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Matthew Zibelman and Elizabeth R. Plimack

papillary, but other subtypes include chromophobe, sarcomatoid, collecting duct, medullary, and various hereditary forms. Patients with metastatic nccRCC have generally demonstrated less responsiveness to the drugs shown to be active in ccRCC. In the TKI era

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Joshua I. Warrick

Brunn nests, particularly on superficial biopsies. 52 Likewise, the invasive “large nested” variant of UC may appear deceptively similar to non-invasive low-grade papillary UC. 53 No study to the author's knowledge has addressed outcomes in

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Donald A. Podoloff, Douglas W. Ball, Edgar Ben-Josef, Al B. Benson III, Steven J. Cohen, R. Edward Coleman, Dominique Delbeke, Maria Ho, David H. Ilson, Gregory P. Kalemkerian, Richard J. Lee, Jay S. Loeffler, Homer A. Macapinlac, Robert J. Morgan Jr., Barry Alan Siegel, Seema Singhal, Douglas S. Tyler, and Richard J. Wong

incidence of thyroid cancer in the United States, 1973–2002 . JAMA 2006 ; 295 : 2164 – 2167 . 151 Albores-Saavedra J Henson DE Glazer E Schwartz AM . Changing patterns in the incidence and survival of thyroid cancer with follicular phenotype—papillary

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Robert J. Motzer, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B. Bolger, Michael A. Carducci, Sam S. Chang, Toni K. Choueiri, Steven L. Hancock, Gary R. Hudes, Eric Jonasch, David Josephson, Timothy M. Kuzel, Ellis G. Levine, Daniel W. Lin, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Thomas W. Ratliff, Bruce G. Redman, Cary N. Robertson, Charles J. Ryan, Joel Sheinfeld, Philippe E. Spiess, Jue Wang, and Richard B. Wilder

less common cell types include papillary, chromophobe, and Bellini duct (collecting duct) tumors. Collecting duct carcinoma constitutes fewer than 1% of kidney cancer cases. Medullary renal carcinoma is a variant of collecting duct renal carcinoma and

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Gary R. Hudes, Michael A. Carducci, Toni K. Choueiri, Peg Esper, Eric Jonasch, Rashmi Kumar, Kim A. Margolin, M. Dror Michaelson, Robert J. Motzer, Roberto Pili, Susan Roethke, and Sandy Srinivas

that targets the hypoxia inducible factors (HIFs) for ubiquitin-mediated degradation. Mutation of the proto-oncogene MET, which codes for the hepatocyte growth factor receptor, is found in the hereditary form of type 1 papillary RCC and in a subset of

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Stephanie L. Lee

. 2. Hay ID . Selective use of radioactive iodine in the postoperative management of patients with papillary and follicular thyroid carcinoma . J Surg Oncol 2006 ; 94 : 692 – 700 . 3. Verburg FA Dietlein M

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Angela Jain, Paula D. Ryan, and Michael V. Seiden

markers for mOCs are more likely to be positive for CK7, CK20, and CEA, whereas only CK20 and CEA are likely to be positive for CRC. Histologically, mOCs are more likely to show a papillary growth pattern, with an expansile pattern of invasion. Metastatic

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Therese B. Bevers, Benjamin O. Anderson, Ermelinda Bonaccio, Sandra Buys, Mary B. Daly, Peter J. Dempsey, William B. Farrar, Irving Fleming, Judy E. Garber, Randall E. Harris, Alexandra S. Heerdt, Mark Helvie, John G. Huff, Nazanin Khakpour, Seema A. Khan, Helen Krontiras, Gary Lyman, Elizabeth Rafferty, Sara Shaw, Mary Lou Smith, Theodore N. Tsangaris, Cheryl Williams, and Thomas Yankeelov

may require additional tissue samples include mucin-producing lesions, potential phyllodes tumor, papillary lesions, radial scars, or other histologies of concern to the pathologist. 77 , 83 , 84 , 90 This recommendation is supported by results of

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Michael Karass, Rohan Bareja, Ethan Shelkey, Panagiotis J. Vlachostergios, Brian D. Robinson, Francesca Khani, Juan Miguel Mosquera, Douglas S. Scherr, Andrea Sboner, Scott T. Tagawa, Ana M. Molina, Olivier Elemento, David M. Nanus, and Bishoy M. Faltas

high-grade papillary muscle-invasive UCB on repeat TURBT. Because her disease remained confined to the pelvis, she underwent a robot-assisted radical cystectomy with ileal conduit urinary diversion and left inguinal lymph node excision (pathologic stage

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Jarred Burkart, Dwight Owen, Manisha H. Shah, Sherif R. Z. Abdel-Misih, Sameek Roychowdhury, Robert Wesolowski, Sigurdis Haraldsdottir, Julie W. Reeser, Eric Samorodnitsky, Amy Smith, and Bhavana Konda

the colon and lung, papillary thyroid cancer, melanoma, and hairy cell leukemia. 8 In BRAF V600E -mutated melanoma, combined BRAF and MEK inhibition has shown superiority to BRAF monotherapy and has proven to be an effective treatment for metastatic