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Lyndsay J. Willmott, Daniele A. Sumner and Bradley J. Monk

treatment protocol is surgical resection, typically with radical hysterectomy and pelvic lymph node dissection. Cure rates are good in this instance. However, more advanced disease is a greater challenge to treat effectively. The American Cancer Society

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Wui-Jin Koh, Benjamin E. Greer, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, Kathleen R. Cho, Christina Chu, David Cohn, Marta Ann Crispens, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Ernest Han, Warner K. Huh, John R. Lurain III, David Mutch, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Nelson Teng, Todd Tillmanns, Fidel A. Valea, Catheryn M. Yashar, Nicole R. McMillian and Jillian L. Scavone

cancer: should conization, simple trachelectomy, or simple hysterectomy replace radical surgery as the new standard of care? Gynecol Oncol 2014 ; 132 : 254 – 259 . 29. Cormier B Diaz JP Shih K . Establishing a sentinel lymph node mapping

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Thai H. Ho and Eric Jonasch

affected by cutaneous leiomyomas compared with the general population. 34 Because of symptomatic leiomyomas, women affected by HLRCC have higher rates of hysterectomy and undergo hysterectomy at a younger age, indicating a need for family planning

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Nadeem R. Abu-Rustum

preoperatively on office biopsy or dilatation and curettage will actually have higher-grade disease on final pathologic review after hysterectomy 11 ; therefore, it is of utmost importance to stage and treat these patients properly and avoid missing undetected

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Mary B. Daly, Robert Pilarski, Jennifer E. Axilbund, Michael Berry, Saundra S. Buys, Beth Crawford, Meagan Farmer, Susan Friedman, Judy E. Garber, Seema Khan, Catherine Klein, Wendy Kohlmann, Allison Kurian, Jennifer K. Litton, Lisa Madlensky, P. Kelly Marcom, Sofia D. Merajver, Kenneth Offit, Tuya Pal, Huma Rana, Gwen Reiser, Mark E. Robson, Kristen Mahoney Shannon, Elizabeth Swisher, Nicoleta C. Voian, Jeffrey N. Weitzel, Alison Whelan, Myra J. Wick, Georgia L. Wiesner, Mary Dwyer, Rashmi Kumar and Susan Darlow

ovarian preservation and onset of early menopause. 40 Salpingectomy has been shown to be a safe and feasible procedure when performed at the same time as hysterectomy. 36 , 41 Despite evidence regarding the safety and feasibility of salpingectomy, more

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NCCN Guidelines Insights: Cervical Cancer, Version 1.2020

Featured Updates to the NCCN Guidelines

Nadeem R. Abu-Rustum, Catheryn M. Yashar, Sarah Bean, Kristin Bradley, Susana M. Campos, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Christine M. Fisher, Peter Frederick, David K. Gaffney, Robert Giuntoli II, Ernest Han, Warner K. Huh, John R. Lurain III, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Rachel Sisodia, Todd Tillmanns, Stefanie Ueda, Renata Urban, Emily Wyse, Nicole R. McMillian and Angela D. Motter

retrospective studies on use of the Silva classification system. Spaans et al 23 classified tumor samples from 82 patients with stage IB–IIA usual-type EAC, all of whom previously underwent radical hysterectomy or trachelectomy. Median follow-up time was

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Brandon A. Dyer, Dmitriy Zamarin, Ramez N. Eskandar and Jyoti M. Mayadev

combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis . Int J Radiat Oncol Biol Phys 1979 ; 5 : 317 – 322 . 3. Keys HM Bundy BN Stehman FB . Cisplatin, radiation, and adjuvant hysterectomy compared with

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Annika M. Gustafson, Deborah J. Goldfrank, William A. Dunson, Daniel L. Mulkerin, Rebecca L. Caires and Keith D. Eaton

includes all female patients between the onset of menses and menopause (defined by the absence of menses for 12 consecutive months), excluding those who have had prior medical intervention leading to infertility, such as a hysterectomy. Because it is

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Robert W. Carlson, Jillian L. Scavone, Wui-Jin Koh, Joan S. McClure, Benjamin E. Greer, Rashmi Kumar, Nicole R. McMillian and Benjamin O. Anderson

Cancer J Clin 2011 ; 61 : 69 – 90 . 26. Kokka F Bryant A Brockbank E . Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer . Cochrane Database Syst Rev 2015 ; 4 : CD010260 . 27

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Anita Pudusseri and Alex C. Spyropoulos

are considered to be associated with a high risk of bleeding. Operations and procedures associated with a low risk of bleed include cholecystectomy, abdominal hysterectomies or hernia repairs, most laparoscopic procedures, noncoronary angiography, and