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Colby J. Hyland, Flora Varghese, Christina Yau, Heather Beckwith, Katia Khoury, William Varnado, Gillian L. Hirst, Robert R. Flavell, A. Jo Chien, Douglas Yee, Claudine J. Isaacs, Andres Forero-Torres, Laura J. Esserman, and Michelle E. Melisko

distant metastasis in the initial staging of breast cancer . Turk J Med Sci 2016 ; 46 : 349 – 360 . 10.3906/sag-1409-1 27511496 7. Nursal GN , Nursal TZ , Aytac HO , . Is PET/CT necessary in the management of early breast cancer? Clin Nucl

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Traci LeMasters, S. Suresh Madhavan, Usha Sambamoorthi, Hannah W. Hazard-Jenkins, Kimberly M. Kelly, and Dustin Long

. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer . N Engl J Med 2004 ; 351 : 971 – 977 . 11. Hughes KS Schnaper LA Bellon JR . Lumpectomy plus tamoxifen with or without irradiation

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John A. Charlson, Emily L. McGinley, Ann B. Nattinger, Joan M. Neuner, and Liliana E. Pezzin

. Geographic variation in Medicare drug spending . N Eng J Med 2010 ; 363 : 405 – 409 . 3. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) . Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15

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Omalkhair Abulkhair, Nagi Saghir, Lobna Sedky, Ahmed Saadedin, Heba Elzahwary, Neelam Siddiqui, Mervat Al Saleh, Fady Geara, Nuha Birido, Nadia Al-Eissa, Sana Al Sukhun, Huda Abdulkareem, Menar Mohamed Ayoub, Fawaz Deirawan, Salah Fayaz, Alaa Kandil, Sami Khatib, Mufid El-Mistiri, Dorria Salem, El Siah Hassan Sayd, Mohammed Jaloudi, Mohammad Jahanzeb, and William I. Gradishar

rates by age and tumor characteristics among US women . Breast Cancer Res 2007 ; 9 : R28 . 6. Early Breast Cancer Trialists' Collaborative Group (EBCTCG) . Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence

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Hiram S. Cody III and Kimberly J. Van Zee

1998 ; 16 : 515 – 521 . 59 Simes RJ Coates AS . Patient preferences for adjuvant chemotherapy of early breast cancer: How much benefit is needed? J Natl Cancer Inst Monogr 2001 ; 146 – 152 .

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Jill R. Tichy, Elgene Lim, and Carey K. Anders

question must provide guidance ( Table 1 ). In the Early Breast Cancer Trialist’s Collaborative Group (EBCTCG) review, ovarian ablation was associated with a significantly decreased risk of recurrence and mortality when compared with placebo. 44 In

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Melinda Telli

Loibl S . Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomized phase 2 trial . Lancet Oncol 2014 ; 15 : 747 – 756 . 2. Sikov WM Berry DA Perou CM . Impact of the

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Stefanie S. Jeffrey, Per Eystein Lønning, and Bruce E. Hillner

; 44 : 671 – 675 . 53 Group EBCTC . Polychemotherapy for early breast cancer: an overview of the randomised trials . Lancet 1998 ; 352 : 930 – 942 . 54 Group EBCTC . Tamoxifen for early breast cancer: An overview of the

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Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Wendy Demark-Wahnefried, Don Dizon, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Grace H. Ku, Elizabeth Kvale, Terry S. Langbaum, Kristin Leonardi-Warren, Mary S. McCabe, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Javid J. Moslehi, Tracey O’Connor, Linda Overholser, Electra D. Paskett, Jeffrey Peppercorn, Muhammad Raza, M. Alma Rodriguez, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole R. McMillian, and Deborah A. Freedman-Cass

physical functional limitations in breast cancer survivors [published online ahead of print May 8, 2014] . J Cancer Surviv . 18. Pan H Gray RG ; on behalf of the Early Breast Cancer Trialists’ Collaborative Group . Effect of obesity in

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Laura Spring, Rachel Greenup, Andrzej Niemierko, Lidia Schapira, Stephanie Haddad, Rachel Jimenez, Suzanne Coopey, Alphonse Taghian, Kevin S. Hughes, Steven J. Isakoff, Leif W. Ellisen, Barbara L. Smith, Michelle Specht, Beverly Moy, and Aditya Bardia

S . Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer . Br J Cancer 2004 ; 91 : 2012 – 2017 . 21. Guarneri V Broglio K Kau SW . Prognostic