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Jerome Kim and Arti Hurria

RA, et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol 2002;20:494-502; with permission

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Apar Kishor Ganti, Mollie deShazo, Alva B. Weir III and Arti Hurria

burden in the elderly. 2 However, most evidence used in the treatment of older patients with NSCLC is extrapolated from data on younger patients because of the lack of good quality evidence specific to the older population. 3 , 4 Studies also suggest

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Viola Walter, Daniel Boakye, Janick Weberpals, Lina Jansen, Walter E. Haefeli, Uwe M. Martens, Phillip Knebel, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner

, LV, oxaliplatin). 9 , 10 5-FU/LV alone has been shown to prolong survival throughout age groups, 11 , 12 even in patients aged >75 years. 13 , 14 However, the benefit of oxaliplatin-based therapy in elderly patients is viewed more skeptically, 15

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Andrew D. Zelenetz, William G. Wierda, Jeremy S. Abramson, Ranjana H. Advani, C. Babis Andreadis, Nancy Bartlett, Naresh Bellam, John C. Byrd, Myron S. Czuczman, Luis Fayad, Martha J. Glenn, Jon P. Gockerman, Leo I. Gordon, Nancy Lee Harris, Richard T. Hoppe, Steven M. Horwitz, Christopher R. Kelsey, Youn H. Kim, Susan Krivacic, Ann S. LaCasce, Auayporn Nademanee, Pierluigi Porcu, Oliver Press, Barbara Pro, Nishitha Reddy, Lubomir Sokol, Lode Swinnen, Christina Tsien, Julie M. Vose, Joachim Yahalom, Nadeem Zafar, Maoko Naganuma and Mary A. Dwyer

(and 40% diagnosed at age ≥75 years). 3 Thus, CLL mainly affects “elderly” adults, which poses important challenges regarding the treatment approach in this population. Although chemoimmunotherapy with fludarabine, rituximab, and cyclophosphamide (FCR

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Jae Park

followed by POMP (prednisone, vincristine, methotrexate, 6-mercaptopurine) maintenance in elderly patients with newly diagnosed Philadelphia chromosome negative B-cell acute lymphoblastic leukemia [abstract]. Blood 2018;132(Suppl 1):Abstract 33. As Dr. Park

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Jeffrey E. Lancet and Sergio Giralt

of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial . Blood 2001 ; 98 : 1312 – 1320 . 6. Leith CP Kopecky KJ Godwin J . Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1

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Ashish Rai, Xuesong Han, Zhiyuan Zheng, K. Robin Yabroff and Ahmedin Jemal

estimates. Table 1. Characteristics of Respondents Results We identified 4,588 cancer survivors, of which 2,257 were nonelderly (age 18–64 years) and 2,331 were elderly (age ≥65 years). Respondents' demographic, healthcare access, and

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John C. Byrd

( P =.002). “The additional cost is probably justified by more than 1 year additional progression-free survival. For the elderly, this is a better drug, and we should incorporate it,” he recommended. Figure 1 PI3K inhibition. New

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Andrew D. Zelenetz, Leo I. Gordon, William G. Wierda, Jeremy S. Abramson, Ranjana H. Advani, C. Babis Andreadis, Nancy Bartlett, John C. Byrd, Myron S. Czuczman, Luis E. Fayad, Richard I. Fisher, Martha J. Glenn, Thomas M. Habermann, Nancy Lee Harris, Richard T. Hoppe, Steven M. Horwitz, Christopher R. Kelsey, Youn H. Kim, Susan Krivacic, Ann S. LaCasce, Auayporn Nademanee, Pierluigi Porcu, Oliver Press, Rachel Rabinovitch, Nishitha Reddy, Erin Reid, Ayman A. Saad, Lubomir Sokol, Lode J. Swinnen, Christina Tsien, Julie M. Vose, Lynn Wilson, Joachim Yahalom, Nadeem Zafar, Mary Dwyer and Hema Sundar

frequent grade 3 or higher toxicities with rituximab plus chlorambucil included neutropenia (28%) and infections (14%). The results of the CLL11 study established obinutuzumab plus chlorambucil as the new standard of care for both elderly patients and for

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Miren Gaztañaga and Juanita Crook

less supporting evidence. It may be prescribed as primary treatment in nonmetastatic disease, especially in elderly patients, or in conjunction with brachytherapy. As prostate cancer is the most common cancer in men in the developed world, this wide