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James S. Blachly, Gerard Lozanski, David M. Lucas, Michael R. Grever, Kari Kendra, and Leslie A. Andritsos

); papillary thyroid cancer (up to 69%); malignant melanoma (40%–60%); and hairy cell leukemia (HCL; up to 100% in a landmark paper). 2 – 9 Melanoma and HCL are of particular interest because both diseases have shown dramatic responses to therapy with the

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Thai H. Ho and Eric Jonasch

renal parenchyma. Histologic classifications include clear cell, papillary, chromophobe, and translocation; rare subtypes include renal medullary and collecting duct. Hereditary familial RCC syndromes have yielded clues regarding the molecular

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Nalan Nese, Ruta Gupta, Matthew H. T. Bui, and Mahul B. Amin

Edited by Kerrin G. Robinson

urothelial dysplasia . Mod Pathol 2003 ; 16 : 187 – 191 . 40 Sun W Herrera GA . E-cadherin expression in urothelial carcinoma in situ, superficial papillary transitional cell carcinoma, and invasive transitional cell carcinoma . Hum Pathol

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Robert J. Motzer, Neeraj Agarwal, Clair Beard, Graeme B. Bolger, Barry Boston, Michael A. Carducci, Toni K. Choueiri, Robert A. Figlin, Mayer Fishman, Steven L. Hancock, Gary R. Hudes, Eric Jonasch, Anne Kessinger, Timothy M. Kuzel, Paul H. Lange, Ellis G. Levine, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Bruce G. Redman, Cary N. Robertson, Lawrence H. Schwartz, Joel Sheinfeld, and Jue Wang

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R. Michael Tuttle, Douglas W. Ball, David Byrd, Raza A. Dilawari, Gerard M. Doherty, Quan-Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith C. McCaffrey, John A. Olson Jr., Lee Parks, John A. Ridge, Jatin P. Shah, Steven I. Sherman, Cord Sturgeon, Steven G. Waguespack, Thomas N. Wang, and Lori J. Wirth

men. 7 Thyroid carcinoma has 3 main histologic types: differentiated (including papillary, follicular, and Hürthle cell), medullary, and anaplastic (aggressive undifferentiated tumor). Of 53,856 patients treated for thyroid carcinoma between 1985 and

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Susan M. Domchek, Jill E. Stopfer, and Timothy R. Rebbeck

– 1479 . 5. Struewing JP Watson P Easton DF . Prophylactic oophorectomy in inherited breast/ovarian cancer families . J Natl Cancer Inst Monogr 1995 ; 17 : 33 – 35 . 6. White CD . Papillary intraperitoneal neoplasia resembling

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Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B. Bolger, Sam S. Chang, Toni K. Choueiri, Ithaar H. Derweesh, Shilpa Gupta, Steven L. Hancock, Jenny J. Kim, Timothy M. Kuzel, Elaine T. Lam, Clayton Lau, Ellis G. Levine, Daniel W. Lin, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Elizabeth R. Plimack, Edward N. Rampersaud, Bruce G. Redman, Charles J. Ryan, Joel Sheinfeld, Kanishka Sircar, Brad Somer, Jue Wang, Richard B. Wilder, Mary A. Dwyer, and Rashmi Kumar

RCC has increased by 1.7% per year for the past 10 years. 2 Approximately 90% of renal tumors are RCC, and 85% of these are clear cell tumors. 3 Other less common cell types include papillary, chromophobe, “translocation-type,” and Bellini

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Jacqueline Jonklaas

papillary and follicular thyroid cancer . J Clin Endocrinol Metab 2001 ; 86 : 1447 – 1463 . 53. Morris LF Waxman AD Braunstein GD . The nonimpact of thyroid stunning: remnant ablation rates in 131I-scanned and nonscanned individuals . J Clin

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R. Michael Tuttle and R. Leboeuf

. References 1. Mazzaferri EL Kloos RT . Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer . J Clin Endocrinol Metab 2001 ; 86 : 1447 – 1463 . 2. Hundahl SA Fleming ID Fremgen AM Menck

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Benjamin E. Greer, Wui-Jin Koh, Nadeem Abu-Rustum, Michael A. Bookman, Robert E. Bristow, Susana M. Campos, Kathleen R. Cho, Larry Copeland, Marta Ann Crispens, Patricia J. Eifel, Warner K. Huh, Wainwright Jaggernauth, Daniel S. Kapp, John J. Kavanagh, John R. Lurain III, Mark Morgan, Robert J. Morgan Jr, C. Bethan Powell, Steven W. Remmenga, R. Kevin Reynolds, Angeles Alvarez Secord, William Small Jr, and Nelson Teng

endometrial cancer . Int J Clin Oncol 2007 ; 12 : 31 – 36 . 88 Goff BA Kato D Schmidt RA . Uterine papillary serous carcinoma: patterns of metastatic spread . Gynecol Oncol 1994 , 53 : 264 – 268 . 89 Hendrickson MR Longacre TA