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Margaret Tempero

. And the FDA has been very receptive to the concept of crosscutting approvals. Thank you! With the breakthrough of immuno-oncology, we now have pembrolizumab approved for any patient with a microsatellite instability (MSI)–high or mismatch repair (MMR

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Jorge Casas-Ganem and John H. Healey

Shooks J Fiedler PN . Microsatellite instability in sacral chordoma . J Surg Oncol 2000 ; 73 : 100 – 103 . 32 Riva P Crosti F Orzan F . Mapping of candidate region for chordoma development to 1p36.13 by LOH analysis . Int J Cancer 2003

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Margaret Tempero

response data alone. Pembrolizumab for microsatellite instability–high cancers and larotrectinib for cancers with NTRK gene fusions are cases in point. So, this past New Year’s Eve, I was happy for my patients with BRCA mutations because they now had

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characteristics, such as microsatellite instability-high (MSI-H), BRAF mutation, or HER2 overexpression. Hereditary risk assessment and screening are also essential components in caring for patients with intestinal cancers, since many are potentially preventable

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Dawn Provenzale, Samir Gupta, Dennis J. Ahnen, Travis Bray, Jamie A. Cannon, Gregory Cooper, Donald S. David, Dayna S. Early, Deborah Erwin, James M. Ford, Francis M. Giardiello, William Grady, Amy L. Halverson, Stanley R. Hamilton, Heather Hampel, Mohammad K. Ismail, Jason B. Klapman, David W. Larson, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, Reid M. Ness, Scott E. Regenbogen, Niloy Jewel Samadder, Moshe Shike, Gideon Steinbach, David Weinberg, Mary Dwyer and Susan Darlow

mutation in the family, personal history of CRC and more than 10 adenomas, personal history of CRC or endometrial cancer and additional risk factors, including: CRC diagnosis at younger than 50 years; High microsatellite instability (MSI) or abnormal

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James L. Mohler and Emmanuel S. Antonarakis

% HRD). 9 The 2019 version of the NCCN Guidelines recommends testing for HRD and for microsatellite instability (MSI) or MMR deficiencies in all patients with metastatic prostate cancer. An increased prevalence of these mutations might be found in

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Heterogeneity in Microsatellite Instability in Metastatic Colorectal Cancer: Mechanisms and Clinical Implications Yaeger Rona MD 10 2019 17 17 10 10 1263 1263 1264 1264 jnccn19239 10.6004/jnccn.2019.7348 Molecular Insights in Patient Care Targeting PD-L1 After

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Samir Gupta, Dawn Provenzale, Xavier Llor, Amy L. Halverson, William Grady, Daniel C. Chung, Sigurdis Haraldsdottir, Arnold J. Markowitz, Thomas P. Slavin Jr, Heather Hampel, CGC, Reid M. Ness, Jennifer M. Weiss, Dennis J. Ahnen, Lee-may Chen, Gregory Cooper, Dayna S. Early, Francis M. Giardiello, Michael J. Hall, Stanley R. Hamilton, Priyanka Kanth, Jason B. Klapman, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, June Mikkelson, CGC, Shajan Peter, Scott E. Regenbogen, Mary A. Dwyer, CGC and Ndiya Ogba

JP , . Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability . J Natl Cancer Inst 2004 ; 96 : 261 – 268 . 14970275 10.1093/jnci/djh034 32. Barnetson RA , Tenesa A

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Mary E. Charlton, Amanda R. Kahl, Alissa A. Greenbaum, Jordan J. Karlitz, Chi Lin, Charles F. Lynch and Vivien W. Chen

shown that right-sided cancer is associated with older age (≥75 years), female sex, larger tumor size, higher tumor grade, 14 and more frequent mucinous subtypes, 15 as well as microsatellite instability (MSI), 16 , 17 BRAF mutation, 18 , 19 EGFR

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Minhhuyen T. Nguyen and David S. Weinberg

that exfoliate into the mucocellular layer in the colonic lumen. 14 , 15 There are at least 3 distinct pathways to colon cancer, each with genetic and epigenetic components: the chromosomal instability pathway (CIN) and the microsatellite instability