 58 : 71 – 96 . 3. Koshy M Esiashvilli N Landry JC . Multiple management modalities in esophageal cancer: combined modality management approaches . Oncologist 2004 ; 9 : 147 – 159 . 4. Rosch T

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Keyvan Moghissi

Although surgery still holds “the highest place” in treatment of operable esophageal cancer, photodynamic therapy (PDT) represents an effective, minimally invasive treatment option in selected patients, declared Keyvan Moghissi, BSc, MD, MS, FRCS

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Rosalyn A. Juergens and Arlene Forastiere

Edited by Kerrin G. Robinson

laparoscopy for staging esophageal cancer . Ann Thorac Surg 2007 ; 83 : 2000 – 2002 . 5. Medical Research Counsil Oesophageal Cancer Working Group . Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised

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Alfredo A. Santillan, Jeffrey M. Farma, Kenneth L. Meredith, Nilay R. Shah, and Scott T. Kelley

, 2007 . CA Cancer J Clin 2007 ; 57 : 43 – 66 . 3. Kelsen DP Ginsberg R Pajak TF . Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer . N Engl J Med 1998 ; 339 : 1979 – 1984 . 4

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Prajnan Das, Norio Fukami, and Jaffer A. Ajani

incidence of esophageal and gastric carcinoma in the United States . Cancer 1998 ; 83 : 2049 – 2053 . 6. Botet JF Lightdale CJ Zauber AG . Preoperative staging of esophageal cancer: comparison of endoscopic US and dynamic CT . Radiology

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The UNMC Eppley Cancer Center at The Nebraska Medical Center

Upper gastrointestinal (GI) tract cancers originating in the esophagus, gastroesophageal (GE) junctions, and stomach constitute a major health problem worldwide; esophageal cancer is the eighth most common cancer worldwide. An estimated 16,470 new cases of and 14,280 deaths from esophageal cancer will occur in the United States in 2008. Risk factors associated with development of esophageal cancer include age, male gender, Caucasian race, high body mass index, Barrett's esophagus, and history of gastroesophageal reflux disease. Important updates for the 2009 guidelines include a new page on “Principles of Best Supportive Care” that gives specific recommendations for esophageal cancer best supportive care throughout the guidelines.

To view the NCCN Clinical Practice Guidelines in Oncology on Gastric Cancers, please visit the NCCN Web site at

For the most recent version of the guidelines, please visit

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Presenters: Crystal S. Denlinger, Kristina A. Matkowskyj, and Mary F. Mulcahy

For the treatment of gastric and esophageal cancers, recent studies have demonstrated robust findings for new drugs that, as a consequence, are becoming FDA-approved and added to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines

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Thomas Schmidt, Florian Lordick, Ken Herrmann, and Katja Ott

Functional imaging based on PET in esophageal cancer is mainly engaged to provide additional important information beyond standard staging techniques, such as endoscopy, endoluminal ultrasound, and multidetector CT. The most frequently used

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Raymond Jang, Gail Darling, and Rebecca K.S. Wong

origin, cellular characteristics, and responsiveness to treatments. This article addresses 3 contemporary questions in the decision-making process regarding the multimodality treatment of esophageal cancer with curative intent: whether patients with