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NCCN Guidelines Insights: Hepatobiliary Cancers, Version 2.2019

Featured Updates to the NCCN Guidelines

Al B. Benson III, Michael I. D’Angelica, Daniel E. Abbott, Thomas A. Abrams, Steven R. Alberts, Daniel A. Anaya, Robert Anders, Chandrakanth Are, Daniel Brown, Daniel T. Chang, Jordan Cloyd, Anne M. Covey, William Hawkins, Renuka Iyer, Rojymon Jacob, Andreas Karachristos, R. Kate Kelley, Robin Kim, Manisha Palta, James O. Park, Vaibhav Sahai, Tracey Schefter, Jason K. Sicklick, Gagandeep Singh, Davendra Sohal, Stacey Stein, G. Gary Tian, Jean-Nicolas Vauthey, Alan P. Venook, Lydia J. Hammond, and Susan D. Darlow

carcinoma (HCC) are increasing. 1 , 2 Risk factors for development of HCC include infection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV), and cirrhosis of the liver (eg, alcohol cirrhosis). 3 Metabolic disorders (ie, obesity, diabetes

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Al B. Benson III, Thomas A. Abrams, Edgar Ben-Josef, P. Mark Bloomston, Jean F. Botha, Bryan M. Clary, Anne Covey, Steven A. Curley, Michael I. D'Angelica, Rene Davila, William D. Ensminger, John F. Gibbs, Daniel Laheru, Mokenge P. Malafa, Jorge Marrero, Steven G. Meranze, Sean J. Mulvihill, James O. Park, James A. Posey, Jasgit Sachdev, Riad Salem, Elin R. Sigurdson, Constantinos Sofocleous, Jean-Nicolas Vauthey, Alan P. Venook, Laura Williams Goff, Yun Yen, and Andrew X. Zhu

hepatic iron and alcohol ingestion in hepatic mutagenesis . Toxicology 2008 ; 254 : 11 – 18 . 26 Singal AK Anand BS . Mechanisms of synergy between alcohol and hepatitis C virus . J Clin Gastroenterol 2007 ; 41 : 761 – 772 . 27

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Katrina S. Pedersen, Kanwal Raghav, and Michael J. Overman

small bowel carcinogenesis, and is another area of research opportunity. Some SBA risk factors have been identified, primarily in retrospective and registry analyses. Among environmental exposures, alcohol and cigarette smoking may lead to increased risk

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Philip J. Saylor and Matthew R. Smith

to women, as one third of all hip fractures occur in men. 57 The 3 most common causes of osteoporosis in men are alcohol abuse, chronic glucocorticoids, and hypogonadism. 58 Available evidence convincingly shows that ADT is detrimental to

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Daniel L. Hall and Jeffrey M. Peppercorn

the COVID-19 global pandemic have only exacerbated high rates of sleep disturbance. This report also identifies factors associated with a greater likelihood of insomnia (eg, breast cancer history, age <65 years, use of alcohol as a sleep aid), although

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Srinivas K. Tantravahi, and Theresa L. Werner

tobacco, alcohol, or illicit drugs. In June 2011 she underwent laparoscopic total hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy. Pathology revealed FIGO grade 1–2 endometrioid adenocarcinoma measuring 4.2 × 3

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Sharon Spencer

. Human Papillomavirus and HNSCC Cancers Human papillomavirus (HPV)–driven oropharyngeal squamous cell carcinomas represent a distinct disease from other HNSCCs, which are traditionally induced by excessive tobacco and alcohol consumption. 2 According

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Azeez Farooki

fracture, low body weight, current cigarette smoking, and excessive alcohol consumption, Dr. Farooki discussed 2 in detail: advancing age and previous fracture. Studies have shown that the 10-year probability of any fracture (except of forearm fractures

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Presenters: Jimmy J. Caudell, David G. Pfister, and Randal S. Weber

among African Americans compared with other ethnic groups. 1 “Historically, HNC diagnosis has been strongly associated with tobacco and alcohol, but for a while we have appreciated the role of Epstein-Barr virus (EBV) as a risk factor for nasopharynx

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Presenter: Robin Kate Kelley

Conference. 1 “Its impact is not to be understated.” Most hepatocellular carcinomas (HCCs) are caused by an underlying liver injury due to toxins, such as alcohol, or viruses, such as hepatitis B virus (HBV) or hepatitis C virus (HCV). “But a very