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Sharon H. Giordano, Anthony D. Elias and William J. Gradishar

hormone receptor–positive/HER2-negative disease, with these indications: Palbociclib: in combination with an aromatase inhibitor (AI) as initial therapy in postmenopausal women, and in combination with fulvestrant in patients with metastatic disease who

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Jason Hu, Armen G. Aprikian, Marie Vanhuyse and Alice Dragomir

therapy, such as aromatase inhibitors or tamoxifen, should undergo baseline BMD tests given the effect of those drugs on BMD. 42 Given the contextual similarity between patients with breast cancer and those with PCa treated with hormonal therapy, it is

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6 months. 1 Subsequently in 1977, the FDA approved tamoxifen for treatment of breast cancer with a standard dose of 20 mg by mouth once daily. Aromatase inhibitors (AIs) have shown significant improvements in survival and remain part of a first

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Kostandinos Sideras and Charles L. Loprinzi

in women with increased risk by 48%, 8 and raloxifene has shown a similar efficacy with tamoxifen at reducing the risk of invasive breast cancer in the same increased risk population. 9 Given the strong efficacy aromatase inhibitors have shown in

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Michaela J. Higgins, James M. Rae, David A. Flockhart, Daniel F. Hayes and Vered Stearns

; 100 : 642 – 648 . 57 Hayes DF Stearns V Rae J . A model citizen? Is tamoxifen more effective than aromatase inhibitors if we pick the right patients? J Natl Cancer Inst 2008 ; 100 : 610 – 613 . 58 Early Breast Cancer

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Lee S. Schwartzberg and Sarah L. Blair

years. Interestingly, despite a high RS, older patients were far less likely to receive chemotherapy than younger patients. 11 Benefit of Endocrine Therapy The benefit of aromatase inhibitors over tamoxifen extends to both older and younger

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Michelle E. Melisko and Joseph B. Narus

-term use of hormonal agents such as tamoxifen and aromatase inhibitors can cause vasomotor and musculoskeletal symptoms. 3 For both men and women who have had surgery for rectal cancer, sexual problems afterward are “common, multifactorial, inadequately

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William J. Gradishar

patients with prior aromatase inhibitor (AI) therapy, “reflecting what we may do in practice when a patient progresses,” he added. The combination doubled the duration of PFS, from 4.6 to 9.6 months. 3 Together, the 3 pivotal trials with palbociclib

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Michael J. Hassett, Wei Jiang, Melissa E. Hughes, Stephen Edge, Sara H. Javid, Joyce C. Niland, Richard Theriault, Yu-Ning Wong, Deborah Schrag and Rinaa S. Punglia

diagnosis was defined as documentation of therapy with a selective ER modulator, aromatase inhibitor, or gonadotropin-releasing hormone agonist lasting at least 30 days after diagnosis and starting >30 days before any SBE. Descriptive statistics for the use

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Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Mohammad Jahanzeb, Krystyna Kiel, Britt-Marie Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lisle M. Nabell, Lori J. Pierce, Elizabeth C. Reed, Mary Lou Smith, George Somlo, Richard L. Theriault, Neal S. Topham, John H. Ward, Eric P. Winer and Antonio C. Wolff

in breast cancer (BC) [abstract] . Proc Am Soc Clin Oncol 2002 ; 21 : Abstract 164 . 161 Smith IE Dowsett M Yap YS . Adjuvant aromatase inhibitors for early breast cancer after chemotherapy-induced amenorrhoea: caution and suggested