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Randall W. Burt, James S. Barthel, Kelli Bullard Dunn, Donald S. David, Ernesto Drelichman, James M. Ford, Francis M. Giardiello, Stephen B. Gruber, Amy L. Halverson, Stanley R. Hamilton, Mohammad K. Ismail, Kory Jasperson, Audrey J. Lazenby, Patrick M. Lynch, Edward W. Martin Jr., Robert J. Mayer, Reid M. Ness, Dawn Provenzale, M. Sambasiva Rao, Moshe Shike, Gideon Steinbach, Jonathan P. Terdiman and David Weinberg

should be based on the endoscopic and pathologic findings. Special attention should be given to polyps on the right side of the colon tract, because these tend to be associated with microsatellite instability (MSI) and hence greater cancer risk that

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Kristen Keon Ciombor and Tanios Bekaii-Saab

as cetuximab or panitumumab, 36 - 38 and the decision to forego adjuvant fluoropyrimidine monotherapy for patients with stage II CRC whose tumors have features of microsatellite instability. 39 - 41 As more genetic alterations in CRC are discovered

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Tarra Evans and Ursula Matulonis

identification of 4 classes of disease: polymerase ε (POLE) ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high consisting of mainly serous cancers. 21 Uterine serous carcinomas displayed genomic similarities with HGSOC

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David G. Hewett, Charles J. Kahi and Douglas K. Rex

cancer in those who develop the mutator phenotype (MSI-H) caused by inactivation of a DNA mismatch repair gene (methylation of MLH1 manifest as MSI-H). 53 , 55 Molecular analyses have shown proximal location, CIMP, and microsatellite instability to be

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Peter H. Carroll and James L. Mohler

Men with microsatellite instability (MSI) and mismatch repair deficiency (dMMR) should be referred for genetic counseling. These patients are eligible for pembrolizumab if their disease fails to respond to androgen deprivation therapy (ADT). The

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Jarushka Naidoo

debatable in the new era of chemotherapy plus immunotherapy in lung cancer,” she noted. According to the guidelines, microsatellite instability/mismatch repair deficiency (MSI/MMR) testing should be used in colon and endometrial cancers. And in renal cell

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Margaret A. Tempero

another approved treatment option for our patients.” Profiling of Mismatch Repair Deficiency Molecular profiling also detects mismatch repair deficiency (dMMR) and microsatellite instability–high (MSI-H) status. Across tumor types, patients with this

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David M. O’Malley

recurrent or refractory disease should include at least BRCA1/2 , microsatellite instability (MSI), or DNA mismatch repair, if not previously done. Testing for homologous repair deficiency can be considered. “Many will argue that MSI is rare in ovarian

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Charles M. Rudin, Christine L. Hann, Craig D. Peacock and D. Neil Watkins

lung cancer: concurrent analysis of chromosomal, mini- and microsatellite instability and loss of heterozygosity . Br J Cancer 2006 ; 94 : 1485 – 1491 . 16. Pandita A Aldape KD Zadeh G . Contrasting in vivo and in vitro fates of

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Samir Gupta, Dawn Provenzale, Scott E. Regenbogen, Heather Hampel, Thomas P. Slavin Jr, Michael J. Hall, Xavier Llor, Daniel C. Chung, Dennis J. Ahnen, Travis Bray, Gregory Cooper, Dayna S. Early, James M. Ford, Francis M. Giardiello, William Grady, Amy L. Halverson, Stanley R. Hamilton, Jason B. Klapman, David W. Larson, Audrey J. Lazenby, Patrick M. Lynch, Arnold J. Markowitz, Robert J. Mayer, Reid M. Ness, Niloy Jewel Samadder, Moshe Shike, Shajanpeter Sugandha, Jennifer M. Weiss, Mary A. Dwyer and Ndiya Ogba

; or, The patient is diagnosed with CRC with microsatellite instability (MSI) or loss of ≥1 DNA mismatch repair (MMR) proteins. In these 3 scenarios, syndrome-specific panels may be considered. Multigene testing may be considered in the