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Davide Mauri, Antonis Valachis, Nikolaos P. Polyzos, Lamprini Tsali, Dimitris Mavroudis, Vassilis Georgoulias and Giovanni Casazza

P reclinical studies show that bisphosphonates may have antitumor activity in addition to their ability to reduce osteoclast-mediated bone resorption. 1 These effects include prevention of tumor cell adhesion to bone and consequently prevention

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Siyang Leng, Yizhen Chen, Wei-Yann Tsai, Divaya Bhutani, Grace C. Hillyer, Emerson Lim, Melissa K. Accordino, Jason D. Wright, Dawn L. Hershman, Suzanne Lentzsch and Alfred I. Neugut

morbidity of bone disease in these patients, guidelines from NCCN, ASCO, International Myeloma Working Group, and European Myeloma Network all recommend use of the bisphosphonates zoledronic acid and pamidronate in patients receiving primary MM therapy. 2

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Richard L. Theriault

1997 ; 89 : 309 – 319 . 31 Roodman GD . Biology of osteoclast activation in cancer . J Clin Oncol 2001 ; 19 : 3562 – 3571 . 32 Mundy GR Yoneda T Hiraga T . Zoledronic acid and other bisphosphonates: Impact on the bone

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Joanne Mortimer and Mary Mendelsohn

with the guideline recommendations regarding the use of intravenous bisphosphonates in women with metastatic bone disease. Given the importance of bone-directed therapies in decreasing the incidence of skeletal-related complications in breast cancer

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John Charlson, Elizabeth C. Smith, Alicia J. Smallwood, Purushottam W. Laud and Joan M. Neuner

receiving intravenous bisphosphonates at intervals less than 90 days were excluded. Medicare files from 2 years before until 6 months after AI initiation were the source of cohort members' demographic data, outpatient and inpatient diagnoses, and

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Kathleen Harnden and Kimberly Blackwell

Bisphosphonates are an integral part of treatment for bone metastases in many malignancies, including breast cancer. Bone metastases can have devastating consequences, including severe pain, fractures, hypercalcemia, and spinal cord compression

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Azeez Farooki

York City, who served on the NCCN Bone Health in Cancer Care Task Forces in 2008 and 2012. Bisphosphonates and denosumab have been extensively studied both for prevention of bone loss due to cancer therapies and for prevention of skeletal-related events

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Noopur S. Raje, Andrew J. Yee and G. David Roodman

Bisphosphonates Bisphosphonates, such as pamidronate and zoledronate, play a fundamental role in minimizing and managing bone-related complications in MM. 14 , 15 Bisphosphonates are drugs that share a phosphorus-carbon-phosphorus backbone and accumulate in the

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Mohamad A. Hussein

lesions of multiple myeloma: a phase III, double-blind, comparative trial . Cancer J 2001 ; 7 : 377 – 387 . 31. Djulbegovic B Wheatley K Ross J . Bisphosphonates in multiple myeloma . Cochrane Database Syst Rev 2001 ; 4 : CD003188

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Charles P. Borden, Charles L. Shapiro, Maria Teresa Ramirez, Linda Kotur and William Farrar

the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer recommendation that all patients diagnosed with skeletal metastases receive bisphosphonates. The cancer program at OSUCCC uses a variety of tools for process