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Van K. Morris and Cathy Eng

progressed on prior chemotherapy. Biomarkers for Response to Anti–PD-1 Therapies Favorable responses to immune checkpoint blockade agents in other advanced solid tumors such as melanoma, non–small cell lung cancer, and microsatellite instability

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Al B. Benson III, Alan P. Venook, Lynette Cederquist, Emily Chan, Yi-Jen Chen, Harry S. Cooper, Dustin Deming, Paul F. Engstrom, Peter C. Enzinger, Alessandro Fichera, Jean L. Grem, Axel Grothey, Howard S. Hochster, Sarah Hoffe, Steven Hunt, Ahmed Kamel, Natalie Kirilcuk, Smitha Krishnamurthi, Wells A. Messersmith, Mary F. Mulcahy, James D. Murphy, Steven Nurkin, Leonard Saltz, Sunil Sharma, David Shibata, John M. Skibber, Constantinos T. Sofocleous, Elena M. Stoffel, Eden Stotsky-Himelfarb, Christopher G. Willett, Christina S. Wu, Kristina M. Gregory and Deborah Freedman-Cass

marker. 146 , 156 , 157 , 169 – 174 A prospective analysis of tissues from patients with stage II and III colon cancer enrolled in the PETACC-3 trial showed that the BRAF mutation is prognostic for OS in patients with microsatellite instability

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Talia Golan and Milind Javle

mutations in the nucleotide excision repair system. The second observation in the 1990s was Lynch syndrome, a hereditary nonpolyposis colorectal cancer resulting from microsatellite instability (MSI), resulting from DNA mismatch repair impairment (MMR). 9

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Kohei Shitara and Atsushi Ohtsu

analysis, (5) microRNA analysis, and (6) reverse phase protein array. 12 Additionally, whole genome analysis and analysis of microsatellite instability (MSI) has been performed. 12 Four subtypes of gastric cancers have been described: (1) tumors positive

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Rondi M. Kauffmann, Leanne Goldstein, Emily Marcinkowski, George Somlo, Yuan Yuan, Philip H.G. Ituarte, Laura Kruper, Leslie Taylor and Courtney Vito

: 158 – 174 . 29. Baine M Sahak F Lin C . Marital status and survival in pancreatic cancer patients: a SEER based analysis . PloS One 2011 ; 6 : E21052 . 30. Ribie C Sargent D Moore M . Tumor microsatellite-instability status

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Viola Walter, Daniel Boakye, Janick Weberpals, Lina Jansen, Walter E. Haefeli, Uwe M. Martens, Phillip Knebel, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner

for potential confounders, we cannot exclude the possibility of residual confounding by factors potentially associated with chemotherapy administration but not adjusted for, such as functional status, microsatellite instability, enrollment in clinical

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Zhong Ye, Chun Wang, Limin Guo, Juan P. Palazzo, Zhixing Han, Yinzhi Lai, Jing Jiang, James A. Posey, Atrayee Basu Mallick, Bingshan Li, Li Jiang and Hushan Yang

microsatellite instability status, is missing as well. Therefore, it remains to be determined whether the model performance can be further improved by including additional clinical and laboratory variables with more complete data collection. Last, although

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Jeremy D. Kratz, Nataliya V. Uboha, Sam J. Lubner, Daniel L. Mulkerin, Linda Clipson, Yanyao Yi, Menggang Yu, Kristina A. Matkowskyj, Noelle K. LoConte and Dustin A. Deming

adenocarcinoma, KRAS wild-type status, and prior progression on chemotherapy containing 5-fluorouracil (5-FU), with cross-sectional imaging performed within 6 weeks of initiating therapy. A single patient with microsatellite instability was included in the

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John P. Sherbeck, Lili Zhao and Richard W. Lieberman

features associated with lymph node count . Dis Colon Rectum 2013 ; 56 : 1028 – 1035 . 11. Berg M Guriby M Nordgard O . Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers

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Ronan J. Kelly

carcinoma ( Figure 1 ). Additional aberrations that have been described include multiple losses of genetic material and microsatellite instability in different chromosomes (3p22-24.3; 3p14.2 [ FHIT gene locus]; 5q21 [ APC gene]; 6p21; 6p21-22.1; 7p21-22; 8