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Mesa Ruben A. MD 5 2017 15 15 5S 5S 720 720 722 722 0150720 10.6004/jnccn.2017.0083 Active Systemic Treatment of Pancreatic Cancer Tempero Margaret MD 5 2017 15 15 5S 5S 723 723 725 725 0150723 10.6004/jnccn.2017.0084 Opportunities

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Lee S. Schwartzberg and Sarah L. Blair

with small hormone-sensitive tumors and who have been compliant with endocrine therapy for 5 years are able to have breast conservation without radiation and preserve overall survival. 9 Determining Systemic Treatment for Older Patients Systemic

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NCCN Guidelines Insights: Kidney Cancer, Version 2.2020

Featured Updates to the NCCN Guidelines

Robert J. Motzer, Eric Jonasch, M. Dror Michaelson, Lakshminarayanan Nandagopal, John L. Gore, Saby George, Ajjai Alva, Naomi Haas, Michael R. Harrison, Elizabeth R. Plimack, Jeffrey Sosman, Neeraj Agarwal, Sam Bhayani, Toni K. Choueiri, Brian A. Costello, Ithaar H. Derweesh, Thomas H. Gallagher, Steven L. Hancock, Christos Kyriakopoulos, Chad LaGrange, Elaine T. Lam, Clayton Lau, Bryan Lewis, Brandon Manley, Brittany McCreery, Andrew McDonald, Amir Mortazavi, Phillip M. Pierorazio, Lee Ponsky, Bruce G. Redman, Bradley Somer, Geoffrey Wile, Mary A. Dwyer, CGC, Lydia J. Hammond and Griselda Zuccarino-Catania

with stage IV disease who have any poor-risk features, clear cell histology, and high-volume distant metastases, instead of cytoreductive nephrectomy followed by systemic treatment (see KID-2 , page 1281). This recommendation is based on results of the

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Benjamin O. Anderson

histologic (rather than cytologic) samples that can distinguish invasive from noninvasive cancers and are more easily amendable to immunohistochemical staining (estrogen receptor, progesterone receptor, HER2/neu) to facilitate surgical and systemic treatment

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Claudia S.E.W. Schuurhuizen, Patricia Marino, Annemarie M.J. Braamse, Laurien M. Buffart, Florence Joly, Karim Fizazi, Muriel Habibian, Jean-Marie Boher, Michel Soulie, Stéphane Oudard, Inge R.H.M. Konings, Henk M.W. Verheul, Joost Dekker and Gwenaelle Gravis

(systemic) treatments may be limited, the number and extent of AEs and their impact on patient quality of life (QoL) are important. 2 Providing a representative overview of treatment-related AEs is essential for patients to make an informed decision to

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Financial Toxicity: More Crucial Than Ever in the Time of COVID-19 Knight Thomas G. MD 07 2020 18 18 7 7 915 915 916 916 jnccn20279 10.6004/jnccn.2020.7602 Molecular Insights in Patient Care Neoadjuvant Immunotherapy–Based Systemic Treatment in MMR

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Sri Harsha Tella, Anuhya Kommalapati, Apar Kishor Ganti and Alissa S. Marr

Disease Significant differences were identified in the management of stage IV cutaneous MMel by facility volume. Patients at T3 facilities were more likely to receive systemic treatment (69%, 74%, and 83% at T1, T2, and T3 facilities, respectively; P

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A. Scott Paulson and Emily K. Bergsland

also has proven antitumor activity in tumors arising in the small bowel. 10 Beyond octreotide, no standard therapy exists. Additional systemic treatment options are desperately needed. Recent data suggest that vascular endothelial growth factor (VEGF

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Elliott K. Yee, Natalie G. Coburn, Laura E. Davis, Alyson L. Mahar, Victoria Zuk, Vaibhav Gupta, Ying Liu, Craig C. Earle and Julie Hallet

. Quality Person-Centred Systemic Treatment in Ontario: 2014–2019 Systemic Treatment Provincial Plan. Cancer Care Ontario. Accessed November 6, 2020. Available at:

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David E. Misek, Tasneem H. Patwa, David M. Lubman and Diane M. Simeone

Shureiqi I . Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer . J Clin Oncol 2001 ; 19 : 4202 – 4208 . 11. Goldhirsch A Colleoni M Domenighetti G . Systemic