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Piet Dirix, Lynda Wyld, Shani Paluch-Shimon and Philip Poortmans

-based radiation therapy, patient inclusion could foreseeably be broadened further. For instance, a retrospective study of 16,233 patients with solid tumors receiving contemporary chemotherapy regimens found negligible differences in relative dose intensity between

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Joseph A. Roscoe, Gary R. Morrow, Jane T. Hickok, Karen M. Mustian and Abhay R. Shelke

This work was supported in part by Public Health Service grant U10 CA37420 and by grant RSG-01-071-PBP from the American Cancer Society. References 1 Lyman GH Dale DC Crawford J . Incidence and predictors of low dose-intensity

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Pilar de la Morena Barrio, María Ángeles Vicente Conesa, Enrique González-Billalabeitia, Edgar Urrego, Elisa García-Garre, Elena García-Martínez, Marta Zafra Poves, Vicente Vicente and Francisco Ayala de la Peña

age or other clinical characteristics, except for a trend toward worse performance status in the DM group ( P =.07). Dose level, median total dose, and dose intensity of wP were also well balanced between groups. Finally, neither administration of G

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Gregory P. Kalemkerian, Wallace Akerley, Paul Bogner, Hossein Borghaei, Laura QM Chow, Robert J. Downey, Leena Gandhi, Apar Kishor P. Ganti, Ramaswamy Govindan, John C. Grecula, James Hayman, Rebecca Suk Heist, Leora Horn, Thierry Jahan, Marianna Koczywas, Billy W. Loo Jr, Robert E. Merritt, Cesar A. Moran, Harvey B. Niell, Janis O’Malley, Jyoti D. Patel, Neal Ready, Charles M. Rudin, Charles C. Williams Jr, Kristina Gregory and Miranda Hughes

designed to increase dose intensity. Early phase II results of this approach were promising, although favorable patient selection was of some concern. 77 , 78 Nevertheless, no survival benefits were documented in randomized trials, and excessive treatment

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Jerome Kim and Arti Hurria

were associated with decreased chemotherapy dose-intensity, whereas depression and poor cognition predicted the need for hospitalization. A separate study in older women with advanced ovarian cancer found depression, lack of autonomy, and a performance

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Amy A. Kirkham, Karen A. Gelmon, Cheri L. Van Patten, Kelcey A. Bland, Holly Wollmann, Donald C. McKenzie, Taryne Landry and Kristin L. Campbell

chemotherapy (≥5 days later than planned); (2) relative dose intensity (RDI) 18 ; (3) receipt of <85% of RDI; (4) prevalence of reasons for dose reduction or delay; (5) risk and severity of neutropenia or anemia (defined by NCI’s CTCAE version 5.0) for ≥1

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Kenneth Anderson

): Abstract 2 . 6. Larocca A Cavallo F Magarotto V . Reduced dose-intensity subcutaneous bortezomib plus prednisone (VP) or plus cyclophosphamide (VCP) or plus melphalan (VMP) for newly diagnosed multiple myeloma patients older than 75 years of age

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Presenter : Steven M. Horwitz

-free survival and no benefit in overall survival (OS). More dose intensity involves consolidating patients with autoSCT. To evaluate the efficacy of a dose-dense approach consolidated by up-front high-dose chemotherapy and autoSCT in PTCL, the Nordic Lymphoma

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Ellin Berman

analysis of the phase II study found the following factors to be risk factors for arterial thrombotic events: older age ( P <.0001), history of diabetes ( P =.0003), higher dose intensity to Table 2 Incidence of Vascular Occlusive Events Over Time

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Eric T. Wong, Shiva Gautam, Christopher Malchow, Melody Lun, Edward Pan and Steven Brem

mg/kg every 4 weeks, and 15 mg/kg every 3 weeks, resulting in a respective dose intensity of 30 mg/kg, 60 mg/kg, 30 mg/kg, and 60 mg/kg, respectively, within a 12-week period. This heterogeneous dose intensity may result in slightly different rates of