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Maxim Norkin and John R. Wingard

Because of prolonged neutropenia and severe immunosuppression, patients with hematologic malignancies (HMs) and hematopoietic stem cell transplant (HSCT) recipients are at high risk for invasive fungal infections (IFIs), which are associated with

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Andrew D. Zelenetz and Pamela S. Becker

indications as filgrastim: to treat patients with nonmyeloid malignancies receiving myelosuppressive chemotherapy associated with a clinically significant incidence of febrile neutropenia (FN); patients with acute myeloid leukemia receiving induction or

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Dwight H. Owen, Lai Wei, Ashima Goyal, Ye Zhou, Sheryl-Ann Suffren, Rajani Jacob, Carly Pilcher, Gregory A. Otterson, Claire F. Verschraegen, Manisha H. Shah and Bhavana Konda

-free survival and overall survival data are not mature. Serious adverse events occurred in 4 patients - one patient had grade 3 bronchopulmonary hemorrhage, 3 patients had grade 4 neutropenia and/or thrombocytopenia. There were no treatment-related deaths

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Ju Wang, Ye Zhang, Long Yuan, Lin Ren, Yi Zhang and Xiaowei Qi

any grade (OR=0.37, 95% CrI=0.02-6.81). In addition, Olaparib also showed a low risk of neutropenia for adverse events of 3-4 grade (OR=0.57, 95% CrI=0.06-5.75) compared with Talazoparib. Both Talazoparib and Olaparib were not associated with high risk

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Ramon Mohanlal and Lan Huang

-106 (NCT03294577) with the small molecule immune modulator Plinabulin (Plin) for the prevention of chemotherapy-induced neutropenia (CIN), we unexpectedly observed an increase in plasma Hp levels with Plin. The positive CIN data this trial was reported

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Bradford R. Hirsch and Gary H. Lyman

recombinant human G-CSF made by a subsidiary of Teva Pharmaceuticals that has been approved by the FDA, because the agent has been shown to reduce the duration of severe neutropenia in patients with nonmyeloid malignancies undergoing cancer chemotherapy

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Michael Kleinberg

– 452 . 15 Pizzo PA Hathorn JW Hiemenz J . A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia . N Engl J Med 1986 ; 315 : 552 – 558 . 16 Winston DJ

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Apostolia M. Tsimberidou, Alexandra M. Adamopoulos, Yang Ye, Sarina Piha-Paul, Filip Janku, Siqing Fu, David Hong, Gerald S. Falchook, Aung Naing, Jennifer Wheler, Adoneca Fortier, Razelle Kurzrock and Kenneth R. Hess

regimens; (4) any other grade 3 nonhematologic toxicity, including symptoms/signs of vascular leak or cytokine release syndrome but excluding alopecia; (5) grade 4 thrombocytopenia; (6) any grade 4 neutropenia lasting more than 7 days (as defined by the NCI

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Peter L. Greenberg, Leon E. Cosler, Salvatore A. Ferro and Gary H. Lyman

descriptive review . Nat Clin Pract Oncol 2007 ; 4 : 643 – 656 . 29. Kuderer NM Dale DC Crawford J . Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients . Cancer 2006 ; 106 : 2258 – 2266 . 30

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Rachel M. Layman

. Neutropenia of all grades was observed in 88.5% of patients, 5 similar to the approximately 80% reported in PALOMA-2 and PALOMA-3. 2 , 3 Interestingly, there was less grade 3/4 neutropenia in this study (41.5% 5 vs 66.4% and 65% in PALOMA-2 2 and PALOMA-3