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Prajnan Das, Yixing Jiang, Jeffrey H. Lee, Manoop S. Bhutani, William A. Ross, Paul F. Mansfield and Jaffer A. Ajani

augmenting the effects of chemotherapy and radiation. The role of preoperative radiotherapy without concurrent chemotherapy was evaluated in a large randomized trial from China. 44 In this study, 370 patients with adenocarcinoma of the gastric cardia were

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William C. Huang and Bernard H. Bochner

. Postoperative nomogram predicting risk of recurrence following radical cystectomy for bladder cancer . J Clin Oncol 2006 ; 24 : 3967 – 3972 . 13. Galsky MD Bajorin DF . Chemotherapy for metastatic bladder, alone or in combination with other

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Andrew Wagner

. References 1. Gottlieb JA Baker LH Quagliana JM . Chemotherapy of sarcomas with a combination of adriamycin and dimethyl triazeno imidazole carboxamide . Cancer 1972 ; 30 ; 1632 – 1638 . 2. Santoro A Tursz T Mouridsen H . Doxorubicin

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Diane Reidy and Leonard Saltz

. 3. Punt CJ Koopman M Douma J . Sequential compared to combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (ACC): a Dutch Colorectal Cancer Group (DCCG) phase III study [abstract] . J Clin Oncol

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Anat Gafter-Gvili, David P. Steensma and Michael Auerbach

More than a decade has passed since Auerbach et al 1 presented the first study demonstrating synergy of intravenous (IV) iron with erythropoiesis-stimulating agents (ESAs) for correcting anemia in patients receiving chemotherapy for malignant

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Zachary Veitch, Omar F. Khan, Derek Tilley, Patricia A. Tang, Domen Ribnikar, Douglas A. Stewart, Xanthoula Kostaras, Karen King and Sasha Lupichuk

Background Treatment of early-stage breast cancer with adjuvant chemotherapy has improved survival. Landmark meta-analyses by the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) initially showed a 20% to 25% relative risk reduction in

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Joachim Yahalom

. Radiation therapy in Hodgkin disease: why risk a Pyrrhic victory? J Natl Cancer Inst 2005 ; 97 : 1394 – 1395 . 5. Canellos GP . Chemotherapy alone for early Hodgkin's lymphoma: an emerging option . J Clin Oncol 2005 ; 23 : 4574 – 4576

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Data adapted from Bergstrom et al. 1 Data based on reporting from 750 community oncology practices in the United States to McKesson Specialty Care Solutions. Adjuvant chemotherapy for breast cancer has evolved over several decades

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Matthew D. Galsky, Harry W. Herr and Dean F. Bajorin

value of the pathological response to combination chemotherapy before cystectomy in patients with invasive bladder cancer. European Organization for Research on Treatment of Cancer—Genitourinary Group . J Urol 1992 ; 147 : 606 – 608 . 11

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Jeffrey Crawford and George M. Rodgers

Chemotherapy-induced neutropenia is hazardous for 2 reasons: it produces febrile neutropenia (FN), which may result in life-threatening infections and prolonged hospitalizations, and it can necessitate chemotherapy dose reductions and delays