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Robert E. Glasgow, David H. Ilson, James A. Hayman, Hans Gerdes, Mary F. Mulcahy and Jaffer A. Ajani

significant recent advances in preoperative staging modalities to optimize patient selection for treatment. In addition, treatment algorithms consisting of a combination of chemotherapy, radiation therapy, and surgery have been developed to optimize treatment

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Li-Ting Liu, Qiu-Yan Chen, Lin-Quan Tang, Shan-Shan Guo, Ling Guo, Hao-Yuan Mo, Yang Li, Qing-Nan Tang, Xue-Song Sun, Yu-Jing Liang, Chong Zhao, Xiang Guo, Chao-Nan Qian, Mu-Sheng Zeng, Jin-Xin Bei, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma and Hai-Qiang Mai

with concurrent chemotherapy has been shown to be the standard treatment protocol. 4 , 5 Despite the use of concurrent chemotherapy, distant metastasis is still a major component of treatment failures, occurring in 18% to 27% of patients. 5 , 6 To

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Ali A. Mokdad, Rebecca M. Minter, Adam C. Yopp, Matthew R. Porembka, Sam C. Wang, Hong Zhu, Mathew M. Augustine, John C. Mansour, Michael A. Choti and Patricio M. Polanco

Approximately 10% to 20% of patients with pancreatic adenocarcinoma present with resectable disease, and treatment often constitutes resection followed by chemotherapy (CT). 1 – 5 More recently, however, preoperative therapy has been increasing

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Gary H. Lyman and Marek S. Poniewierski

Neutropenia and its complications represent the major dose-limiting toxicities associated with systemic cancer chemotherapy and is associated with considerable morbidity, mortality, and cost. 1 Neutropenic events may result in dose reductions or

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Laura Spring, Rachel Greenup, Andrzej Niemierko, Lidia Schapira, Stephanie Haddad, Rachel Jimenez, Suzanne Coopey, Alphonse Taghian, Kevin S. Hughes, Steven J. Isakoff, Leif W. Ellisen, Barbara L. Smith, Michelle Specht, Beverly Moy and Aditya Bardia

young women with breast cancer. Neoadjuvant chemotherapy (NAC) is being increasingly used in the management of localized breast cancer as an alternative to adjuvant chemotherapy. Studies have shown that the benefit of chemotherapy is similar when given

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Zi-Xian Wang, Hao-Xiang Wu, Ming-Ming He, Ying-Nan Wang, Hui-Yan Luo, Pei-Rong Ding, Dan Xie, Gong Chen, Yu-Hong Li, Feng Wang and Rui-Hua Xu

efficacy of chemotherapy + cetuximab (Cet) or panitumumab (Pani) versus chemotherapy ± bevacizumab (Bev) reported significant improvement in overall survival (OS), progression-free survival (PFS), and objective response rate (ORR) with chemotherapy + Cet

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Michaela A. Dinan, Lauren E. Wilson and Shelby D. Reed

Background The introduction of genomic tests such as the Oncotype DX 21-gene recurrence score (RS) assay has allowed the omission of adjuvant chemotherapy for patients with estrogen receptor (ER)–positive, node-negative breast cancer who have a low

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Christopher M. Booth, Sulaiman Nanji, Xuejiao Wei, Yingwei Peng, James J. Biagi, Timothy P. Hanna, Monika K. Krzyzanowska and William J. Mackillop

Background International treatment guidelines have recommended 5-fluorouracil (FU)–based adjuvant chemotherapy (ACT) for patients with stage III colon cancer since the 1990s. 1 This is based on a series of randomized controlled trials (RCTs

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Prashant Gabani, Emily Merfeld, Amar J. Srivastava, Ashley A. Weiner, Laura L. Ochoa, Dan Mullen, Maria A. Thomas, Julie A. Margenthaler, Amy E. Cyr, Lindsay L. Peterson, Michael J. Naughton, Cynthia Ma and Imran Zoberi

advanced TNBC typically receive chemotherapy, surgery, and radiation therapy (RT). More recently, the concept of neoadjuvant chemotherapy (NAC) followed by surgery and RT has been introduced in women with locally advanced or palpable TNBC, 6 because TNBC

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Betsy L. Althaus

. Randomized, dose-escalation study of SD/01 compared with daily filgrastim in patients receiving chemotherapy . J Clin Oncol 2000 ; 18 : 2522 – 2528 . 7. Aapro MS Cameron DA Pettengell R . EORTC guidelines for the use of granulocyte