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Holbrook E. Kohrt and Steven E. Coutre

Dick JE . Acute myeloid leukemia . Hematology Am Soc Hematol Educ Program 2001 : 62 – 86 . 4. Appelbaum FR Gundacker H Head DR . Age and acute myeloid leukemia . Blood 2006 ; 107 : 3481 – 3485 . 5. Leith CP Kopecky KJ

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Mikkael A. Sekeres

References 1. Estey EH . How I treat older patients with AML . Blood 2000 ; 96 : 1670 – 1673 . 2. Mayer RJ Davis RB Schiffer CA . Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and

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Daniel A. Pollyea

Introduction From the 1970s until 2017, there was little progress in the frontline treatment of acute myeloid leukemia (AML). Now, according to Daniel A. Pollyea, MD, MS, Associate Professor, University of Colorado School of Medicine, recent drug

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Mark G. Frattini and Peter G. Maslak

Edited by Kerrin G. Robinson

classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML 11 trial . Blood 2001 ; 98 : 1312 – 1320 . 9. Chang C Storer B Scott B . Hematopoietic cell

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Vanderbilt-Ingram Cancer Center

Approximately 13,290 people will be diagnosed with acute myeloid leukemia (AML) in 2008, and 8820 patients will die of the disease. As the population ages, the incidence of AML, along with myelodysplasia, appears to be rising. Clinical trials have led to significant treatment improvements in some areas, primarily acute promyelocytic leukemia. However, recent large clinical trials have highlighted the need for new, innovative strategies, because outcomes for AML patients have not substantially changed in the past 3 decades. The NCCN AML Panel has focused on outlining reasonable treatment options based on recent clinical trials and data from basic science, which may identify new risk factors and treatment approaches. These guidelines attempt to provide a rationale for including several treatment options in some categories, as divergent opinions about the relative risks and benefits of various treatment options have surfaced. Updates for 2009 include new clarifications of some treatment recommendations as well as for defining polymerase chain reaction positivity.

For the most recent version of the guidelines, please visit NCCN.org

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Martin S. Tallman, Eunice S. Wang, Jessica K. Altman, Frederick R. Appelbaum, Vijaya Raj Bhatt, Dale Bixby, Steven E. Coutre, Marcos De Lima, Amir T. Fathi, Melanie Fiorella, James M. Foran, Aric C. Hall, Meagan Jacoby, Jeffrey Lancet, Thomas W. LeBlanc, Gabriel Mannis, Guido Marcucci, Michael G. Martin, Alice Mims, Margaret R. O’Donnell, Rebecca Olin, Deniz Peker, Alexander Perl, Daniel A. Pollyea, Keith Pratz, Thomas Prebet, Farhad Ravandi, Paul J. Shami, Richard M. Stone, Stephen A. Strickland, Matthew Wieduwilt, Kristina M. Gregory, OCN, Lydia Hammond and Ndiya Ogba

Overview Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other tissues. It is the most common form of acute leukemia among

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Farhad Ravandi and Jeffrey L. Jorgensen

. References 1 Dohner H Estey EH Amadori S . Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet . Blood 2010 ; 115 : 453 – 474 . 2 Cheson

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Hany Elmariah and Keith W. Pratz

Background For 40 years, standard therapy for acute myeloid leukemia (AML) has remained infusional cytarabine/anthracycline–based induction chemotherapy to achieve remission, followed typically by high-dose cytarabine consolidative therapy to

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Hans C. Lee, Victor Mulanovich and Yago Nieto

immunosuppression. This report presents 2 patients diagnosed with PML after receiving allogeneic BMTs for acute myeloid leukemia (AML) in the setting of significant T-cell lymphopenia. Case 1 A 69-year-old man was diagnosed with acute myelomonocytic

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Maria R. Baer and Ivana Gojo

Acute Myeloid Leukemia Incidence Increases With Age The incidence of acute myeloid leukemia (AML) increases with age, with a median age at diagnosis of 67 years. 1 As the proportion of older adults in the population increases, AML in older