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Gerald A. Soff

data showing greater efficacy with DOACs compared with LMWHs, but cautioned about an increased risk of bleeding in patients with genitourinary tract pathology or nephrostomy tubes, or in patients with active gastrointestinal mucosal abnormalities such

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Thomas B. Nealis, Kay Washington, and Rajesh N. Keswani

dysplastic Barrett's. Because esophagectomy may be associated with significant morbidity, endoscopic therapies for premalignant Barrett's esophagus and early EAC have been developed and studied. Pathology of Barrett's Esophagus With the emergence of new

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NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021

Featured Updates to the NCCN Guidelines

Susan M. Swetter, John A. Thompson, Mark R. Albertini, Christopher A. Barker, Joel Baumgartner, Genevieve Boland, Bartosz Chmielowski, Dominick DiMaio, Alison Durham, Ryan C. Fields, Martin D. Fleming, Anjela Galan, Brian Gastman, Kenneth Grossmann, Samantha Guild, Ashley Holder, Douglas Johnson, Richard W. Joseph, Giorgos Karakousis, Kari Kendra, Julie R. Lange, Ryan Lanning, Kim Margolin, Anthony J. Olszanski, Patrick A. Ott, Merrick I. Ross, April K. Salama, Rohit Sharma, Joseph Skitzki, Jeffrey Sosman, Evan Wuthrick, Nicole R. McMillian, and Anita M. Engh

of regional or distant metastatic disease if present. For patients with resected stage III–IV melanoma, adjuvant systemic immune and targeted therapies are an important means of improving disease-free survival. Revisions to Pathology

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Matthew H. Kulke, Al B. Benson III, Emily Bergsland, Jordan D. Berlin, Lawrence S. Blaszkowsky, Michael A. Choti, Orlo H. Clark, Gerard M. Doherty, James Eason, Lyska Emerson, Paul F. Engstrom, Whitney S. Goldner, Martin J. Heslin, Fouad Kandeel, Pamela L. Kunz, Boris W. Kuvshinoff II, Jeffrey F. Moley, Venu G. Pillarisetty, Leonard Saltz, David E. Schteingart, Manisha H. Shah, Stephen Shibata, Jonathan R. Strosberg, Jean-Nicolas Vauthey, Rebekah White, James C. Yao, Deborah A. Freedman-Cass, and Mary A. Dwyer

only 19.5%. 22 In addition to information on histologic classification and stage, the margin status (positive or negative) and the presence of vascular or perineural invasion should be indicated on the pathology report, because they may also have

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Christopher K. Bichakjian, Thomas Olencki, Murad Alam, James S. Andersen, Daniel Berg, Glen M. Bowen, Richard T. Cheney, Gregory A. Daniels, L. Frank Glass, Roy C. Grekin, Kenneth Grossman, Alan L. Ho, Karl D. Lewis, Daniel D. Lydiatt, William H. Morrison, Kishwer S. Nehal, Kelly C. Nelson, Paul Nghiem, Clifford S. Perlis, Ashok R. Shaha, Wade L. Thorstad, Malika Tuli, Marshall M. Urist, Timothy S. Wang, Andrew E. Werchniak, Sandra L. Wong, John A. Zic, Nicole McMillian, Karin Hoffman, and Maria Ho

during the initial development of this guideline. The latest full guideline, including a complete list of updates, is available on the NCCN Web site at NCCN.org . These NCCN Guidelines Insights highlight the addition of the “Principles of Pathology

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Brook Blackmore, Nicole Centers, and Troy Gifford

process. Methods: A patient identification software application (patient ID), utilizing natural language processing technology, was developed to identify positive pathology reports across the enterprise in real time. Patient ID instantly routes those

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NCCN Guidelines® Insights: Breast Cancer, Version 4.2021

Featured Updates to the NCCN Guidelines

William J. Gradishar, Meena S. Moran, Jame Abraham, Rebecca Aft, Doreen Agnese, Kimberly H. Allison, Sarah L. Blair, Harold J. Burstein, Chau Dang, Anthony D. Elias, Sharon H. Giordano, Matthew P. Goetz, Lori J. Goldstein, Sara A. Hurvitz, Steven J. Isakoff, Rachel C. Jankowitz, Sara H. Javid, Jairam Krishnamurthy, Marilyn Leitch, Janice Lyons, Jennifer Matro, Ingrid A. Mayer, Joanne Mortimer, Ruth M. O'Regan, Sameer A. Patel, Lori J. Pierce, Hope S. Rugo, Amy Sitapati, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, Erica M. Stringer-Reasor, Melinda L. Telli, John H. Ward, Kari B. Wisinski, Jessica S. Young, Jennifer L. Burns, and Rashmi Kumar

developed by a multidisciplinary panel of representatives from NCCN Member Institutions with breast cancer–focused expertise in the fields of medical oncology, surgical oncology, radiation oncology, pathology, reconstructive surgery, and patient advocacy

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Harry S. Cooper

intestines . In: Atlas of Tumor Pathology , 3rd Series . Washington, DC : Armed Forces Institute of Pathology ; 2003 . 2. Cooper HS . Intestinal neoplasms . In: Mills SE, Carter D, Greenson JK, et al., eds. Sternberg's Diagnostic

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Jay Gong, Jeffrey P. Gregg, Weijie Ma, Ken Yoneda, Elizabeth H. Moore, Megan E. Daly, Yanhong Zhang, Melissa J. Williams, and Tianhong Li

collapse (solid circle). (C–F) Histologic assessment of different lung pathologies. (C) Hematoxylin-eosin staining revealed LUAD at diagnosis and (D) invasive, well-differentiated, squamous cell carcinoma approximately 3.5 years later at the same location

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Jeremy S. Abramson

compared with placebo (57% vs 19%) and anemia (61% vs 0%). “Interestingly, this benefit was observed exclusively in patients with the plasmacytic or mixed histologic variants; no patients with hyaline vascular pathology responded to this regimen,” he said