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Daniel R. Simpson, Parag Sanghvi, and Ajay P. Sandhu

Stereotactic body radiotherapy (SBRT) has become the standard of care for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC). A paucity of published data exists regarding the safety of SBRT use in patients with prior pneumonectomy. This report describes 2 patients with NSCLC and prior pneumonectomy who were treated with lung SBRT and experienced a favorable treatment response with no major adverse treatment effects. The data presented herein are promising and provide early evidence that lung SBRT is a safe and feasible option in this subset of patients.