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Katy K. Tsai, Neharika Khurana, Timothy McCalmont, Adil Daud, Boris Bastian and Iwei Yeh

shown in the evolution of systemic treatment of unresectable BCC from cytotoxic chemotherapy to a molecularly targeted approach. Chemotherapy has shown some activity in case reports and small series, but advances in understanding BCC genetics and the

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Michael J. Hassett, Wei Jiang, Melissa E. Hughes, Stephen Edge, Sara H. Javid, Joyce C. Niland, Richard Theriault, Yu-Ning Wong, Deborah Schrag and Rinaa S. Punglia

collected at the initial DCIS diagnosis included sociodemographic characteristics, menopausal status, cancer stage, tumor pathology, and local treatments. Information gathered from subsequent chart reviews included systemic treatments and recurrence

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Enrique Soto-Perez-de-Celis, Pedro N. Aguiar Jr, Mónica L. Cordón, Yanin Chavarri-Guerra and Gilberto de Lima Lopes Jr

while maintaining quality of life (QoL). 5 Until 2008, no systemic treatments were available for the treatment of advanced HCC. However, improved understanding of its molecular drivers led to the development of randomized clinical trials (RCTs) of

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Kuan-Ling Kuo, David Stenehjem, Frederick Albright, Saurabh Ray and Diana Brixner

therapy (9.5 months), systemic therapy (7.1 months), and no therapy (2.9 months) ( Figure 4 and Table 4 ). Patients who only received radiation (median overall survival, 9.5 months; P =.159) or systemic treatment (median overall survival, 7.1 months; P

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Saranya Chumsri, Ethan S. Sokol, Aixa E. Soyano-Muller, Ricardo D. Parrondo, Gina A. Reynolds, Aziza Nassar and E. Aubrey Thompson

*), SPEN (E376*), SPTA1 (Q2195*), and TP53 (R248Q) and ZNF703 amplification, but no evidence of mismatch repair deficiency (dMMR). At that time, her systemic treatment was switched to fulvestrant and palbociclib. Figure 1. Chest wall mass consistent

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Xiang Gao, Amanda R. Kahl, Paolo Goffredo, Albert Y. Lin, Praveen Vikas, Imran Hassan and Mary E. Charlton

, each of these studies has been limited by selection bias because patient and/or disease factors, such as subsequent systemic treatment, tumor genetics, and metastatic burden, were not available. 9 – 13 As a result, current NCCN Guidelines for Colon

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Heidi Ko, Yaser Baghdadi, Charito Love and Joseph A. Sparano

prognosis and management. Therefore, accurate staging of breast cancer is critical in prognostication and guiding local and systemic treatments and their optimal sequencing. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast

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Presenter : Eunice S. Wang

enasidenib. This potentially lethal adverse event can develop at any time during the first 3 months of treatment, with symptoms that can mimic those of fungal or bacterial pneumonia. Systemic treatment with corticosteroids is recommended, and hydroxyurea is

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Steven S. Brem, Philip J. Bierman, Henry Brem, Nicholas Butowski, Marc C. Chamberlain, Ennio A. Chiocca, Lisa M. DeAngelis, Robert A. Fenstermaker, Allan Friedman, Mark R. Gilbert, Deneen Hesser, Larry Junck, Gerald P. Linette, Jay S. Loeffler, Moshe H. Maor, Madison Michael, Paul L. Moots, Tara Morrison, Maciej Mrugala, Louis Burt Nabors, Herbert B. Newton, Jana Portnow, Jeffrey J. Raizer, Lawrence Recht, Dennis C. Shrieve, Allen K. Sills Jr, Frank D. Vrionis and Patrick Y. Wen

effect and brain edema. Later scans are used to identify tumor recurrence. Early detection of recurrence is warranted, because local and systemic treatment options are available for patients with recurrent disease. However, MR spectroscopy, MR perfusion

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Jilma Patrick and Seema Ahsan Khan

following axillary dissection. 41 In the metastatic setting, this may only add to a patient’s suffering in the last few months or years of life. Complications from surgery may delay systemic treatment, which is the primary therapeutic modality in patients