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Jeffrey Allen and Mohammad Jahanzeb

Edited by Kerrin G. Robinson

-oat cell carcinoma of the lung with mediastinal lymph node metastases . Ann Surg 1983 ; 198 : 386 – 397 . 5. Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical

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Pooja Ghatalia and Elizabeth R. Plimack

urinary tract. Approximately 50% of patients with localized UC experience recurrence after cystectomy and approximately 4% present with metastatic UC (mUC) at diagnosis. 2 Cisplatin-based chemotherapy remains the standard first-line treatment for mUC, with

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Betsy L. Althaus

. Randomized, dose-escalation study of SD/01 compared with daily filgrastim in patients receiving chemotherapy . J Clin Oncol 2000 ; 18 : 2522 – 2528 . 7. Aapro MS Cameron DA Pettengell R . EORTC guidelines for the use of granulocyte

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Eric Roeland, Charles Loprinzi, Timothy J. Moynihan, Thomas J. Smith and Jennifer Temel

Chemotherapy remains the backbone of care for patients with metastatic cancer and provides increasing hope for patients and their families as novel drug targets and therapeutic agents are discovered. Over the past decade, the therapeutic arsenal

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William R. Kennedy, Christopher Tricarico, Prashant Gabani, Ashley A. Weiner, Michael B. Altman, Laura L. Ochoa, Maria A. Thomas, Julie A. Margenthaler, Souzan Sanati, Lindsay L. Peterson, Cynthia X. Ma, Foluso O. Ademuyiwa and Imran Zoberi

, management has changed little because TNBC is typically still treated as a single disease entity. With the increasing use of neoadjuvant chemotherapy (NAC), one factor that has emerged as an indicator of responsiveness to standard therapy has been the

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Scott M. Schuetze and Michael E. Ray

adjuvant chemotherapy . Ann Surg 1982 ; 196 : 305 – 315 . 7 Potter DA Kinsella T Glatstein E . High-grade soft tissue sarcomas of the extremities . Cancer 1986 ; 58 : 190 – 205 . 8 Pisters PW Harrison LB Leung DH . Long

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Keli Turner, Sheelu Varghese and H. Richard Alexander

features typical of mesothelial cells, such as long, thin microvilli and the presence of a basal lamina. 29 Systemic Therapy Because of the rarity of this disease, a limited number of clinical trials are evaluating systemic chemotherapy specifically

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John P. Stoutenburg and Harry Raftopoulos

comparing 5-HT3 receptor antagonists to conventional anti-emetics in the prophylaxis of acute chemotherapy-induced vomiting . Eur J Cancer 1997 ; 33 : 66 – 74 . 2 Grunberg SM Hansen M Deuson R : Incidence and impact of nausea/vomiting with

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Rosalyn A. Juergens and Arlene Forastiere

Edited by Kerrin G. Robinson

laparoscopy for staging esophageal cancer . Ann Thorac Surg 2007 ; 83 : 2000 – 2002 . 5. Medical Research Counsil Oesophageal Cancer Working Group . Surgical resection with or without preoperative chemotherapy in oesophageal cancer: a randomised

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Andrew H. Ko and Christopher H. Crane

outcomes and overall survival, partly because of differences and limitations in study designs. Additional questions, such as the sequencing of radiation relative to chemotherapy and the optimal means of delivering radiation, remain and must be addressed