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Jeffrey Crawford, Pamela Sue Becker, James O. Armitage, Douglas W. Blayney, Julio Chavez, Peter Curtin, Shira Dinner, Thomas Fynan, Ivana Gojo, Elizabeth A. Griffiths, Shannon Hough, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Mary Mably, Sudipto Mukherjee, Shiven Patel, Lia E. Perez, Adam Poust, Raajit Rampal, Vivek Roy, Hope S. Rugo, Ayman A. Saad, Lee S. Schwartzberg, Sepideh Shayani, Mahsa Talbott, Saroj Vadhan-Raj, Sumithira Vasu, Martha Wadleigh, Peter Westervelt, Jennifer L. Burns and Lenora Pluchino

, vitality, and mental health. 3 The risk of FN is related to the treatment regimen and delivered dose intensity. However, a survey of the literature on randomized clinical trials of chemotherapy in patients with early-stage breast cancer and non

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Zachary Veitch, Omar F. Khan, Derek Tilley, Patricia A. Tang, Domen Ribnikar, Douglas A. Stewart, Xanthoula Kostaras, Karen King and Sasha Lupichuk

/m 2 ) and cycle delay, shown to affect survival. 4 – 7 Historically, reductions in cumulative dose intensity for chemotherapy (average dose across a given regimen) for first- and second-generation regimens (ie, cyclophosphamide/doxorubicin/5

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Jeffrey Crawford, James Armitage, Lodovico Balducci, Pamela Sue Becker, Douglas W. Blayney, Spero R. Cataland, Mark L. Heaney, Susan Hudock, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Brandon McMahon, Hope S. Rugo, Ayman A. Saad, Lee S. Schwartzberg, Sepideh Shayani, David P. Steensma, Mahsa Talbott, Saroj Vadhan-Raj, Peter Westervelt, Michael Westmoreland, Mary Dwyer and Maria Ho

. Selective use of CSFs in patients at increased risk for neutropenic complications may, however, enhance the cost-effectiveness. The risk of FN is usually based on the treatment regimen and delivered dose intensity. A survey of the literature on randomized

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Michaela A. Dinan, Bradford R. Hirsch and Gary H. Lyman

risk of documented infections, 19 FN, 20 and infection-related mortality, 21 while allowing the maintenance or increase of chemotherapy dose-intensity. 22 At the same time, considerable concern exists about the cost of these agents when used outside

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Jeffrey Crawford and George M. Rodgers

, which decreases the relative dose intensity of treatment. Both scenarios can be associated with reduced survival in patients with cancer, according to Jeffrey Crawford, MD, Chief, Division of Medical Oncology, Professor of Medicine, Duke Cancer Institute

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Betsy L. Althaus

increasing dose intensity . Am J Clin Oncol 1999 ; 22 : 38 – 41 . 22. Livingston RB Ellis GK Gralow JR . Dose-intensive vinorelbine with concurrent granulocyte colony-stimulating factor support in paclitaxel-refractory metastatic breast cancer

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Natasha Satkunam, Xuejiao Wei, James J. Biagi, Sulaiman Nanji and Christopher M. Booth

with stage III colon cancer; oxaliplatin was delivered in 281 cases. Details pertaining to dose intensity were available for 102 cases. The authors reported that the median number of cycles was 12 for FOLFOX and 7 for CAPOX. Fifty percent of cases

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b PhD 11 2015 13 13 11 11 1366 1366 1374 1374 jnccn0131366 10.6004/jnccn.2015.0165 Dose Delays, Dose Reductions, and Relative Dose Intensity in Patients With Cancer Who Received Adjuvant or Neoadjuvant Chemotherapy in Community Oncology

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Marina Stasenko, R. Kevin Reynolds, Carolyn Johnston, Melissa Brackman, Karen McLean and Shitanshu Uppal

the antitumor activity of paclitaxel. Dose intensity is also increased, with patients receiving a total of 240 mg/m 2 of paclitaxel over 3 weeks compared with 175 mg/m 2 with the conventional regimen. Unfortunately, this dose-dense treatment

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Ali Bazarbachi and Andrew D. Zelenetz

of 3 components: (1) increased dose-intensity of doxorubicin, cyclophosphamide, and rituximab; (2) sequential consolidation using second-line agents such as ifosfamide, etoposide, and cytarabine; and (3) central nervous system prophylaxis with high