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What Constitutes Quality of Life? Perspectives of Adolescents and Young Adults With Advanced Cancer

Jane Hinkle, Lori Wiener, Andrea Altschuler, Katharine E. Brock, Mallory Casperson, Chun R. Chao, Lauren Fisher, Lawrence H. Kushi, Joshua R. Lakin, Anna Lefebvre, Corey M. Schwartz, Dov M. Shalman, Catherine B. Wall, and Jennifer W. Mack

Background Adolescents and young adults (AYAs) with cancer have unique needs and priorities, in part due to the disruption that cancer poses to their age-appropriate development. Like patients of older ages with advanced cancer, AYAs identify

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Communicating with Patients on Treatment Options for Advanced Disease

Lillie D. Shockney and Anthony Back

. Shockney discussed the challenge of talking with patients with advanced cancer and suggested ways in which such conversations can facilitate decision-making and enhance quality of life. This task requires providers to be open yet delicate with patient and

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Development and Validation of 11 Symptom Indexes to Evaluate Response to Chemotherapy for Advanced Cancer

David Cella, Sarah K. Rosenbloom, Jennifer L. Beaumont, Susan E. Yount, Diane Paul, Debra Hampton, Amy P. Abernethy, Paul B. Jacobsen, Karen Syrjala, and Jamie H. Von Roenn

Overview R ecent guidance from the FDA discusses patient-reported outcomes as end points in clinical trials. 1 Using methods consistent with this guidance, the authors developed symptom indexes for patients with advanced cancer. Input on the

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Functional Impairment, Symptom Burden, and Clinical Outcomes Among Hospitalized Patients With Advanced Cancer

Daniel E. Lage, Areej El-Jawahri, Charn-Xin Fuh, Richard A. Newcomb, Vicki A. Jackson, David P. Ryan, Joseph A. Greer, Jennifer S. Temel, and Ryan D. Nipp

Background Measurement of functional status is recommended for all patients with advanced cancer, particularly older adults, 1 , 2 but little is known about functional status among hospitalized patients with advanced cancer and its relationship to

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Phase II Trial of Symptom Screening With Targeted Early Palliative Care for Patients With Advanced Cancer

Camilla Zimmermann, Ashley Pope, Breffni Hannon, Monika K. Krzyzanowska, Gary Rodin, Madeline Li, Doris Howell, Jennifer J. Knox, Natasha B. Leighl, Srikala Sridhar, Amit M. Oza, Rebecca Prince, Stephanie Lheureux, Aaron R. Hansen, Anne Rydall, Brittany Chow, Leonie Herx, Christopher M. Booth, Deborah Dudgeon, Neesha Dhani, Geoffrey Liu, Philippe L. Bedard, Jean Mathews, Nadia Swami, and Lisa W. Le

advanced illness, especially in advanced cancer. 5 – 10 As a result, ASCO clinical practice guidelines recommend routine EPC using dedicated palliative care services for patients with advanced cancer. 11 Despite this evidence, routine EPC has not been

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Primary Palliative Care Improves Uptake of Advance Care Planning Among Patients With Advanced Cancers

Michael G. Cohen, Andrew D. Althouse, Robert M. Arnold, Douglas White, Edward Chu, Margaret Rosenzweig, Kenneth J. Smith, and Yael Schenker

for caregivers. 8 Thus, ACP remains an important aspect of care for patients with advanced cancer. 4 , 9 , 10 Despite the acknowledged importance of ACP, data consistently show that ACP often occurs late in the course of a patient’s disease or not

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Associations of Skeletal Muscle With Symptom Burden and Clinical Outcomes in Hospitalized Patients With Advanced Cancer

Emily van Seventer, J. Peter Marquardt, Amelie S. Troschel, Till D. Best, Nora Horick, Chinenye Azoba, Richard Newcomb, Eric J. Roeland, Michael Rosenthal, Christopher P. Bridge, Joseph A. Greer, Areej El-Jawahri, Jennifer Temel, Florian J. Fintelmann, and Ryan D. Nipp

function and increased mortality. 2 , 13 However, data are lacking to understand how patients’ muscle mass and radiodensity are associated with their symptom burden and healthcare utilization. Hospitalized patients with advanced cancer represent a group

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Phase I Clinical Trial of Bendamustine and Bevacizumab for Patients With Advanced Cancer

Apostolia M. Tsimberidou, Alexandra M. Adamopoulos, Yang Ye, Sarina Piha-Paul, Filip Janku, Siqing Fu, David Hong, Gerald S. Falchook, Aung Naing, Jennifer Wheler, Adoneca Fortier, Razelle Kurzrock, and Kenneth R. Hess

the studies of bendamustine in solid tumors, an investigator-initiated study of the combination of bendamustine and bevacizumab was conducted in patients with advanced cancer. The rationale for this first-ever clinical trial combining bevacizumab and

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External Validation of Risk Factors for Unplanned Hospitalization in Older Adults With Advanced Cancer Receiving Chemotherapy

Mostafa R. Mohamed, Kah Poh Loh, Supriya G. Mohile, Michael Sohn, Tracy Webb, Megan Wells, Sule Yilmaz, Rachael Tylock, Eva Culakova, Allison Magnuson, Can-Lan Sun, James Bearden, Judith O. Hopkins, Bryan A. Faller, and Heidi D. Klepin

the current analysis was to (1) externally validate the identified risk factors in an independent cohort of older adults with advanced cancer, and (2) explore additional risk factors associated with unplanned hospitalization in older adults with

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Changes in Prognostic Beliefs of Patients With Metastatic Cancer and Their Association With Changing Health Status

Isabella Gupta, Eric Andrew Finkelstein, Semra Ozdemir, and Chetna Malhotra

Background Prognostic beliefs of patients with advanced cancer have been examined extensively. 1 – 5 Existing research consistently notes the high prevalence of inaccurate prognostic beliefs, 4 revealing a misalignment between patients