evident on MRI scans. The presenting signs and symptoms of metastatic brain lesions are similar to those of other mass lesions in the brain, such as headache, seizures, and neurologic impairment. Historically, whole-brain radiation therapy (WBRT) and
Louis Burt Nabors, Jana Portnow, Mario Ammirati, Henry Brem, Paul Brown, Nicholas Butowski, Marc C. Chamberlain, Lisa M. DeAngelis, Robert A. Fenstermaker, Allan Friedman, Mark R. Gilbert, Jona Hattangadi-Gluth, Deneen Hesser, Matthias Holdhoff, Larry Junck, Ronald Lawson, Jay S. Loeffler, Paul L. Moots, Maciej M. Mrugala, Herbert B. Newton, Jeffrey J. Raizer, Lawrence Recht, Nicole Shonka, Dennis C. Shrieve, Allen K. Sills Jr, Lode J. Swinnen, David Tran, Nam Tran, Frank D. Vrionis, Patrick Yung Wen, Nicole R. McMillian and Maria Ho
Joachim Yahalom
. Radiation therapy in the treatment of Hodgkin's disease: do you see what I see? J Natl Cancer Inst 2003 ; 95 : 928 – 929 . 3. Longo DL . Hodgkin disease: the sword of Damocles resheathed . Blood 2003 ; 104 : 3418 . 4. Longo DL
James L. Mohler
. ADT Plus Radiation Therapy Does radiation therapy (RT) make ADT more effective, and does ADT improve RT? In the phase III EORTC 22991 trial involving 819 patients, 3 the addition of short-term ADT to RT improved biochemical and clinical disease
NCCN Guidelines Insights: Soft Tissue Sarcoma, Version 1.2021
Featured Updates to the NCCN Guidelines
Margaret von Mehren, John M. Kane III, Marilyn M. Bui, Edwin Choy, Mary Connelly, Sarah Dry, Kristen N. Ganjoo, Suzanne George, Ricardo J. Gonzalez, Martin J. Heslin, Jade Homsi, Vicki Keedy, Ciara M. Kelly, Edward Kim, David Liebner, Martin McCarter, Sean V. McGarry, Christian Meyer, Alberto S. Pappo, Amanda M. Parkes, I. Benjamin Paz, Ivy A. Petersen, Matthew Poppe, Richard F. Riedel, Brian Rubin, Scott Schuetze, Jacob Shabason, Jason K. Sicklick, Matthew B. Spraker, Melissa Zimel, Mary Anne Bergman and Giby V. George
significant symptoms, intervention is recommended. Treatment options include surgery (if resectable), systemic therapy, definitive radiation therapy (RT), ablation procedures, or surgery with RT. Choice of therapy is dependent upon the anatomic location (ie
Gary L. Gallia, Steven Brem and Henry Brem
Schoenfeld D . Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study
Craig Brown, Sharon Ben-Or, Paul Walker and Mark Bowling
the main foci of therapy is stereotactic body radiation therapy (SBRT), which uses fiducial markers to track the movement of the lung during the respiratory cycle, minimizing the damage to normal tissue as high doses of radiation are applied to the
William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead and Rashmi Kumar
local disease with surgery, radiation therapy, or both, and systemic treatment with chemotherapy, endocrine therapy, biologic therapy, or combinations of these. The need for and selection of various local or systemic therapies are based on several
Carol D. Morris
conditions frequently treated with radiation therapy (RT). Within the pelvis, the ilium is the most common location for osteosarcoma, followed by the acetabulum then the ischium. Tumors frequently involve more than one part of the pelvis, and iliac tumors
Margaret A. Tempero, Mokenge P. Malafa, Mahmoud Al-Hawary, Horacio Asbun, Andrew Bain, Stephen W. Behrman, Al B. Benson III, Ellen Binder, Dana B. Cardin, Charles Cha, E. Gabriela Chiorean, Vincent Chung, Brian Czito, Mary Dillhoff, Efrat Dotan, Cristina R. Ferrone, Jeffrey Hardacre, William G. Hawkins, Joseph Herman, Andrew H. Ko, Srinadh Komanduri, Albert Koong, Noelle LoConte, Andrew M. Lowy, Cassadie Moravek, Eric K. Nakakura, Eileen M. O'Reilly, Jorge Obando, Sushanth Reddy, Courtney Scaife, Sarah Thayer, Colin D. Weekes, Robert A. Wolff, Brian M. Wolpin, Jennifer Burns and Susan Darlow
phase III CONKO-001 trial, in which 368 patients without prior chemotherapy or radiation therapy (RT) were randomly assigned to adjuvant gemcitabine versus observation following macroscopically complete resection, an intent-to-treat analysis of the data
Justin M. M. Cates
statistically significant in univariate sarcoma-specific survival analysis, with profound effects seen for histologic grade and distant metastasis, as expected ( supplemental eTable 3 ). Because HRs for radiation therapy before, during, or after surgical
