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Ann M. Berger, Amy Pickar Abernethy, Ashley Atkinson, Andrea M. Barsevick, William S. Breitbart, David Cella, Bernadine Cimprich, Charles Cleeland, Mario A. Eisenberger, Carmen P. Escalante, Paul B. Jacobsen, Phyllis Kaldor, Jennifer A. Ligibel, Barbara A. Murphy, Tracey O'Connor, William F. Pirl, Eve Rodler, Hope S. Rugo, Jay Thomas and Lynne I. Wagner

Overview Fatigue is a common symptom in patients with cancer and is nearly universal in those undergoing cytotoxic chemotherapy, radiation therapy, bone marrow transplantation, or treatment with biologic response modifiers. 1 – 10 The symptom

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Brandon A. Mahal, Ming-Hui Chen, Andrew A. Renshaw, Marian J. Loffredo, Philip W. Kantoff and Anthony V. D'Amico

Background Prostate cancer (PC) is the most common noncutaneous malignancy in men, with 161,360 new cases and 26,730 deaths due to PC in 2017. 1 Although radical prostatectomy (RP) or radiation therapy (RT) with or without androgen

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Michael J. Hassett, Wei Jiang, Melissa E. Hughes, Stephen Edge, Sara H. Javid, Joyce C. Niland, Richard Theriault, Yu-Ning Wong, Deborah Schrag and Rinaa S. Punglia

As the incidence of ductal carcinoma in situ (DCIS) has increased, so has the number of DCIS survivors. 1 Most patients with DCIS are treated with breast-conserving surgery (BCS). 2 Radiation therapy (RT) and antiestrogen therapy (AET) have been

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Traci LeMasters, S. Suresh Madhavan, Usha Sambamoorthi, Hannah W. Hazard-Jenkins, Kimberly M. Kelly and Dustin Long

health and functional status associated with older age. 6 , 8 , 9 The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer contain 2 age-based treatment concessions. The first is the omission of radiation therapy (RT

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Paul Cinciripini

treatment, fewer and less serious adverse events (AEs), increased energy, and better quality of life. A recent study found that smoking cessation after stereotactic body radiation therapy improved overall survival in patients with non–small cell lung cancer

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Vishwajith Sridharan, Vinayak Muralidhar, Danielle N. Margalit, Roy B. Tishler, James A. DeCaprio, Manisha Thakuria, Guilherme Rabinowits and Jonathan D. Schoenfeld

, sentinel lymph node biopsy (SLNB), and adjuvant local and regional radiation therapy (RT). 7 , 8 SLNB specifically has become more common during the last decade, potentially impacting staging and treatment. Chemotherapy and concurrent chemoradiation

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Renato G. Martins, Thomas A. D’Amico, Billy W. Loo Jr, Mary Pinder-Schenck, Hossein Borghaei, Jamie E. Chaft, Apar Kishor P. Ganti, Feng-Ming (Spring) Kong, Mark G. Kris, Inga T. Lennes and Douglas E. Wood

staging system, 2 the determination of operable stage IIIA (treated with induction therapy followed by surgery) versus inoperable stage IIIA (treated with definitive chemotherapy and radiation therapy) remains controversial. Moreover, some investigators

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Robert E. Glasgow, David H. Ilson, James A. Hayman, Hans Gerdes, Mary F. Mulcahy and Jaffer A. Ajani

significant recent advances in preoperative staging modalities to optimize patient selection for treatment. In addition, treatment algorithms consisting of a combination of chemotherapy, radiation therapy, and surgery have been developed to optimize treatment

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Prajnan Das, Yixing Jiang, Jeffrey H. Lee, Manoop S. Bhutani, William A. Ross, Paul F. Mansfield and Jaffer A. Ajani

chemoradiation therapy. Chemoradiation consisted of 1 cycle of 5-fluorouracil (5-FU) and leucovorin, followed by radiation therapy (45 Gy) with concurrent bolus 5-FU and leucovorin, followed by 2 more cycles of 5-FU and leucovorin. Patients in the chemoradiation

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Matthias Holdhoff

-DNA methyltransferase; PCV, procarbazine, lomustine, and vincristine; RT, radiation therapy. better understood as an astrocytoma,” Dr. Holdhoff explained. It is also associated with mutations in IDH, CIC , and FUBP1 . 14 Two randomized prospective trials 5