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David H. Moore

. CA Cancer J Clin 2003 ; 53 : 5 – 26 . 2 Fu KK . Biological basis for the interaction of chemotherapeutic agents and radiation therapy . Cancer 1985 ; 55 : 2123 – 2130 . 3 Sinclair WK . Hydroxyurea: Effects on Chinese

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Amol K. Narang and Stephanie A. Terezakis

, radiation therapy (RT) alone was the backbone of management for Hodgkin lymphoma (HL). Despite high tumor control rates with RT alone, large treatment fields were required that included uninvolved lymph nodes at risk. As a result, patients incurred late

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Joseph M. Pepek, Christopher G. Willett and Brian G. Czito

Techniques for the treatment of anal cancer have developed in parallel with technologic advances in radiation therapy (RT). Combined chemotherapy and RT has replaced radical surgical resection as the cornerstone of treatment for anal malignancies

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Andrew H. Ko and Christopher H. Crane

W hen considering the role of radiation therapy in operable and locally advanced pancreatic cancer, it becomes necessary to examine the patterns of locoregional versus systemic failure in these disease settings. For example, data from single

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Lucas K. Vitzthum, Chris Straka, Reith R. Sarkar, Rana McKay, J. Michael Randall, Ajay Sandhu, James D. Murphy and Brent S. Rose

Background Multiple randomized controlled trials have shown that androgen deprivation therapy (ADT) improves outcomes for men with intermediate- or high-risk prostate cancer (PCa) treated with radiation therapy (RT). 1 – 4 These trials used

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Hans Theodor Eich, Jan Kriz and Rolf-Peter Müller

analyses, never as prospective randomized trials, and mostly for radiation therapy only. No substantial data exist for the combined modality treatment of radiotherapy and chemotherapy. Therefore, the HD10 trial was initiated to answer 2 questions for early

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Matthew E. Nielsen, Bruce J. Trock and Patrick C. Walsh

. 17. Stephenson AJ Scardino PT Kattan MW . Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy . J Clin Oncol 2007 ; 25 : 2035 – 2041 . Erratum in: J Clin Oncol 2007;25:4153 . 18

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Kilian E. Salerno

commercial interests with the manufacturers of any products discussed in this article or their competitors. References 1. Whelan TJ Pignol JP Levine MN . Long-term results of hypofractionated radiation therapy for breast cancer . N Engl J

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Richard T. Hoppe

In the past 2 decades, remarkable advances have occurred in radiation therapy technology, including development of inverse treatment planning, improved patient immobilization techniques and organ motion adaptations, precision treatment delivery

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Joseph M. Herman and Albert C. Koong

targeted therapies have not been very effective and, unfortunately, often increase rates of treatment-related toxicity. Radiation therapy has been shown to improve local control, stability of disease progression, and pain control in many stages of