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Zachary Veitch, Omar F. Khan, Derek Tilley, Domen Ribnikar, Xanthoula Kostaras, Karen King, Patricia Tang, and Sasha Lupichuk

Piccart-Gebhart MJ Gelber RD . 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial . Lancet 2017 ; 389 : 1195 – 1205 . 4. Perez EA Romond EH Suman VJ

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John Charlson, Elizabeth C. Smith, Alicia J. Smallwood, Purushottam W. Laud, and Joan M. Neuner

versus placebo on bone mineral density, bone biomarkers, and plasma lipids in patients with surgically resected early breast cancer . J Clin Oncol 2005 ; 23 : 5126 – 5137 . 5. Gralow JR Biermann JS Farooki A . NCCN Task Force Report: Bone

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William J. Gradishar, Benjamin O. Anderson, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, Daniel F. Hayes, Clifford A. Hudis, Steven J. Isakoff, Britt-Marie E. Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Robert S. Miller, Mark Pegram, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Mary Lou Smith, Hatem Soliman, George Somlo, John H. Ward, Antonio C. Wolff, Richard Zellars, Dorothy A. Shead, and Rashmi Kumar

and predicted sensitivity to a particular treatment (eg, ER/PR and HER2 status). The published results of the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) overview analyses of adjuvant polychemotherapy and tamoxifen show convincing

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew P. Goetz, Lori J. Goldstein, Steven J. Isakoff, Janice Lyons, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena S. Moran, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer . Breast Cancer Res Treat 2006 ; 95 : 279 – 293 . 4. Lucci A McCall LM Beitsch PD

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Margaret M. Kozak, Clare E. Jacobson, Rie von Eyben, Erqi L. Pollom, Melinda Telli, and Kathleen C. Horst

early breast cancer: the randomized clinical FinXX trial . JAMA Oncol 2017 ; 3 : 793 – 800 . 18. Martín M Ruiz Simón A Ruiz Borrego M . Epirubicin plus cyclophosphamide followed by docetaxel versus epirubicin plus docetaxel followed by

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Virginia G. Kaklamani and William J. Gradishar

cancer . Semin Oncol 2001 ; 28 : 389 – 399 . 2 Prowell TM Pazdur R . Pathological complete response and accelerated drug approval in early breast cancer . N Engl J Med 2012 ; 366 : 2438 – 2441 . 3 Wolmark N Wang J Mamounas E

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

Oncology (to view the most recent version of these guidelines, visit NCCN.org ). Additional Workup Directed by Signs and Symptoms The panel has reiterated that routine systemic imaging is not indicated for patients with early breast cancer in the

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Gary H. Lyman

Skipper HE : Kinetics of Mannary Tumor Cell Growth and Implications for Therapy . Cancer 1971 ; 28 : 1479 . 40 Early Breast Cancer Trialists' Collaborative Group . Effects of chemotherapy and hormonal therapy for early breast cancer on

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Gayathri Nagaraj and Cynthia X. Ma

different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials . Lancet 2012 ; 379 : 432 – 444 . 4. Colleoni M Gelber S Coates AS . Influence of endocrine

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

for those with negative axillary nodes). This recommendation is supported by the results of a meta-analysis by the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) showing reduction in 10-year risk of recurrence in those who received whole