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Scott V. Bratman, Kathleen C. Horst, Robert W. Carlson and Daniel S. Kapp

ultraviolet radiation is the predominant environmental risk factor for skin cancers, including cutaneous melanoma. 34 However, excessive sun exposure was not noted for the 3 patients with DS with cutaneous melanoma reported in the literature. 35 It may be

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Katrina S. Pedersen, Kanwal Raghav and Michael J. Overman

to endometrial, ovarian, gastric, biliary, upper urinary tract, and skin cancers. The lifetime risk of developing SBA in Lynch-affected individuals remains low at about 1%, according to European registry studies, 26 , 27 and therefore no small bowel

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Paul F. Engstrom, Juan Pablo Arnoletti, Al B. Benson III, Jordan D. Berlin, J. Michael Berry, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Raza A. Dilawari, Dayna S. Early, Peter C. Enzinger, Marwan G. Fakih, James Fleshman Jr., Charles Fuchs, Jean L. Grem, James A. Knol, Lucille A. Leong, Edward Lin, Mary F. Mulcahy, Eric Rohren, David P. Ryan, Leonard Saltz, David Shibata, John M. Skibber, William Small Jr., Constantinos Sofocleous, James Thomas, Alan P. Venook and Christopher Willett

.NCCN.org [ST-2]) is the same one used to stage skin cancer because the cancers have a similar biology. 14 Lymph node staging is based on location of involved nodes in the staging of anal canal cancer: N1 designates metastasis in 1 or more perirectal nodes; N2

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NCCN Guidelines Insights: Uveal Melanoma, Version 1.2019

Featured Updates to the NCCN Guidelines

P. Kumar Rao, Christopher Barker, Daniel G. Coit, Richard W. Joseph, Miguel Materin, Ramesh Rengan, Jeffrey Sosman, John A. Thompson, Mark R. Albertini, Genevieve Boland, William E. Carson III, Carlo Contreras, Gregory A. Daniels, Dominick DiMaio, Alison Durham, Ryan C. Fields, Martin D. Fleming, Anjela Galan, Brian Gastman, Kenneth Grossman, Valerie Guild, Douglas Johnson, Giorgos Karakousis, Julie R. Lange, ScM, Kim Margolin, Sameer Nath, Anthony J. Olszanski, Patrick A. Ott, Merrick I. Ross, April K. Salama, Joseph Skitzki, Susan M. Swetter, Evan Wuthrick, Nicole R. McMillian and Anita Engh

excluded, as were those with metastases from melanoma or another cancer (except nonmelanoma skin cancers). 40 Only 16% of patients had tumors <2.0 mm from the optic disc. 39 Most of the tumors included were dome-shaped on B-scan ultrasound (77%), and

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Paul F. Engstrom, Mara G. Bloom, George Daniel Demetri, Phillip G. Febbo, William Goeckeler, Marc Ladanyi, Bryan Loy, Kate Murphy, Michael Nerenberg, Paul Papagni, Mark Robson, Robert W. Sweetman, Sean Tunis, Jessica DeMartino and Jonathan K. Larsen

-stage skin cancer . US Food and Drug Administration Web site. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm268241.htm . Accessed August 24, 2011 . 11 FDA approves Xalkori with companion diagnostic for a type of late

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Neha Mehta-Shah, Steven M. Horwitz, Stephen Ansell, Weiyun Z. Ai, Jeffrey Barnes, Stefan K. Barta, Mark W. Clemens, Ahmet Dogan, Kristopher Fisher, Aaron M. Goodman, Gaurav Goyal, Joan Guitart, Ahmad Halwani, Bradley M. Haverkos, Richard T. Hoppe, Eric Jacobsen, Deepa Jagadeesh, Matthew A. Lunning, Amitkumar Mehta, Elise A. Olsen, Barbara Pro, Saurabh A. Rajguru, Satish Shanbhag, Aaron Shaver, Andrei Shustov, Lubomir Sokol, Pallawi Torka, Carlos Torres-Cabala, Ryan Wilcox, Basem M. William, Jasmine Zain, Mary A. Dwyer, Hema Sundar and Youn H. Kim

involving inadequate response to skin-directed therapy or higher skin disease burden. Narrowband UVB carries a lower risk of secondary skin cancers and is preferred over PUVA in patients with early patch-stage or thin-plaque disease. Increasingly, very low

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Mary B. Daly, Tuya Pal, Michael P. Berry, Saundra S. Buys, Patricia Dickson, Susan M. Domchek, Ahmed Elkhanany, Susan Friedman, Michael Goggins, Mollie L. Hutton, CGC, Beth Y. Karlan, Seema Khan, Catherine Klein, Wendy Kohlmann, CGC, Allison W. Kurian, Christine Laronga, Jennifer K. Litton, Julie S. Mak, LCGC, Carolyn S. Menendez, Sofia D. Merajver, Barbara S. Norquist, Kenneth Offit, Holly J. Pederson, Gwen Reiser, CGC, Leigha Senter-Jamieson, CGC, Kristen Mahoney Shannon, Rebecca Shatsky, Kala Visvanathan, Jeffrey N. Weitzel, Myra J. Wick, Kari B. Wisinski, Matthew B. Yurgelun, Susan D. Darlow and Mary A. Dwyer

specific screening guidelines for melanoma, though more information can be found at the website for the National Council on Skin Cancer Prevention ( www.skincancer.org ). Information on pancreas screening can be found in PANC-A in these guidelines online at

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. Epidemiology/Risks AB2017-58. Incidence of Nonmelanoma Skin Cancer in the Medicare Advantage Population Laura E. Happe, PharmD, MPH a ; Howard Rogers, MD b ; Jonas Puente, MSc a ; Bryan Loy, MD a ; and Mara Beveridge, MD c From a Humana Inc., b Advanced

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Daniel G. Coit, John A. Thompson, Alain Algazi, Robert Andtbacka, Christopher K. Bichakjian, William E. Carson III, Gregory A. Daniels, Dominick DiMaio, Marc Ernstoff, Ryan C. Fields, Martin D. Fleming, Rene Gonzalez, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr, Richard W. Joseph, Julie R. Lange, Mary C. Martini, Miguel A. Materin, Anthony J. Olszanski, Merrick I. Ross, April K. Salama, Joseph Skitzki, Jeff Sosman, Susan M. Swetter, Kenneth K. Tanabe, Javier F. Torres-Roca, Vijay Trisal, Marshall M. Urist, Nicole McMillian and Anita Engh

infusion with cytotoxic drugs . J Skin Cancer 2011 ; 2011 : 106573 . 164. Thompson JF Kam PC Waugh RC Harman CR . Isolated limb infusion with cytotoxic agents: a simple alternative to isolated limb perfusion . Semin Surg Oncol 1998 ; 14

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Mary B. Daly, Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, Salil Goorha, Stephen B. Gruber, Heather Hampel, Virginia Kaklamani, Wendy Kohlmann, Allison Kurian, Jennifer Litton, P. Kelly Marcom, Robert Nussbaum, Kenneth Offit, Tuya Pal, Boris Pasche, Robert Pilarski, Gwen Reiser, Kristen Mahoney Shannon, Jeffrey R. Smith, Elizabeth Swisher and Jeffrey N. Weitzel

bilateral and multifocal cancer in paired organs. 98 Although not well defined, women with Cowden syndrome may have a 5% to 10% risk for developing endometrial cancer, 11 , 99 and an increased risk for uterine fibroids. In addition, skin cancers, renal