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Prajnan Das, Yixing Jiang, Jeffrey H. Lee, Manoop S. Bhutani, William A. Ross, Paul F. Mansfield and Jaffer A. Ajani

augmenting the effects of chemotherapy and radiation. The role of preoperative radiotherapy without concurrent chemotherapy was evaluated in a large randomized trial from China. 44 In this study, 370 patients with adenocarcinoma of the gastric cardia were

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William C. Huang and Bernard H. Bochner

. Postoperative nomogram predicting risk of recurrence following radical cystectomy for bladder cancer . J Clin Oncol 2006 ; 24 : 3967 – 3972 . 13. Galsky MD Bajorin DF . Chemotherapy for metastatic bladder, alone or in combination with other

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Jeffrey Allen and Mohammad Jahanzeb

Edited by Kerrin G. Robinson

-oat cell carcinoma of the lung with mediastinal lymph node metastases . Ann Surg 1983 ; 198 : 386 – 397 . 5. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical

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Andrew H. Ko and Christopher H. Crane

outcomes and overall survival, partly because of differences and limitations in study designs. Additional questions, such as the sequencing of radiation relative to chemotherapy and the optimal means of delivering radiation, remain and must be addressed

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Keli Turner, Sheelu Varghese and H. Richard Alexander

features typical of mesothelial cells, such as long, thin microvilli and the presence of a basal lamina. 29 Systemic Therapy Because of the rarity of this disease, a limited number of clinical trials are evaluating systemic chemotherapy specifically

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Andrew Wagner

. References 1. Gottlieb JA Baker LH Quagliana JM . Chemotherapy of sarcomas with a combination of adriamycin and dimethyl triazeno imidazole carboxamide . Cancer 1972 ; 30 ; 1632 – 1638 . 2. Santoro A Tursz T Mouridsen H . Doxorubicin

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Eric Roeland, Charles Loprinzi, Timothy J. Moynihan, Thomas J. Smith and Jennifer Temel

Chemotherapy remains the backbone of care for patients with metastatic cancer and provides increasing hope for patients and their families as novel drug targets and therapeutic agents are discovered. Over the past decade, the therapeutic arsenal

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William R. Kennedy, Christopher Tricarico, Prashant Gabani, Ashley A. Weiner, Michael B. Altman, Laura L. Ochoa, Maria A. Thomas, Julie A. Margenthaler, Souzan Sanati, Lindsay L. Peterson, Cynthia X. Ma, Foluso O. Ademuyiwa and Imran Zoberi

, management has changed little because TNBC is typically still treated as a single disease entity. With the increasing use of neoadjuvant chemotherapy (NAC), one factor that has emerged as an indicator of responsiveness to standard therapy has been the

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Diane Reidy and Leonard Saltz

. 3. Punt CJ Koopman M Douma J . Sequential compared to combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (ACC): a Dutch Colorectal Cancer Group (DCCG) phase III study [abstract] . J Clin Oncol

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Joachim Yahalom

. Radiation therapy in Hodgkin disease: why risk a Pyrrhic victory? J Natl Cancer Inst 2005 ; 97 : 1394 – 1395 . 5. Canellos GP . Chemotherapy alone for early Hodgkin's lymphoma: an emerging option . J Clin Oncol 2005 ; 23 : 4574 – 4576