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Mod C. Chandhanayingyong, Nicholas M. Bernthal, Piti Ungarreevittaya, Scott D. Nelson, Sant P. Chawla and Arun S. Singh

, and GCDFP-15. This specimen was sent for fluorescence in situ hybridization analysis and showed an EWSR1 gene rearrangement. Based on these results, the diagnosis of Ewing sarcoma was made. Figure 1 (A) An anteroposterior plain radiograph of

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Margaret von Mehren

-01. References 1 Jemal A Tiwari R Murray T . Cancer statistics, 2004 . CA Cancer J Clin 2004 ; 54 : 8 – 29 . 2 Elias A Ryan L Aisner J . Mesna, doxorubicin, ifosfamide, dacarbazine (MAID) regimen for adults with advanced sarcoma . Semin

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Timothy Lindsay and Sujana Movva

Soft tissue sarcoma (STS) is a diverse category of >50 distinct malignancies that pose many diagnostic and treatment-related challenges due to their remarkable heterogeneity. Molecular profiling has emerged as a useful tool for the mechanistic

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Andrew Wagner

. References 1. Gottlieb JA Baker LH Quagliana JM . Chemotherapy of sarcomas with a combination of adriamycin and dimethyl triazeno imidazole carboxamide . Cancer 1972 ; 30 ; 1632 – 1638 . 2. Santoro A Tursz T Mouridsen H . Doxorubicin

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Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance

Soft tissue sarcomas are the most frequent sarcomas; the annual incidence for 2007 in the United States is estimated at about 9220 cases, with an overall mortality rate of approximately 3560 cases per year. Important updates for the 2007 version of the guidelines include the addition of epirubicin (single agent) and the combination of epirubicin, ifosfamide, and mesna as generally accepted systemic therapy. Imatinib was added as an option for desmoid tumors.

For the most recent version of the guidelines, please visit NCCN.org

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Richard B. Hostetter, Min Yan, Houman Vaghefi, Kenneth Pennington and Gary Cornette

stabilization, the patient underwent a transanal resection of the mass the following day. An endoscopic gastrointestinal anastomosis stapler resulted in a margin-negative complete resection of what was later determined to be a high-grade synovial cell sarcoma

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Donald A. Podoloff, Douglas W. Ball, Edgar Ben-Josef, Al B. Benson III, Steven J. Cohen, R. Edward Coleman, Dominique Delbeke, Maria Ho, David H. Ilson, Gregory P. Kalemkerian, Richard J. Lee, Jay S. Loeffler, Homer A. Macapinlac, Robert J. Morgan Jr., Barry Alan Siegel, Seema Singhal, Douglas S. Tyler and Richard J. Wong

assessing the resectability of pancreatic cancer . J Nucl Med 2008 ; 49 : 1408 – 1413 . 8 Tateishi U Yamaguchi U Seki K . Bone and soft-tissue sarcoma: preoperative staging with fluorine 18 fluorodeoxyglucose PET/CT and conventional imaging

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NCCN Guidelines® Updates: AIDS-Related Kaposi Sarcoma The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for AIDS-Related Kaposi Sarcoma published in this issue (page 171) include the latest updates. To assist readers interested in

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J. Sybil Biermann, Douglas R. Adkins, Robert S. Benjamin, Brian Brigman, Warren Chow, Ernest U. Conrad III, Deborah A. Frassica, Frank J. Frassica, Suzanne George, Kenneth R. Hande, Francis J. Hornicek, G. Douglas Letson, Joel Mayerson, Sean V. McGarry, Brian McGrath, Carol D. Morris, Richard J. O'Donnell, R. Lor Randall, Victor M. Santana, Robert L. Satcher, Herrick J. Siegel, Neeta Somaiah and Alan W. Yasko

. Osteosarcoma (35%), chondrosarcoma (30%), and Ewing's sarcoma (16%) are the 3 most common forms of bone cancer. Malignant fibrous histiocytoma (MFH) and fibrosarcoma of the bone constitute fewer than 1% of all primary bone tumors. Chondrosarcoma is usually

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Stanley J. Miller, Murad Alam, James S. Andersen, Daniel Berg, Christopher K. Bichakjian, Glen M. Bowen, Richard T. Cheney, L. Frank Glass, Roy C. Grekin, Alan L. Ho, Anne Kessinger, Nanette Liegeois, Daniel D. Lydiatt, Jeff Michalski, William H. Morrison, Kishwer S. Nehal, Kelly C. Nelson, Paul Nghiem, Thomas Olencki, Clifford S. Perlis, Ashok R. Shaha, Malika Tuli, Marshall M. Urist, Linda C. Wang and John A. Zic

Guidelines] for Basal Cell and Squamous Cell Skin Cancers and Merkel Cell Carcinoma; to view the most recent version of these guidelines, visit the NCCN Web site at www.NCCN.org ). The NCCN Soft Tissue Sarcoma Panel provided expert input in the development