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Louis Burt Nabors, Jana Portnow, Mario Ammirati, Henry Brem, Paul Brown, Nicholas Butowski, Marc C. Chamberlain, Lisa M. DeAngelis, Robert A. Fenstermaker, Allan Friedman, Mark R. Gilbert, Jona Hattangadi-Gluth, Deneen Hesser, Matthias Holdhoff, Larry Junck, Ronald Lawson, Jay S. Loeffler, Paul L. Moots, Maciej M. Mrugala, Herbert B. Newton, Jeffrey J. Raizer, Lawrence Recht, Nicole Shonka, Dennis C. Shrieve, Allen K. Sills Jr, Lode J. Swinnen, David Tran, Nam Tran, Frank D. Vrionis, Patrick Yung Wen, Nicole R. McMillian and Maria Ho

evident on MRI scans. The presenting signs and symptoms of metastatic brain lesions are similar to those of other mass lesions in the brain, such as headache, seizures, and neurologic impairment. Historically, whole-brain radiation therapy (WBRT) and

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Joachim Yahalom

. Radiation therapy in the treatment of Hodgkin's disease: do you see what I see? J Natl Cancer Inst 2003 ; 95 : 928 – 929 . 3. Longo DL . Hodgkin disease: the sword of Damocles resheathed . Blood 2003 ; 104 : 3418 . 4. Longo DL

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James L. Mohler

. ADT Plus Radiation Therapy Does radiation therapy (RT) make ADT more effective, and does ADT improve RT? In the phase III EORTC 22991 trial involving 819 patients, 3 the addition of short-term ADT to RT improved biochemical and clinical disease

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NCCN Guidelines Insights: Soft Tissue Sarcoma, Version 1.2021

Featured Updates to the NCCN Guidelines

Margaret von Mehren, John M. Kane III, Marilyn M. Bui, Edwin Choy, Mary Connelly, Sarah Dry, Kristen N. Ganjoo, Suzanne George, Ricardo J. Gonzalez, Martin J. Heslin, Jade Homsi, Vicki Keedy, Ciara M. Kelly, Edward Kim, David Liebner, Martin McCarter, Sean V. McGarry, Christian Meyer, Alberto S. Pappo, Amanda M. Parkes, I. Benjamin Paz, Ivy A. Petersen, Matthew Poppe, Richard F. Riedel, Brian Rubin, Scott Schuetze, Jacob Shabason, Jason K. Sicklick, Matthew B. Spraker, Melissa Zimel, Mary Anne Bergman and Giby V. George

significant symptoms, intervention is recommended. Treatment options include surgery (if resectable), systemic therapy, definitive radiation therapy (RT), ablation procedures, or surgery with RT. Choice of therapy is dependent upon the anatomic location (ie

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Gary L. Gallia, Steven Brem and Henry Brem

Schoenfeld D . Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study

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Craig Brown, Sharon Ben-Or, Paul Walker and Mark Bowling

the main foci of therapy is stereotactic body radiation therapy (SBRT), which uses fiducial markers to track the movement of the lung during the respiratory cycle, minimizing the damage to normal tissue as high doses of radiation are applied to the

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead and Rashmi Kumar

local disease with surgery, radiation therapy, or both, and systemic treatment with chemotherapy, endocrine therapy, biologic therapy, or combinations of these. The need for and selection of various local or systemic therapies are based on several

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Carol D. Morris

conditions frequently treated with radiation therapy (RT). Within the pelvis, the ilium is the most common location for osteosarcoma, followed by the acetabulum then the ischium. Tumors frequently involve more than one part of the pelvis, and iliac tumors

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Margaret A. Tempero, Mokenge P. Malafa, Mahmoud Al-Hawary, Horacio Asbun, Andrew Bain, Stephen W. Behrman, Al B. Benson III, Ellen Binder, Dana B. Cardin, Charles Cha, E. Gabriela Chiorean, Vincent Chung, Brian Czito, Mary Dillhoff, Efrat Dotan, Cristina R. Ferrone, Jeffrey Hardacre, William G. Hawkins, Joseph Herman, Andrew H. Ko, Srinadh Komanduri, Albert Koong, Noelle LoConte, Andrew M. Lowy, Cassadie Moravek, Eric K. Nakakura, Eileen M. O'Reilly, Jorge Obando, Sushanth Reddy, Courtney Scaife, Sarah Thayer, Colin D. Weekes, Robert A. Wolff, Brian M. Wolpin, Jennifer Burns and Susan Darlow

phase III CONKO-001 trial, in which 368 patients without prior chemotherapy or radiation therapy (RT) were randomly assigned to adjuvant gemcitabine versus observation following macroscopically complete resection, an intent-to-treat analysis of the data

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Justin M. M. Cates

statistically significant in univariate sarcoma-specific survival analysis, with profound effects seen for histologic grade and distant metastasis, as expected ( supplemental eTable 3 ). Because HRs for radiation therapy before, during, or after surgical