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Angela Jain, Paula D. Ryan, and Michael V. Seiden

for craniectomies, and each lesion was excised over 2 different surgeries. This was followed by whole brain radiation. Figure 1 Liver metastases (A) pretreatment, (B) post FOLFOX (5-FU, leucovorin, and oxaliplatin) and bevacizumab, and (C) post

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Ashley E. Glode, S. Lindsey Davis, Supriya K. Jain, Megan D. Marsh, Lisa J. Wingrove, Tracey E. Schefter, Karyn Goodman, Lindel C.K. Dewberry, Martin D. McCarter, Laura Melton, Michelle Bunch, William T. Purcell, and Stephen Leong

Background: At our institution, the standard treatment recommendation for esophageal cancer patients with stage IB–IIIB disease is for neoadjuvant chemoradiation per the CROSS regimen prior to surgery. This regimen can be difficult for patients to

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Pamala A. Pawloski, Gabriela Vazquez-Benitez, Jeanette Y. Ziegenfuss, Terese A. DeFor, and Elisabeth M. Seburg

and medical records. Time from diagnosis to surgery, chemotherapy, and radiation was measured in weeks and censored when disenrollment, death, or the end of the study period occurred. We assessed patient factors associated with time to chemotherapy

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David M. Brizel, William Lydiatt, and A. Dimitrios Colevas

clinical equipoise exists with respect to various current and experimental treatment regimens. Surgery has historically been the workhorse of HNC treatment. Over the past 20 years, the treatment of OPC has been largely supplanted by radiation

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Robert W. Carlson, Susan Moench, Arti Hurria, Lodovico Balducci, Harold J. Burstein, Lori J. Goldstein, William J. Gradishar, Kevin S. Hughes, Mohammad Jahanzeb, Stuart M. Lichtman, Lawrence B. Marks, Joan S. McClure, Beryl McCormick, Lisle M. Nabell, Lori J. Pierce, Mary Lou Smith, Neal S. Topham, Tiffany A. Traina, John H. Ward, and Eric P. Winer

older woman. A total of 18 task force members represented medical oncology, radiation oncology, surgical oncology, geriatric oncology, geriatrics, plastic surgery, and patient advocacy. All task force members were identified and invited solely by NCCN. A

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William J. Gradishar, Benjamin O. Anderson, Ron Balassanian, Sarah L. Blair, Harold J. Burstein, Amy Cyr, Anthony D. Elias, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Matthew Goetz, Lori J. Goldstein, Clifford A. Hudis, Steven J. Isakoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Meena Moran, Sameer A. Patel, Lori J. Pierce, Elizabeth C. Reed, Kilian E. Salerno, Lee S. Schwartzberg, Karen Lisa Smith, Mary Lou Smith, Hatem Soliman, George Somlo, Melinda Telli, John H. Ward, Dorothy A. Shead, and Rashmi Kumar

more effective treatment. 5 Treatment Approach The treatment of breast cancer includes the treatment of local disease with surgery, radiation therapy, or both, and systemic treatment with chemotherapy, endocrine therapy, biologic therapy, or

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Jaffer A. Ajani, Thomas A. D’Amico, Khaldoun Almhanna, David J. Bentrem, Stephen Besh, Joseph Chao, Prajnan Das, Crystal Denlinger, Paul Fanta, Charles S. Fuchs, Hans Gerdes, Robert E. Glasgow, James A. Hayman, Steven Hochwald, Wayne L. Hofstetter, David H. Ilson, Dawn Jaroszewski, Kory Jasperson, Rajesh N. Keswani, Lawrence R. Kleinberg, W. Michael Korn, Stephen Leong, A. Craig Lockhart, Mary F. Mulcahy, Mark B. Orringer, James A. Posey, George A. Poultsides, Aaron R. Sasson, Walter J. Scott, Vivian E. Strong, Thomas K. Varghese Jr, Mary Kay Washington, Christopher G. Willett, Cameron D. Wright, Debra Zelman, Nicole McMillian, and Hema Sundar

complete and most recent version of these guidelines, visit NCCN.org ). Staging The TNM classification developed by the AJCC in 2002 was based on pathologic review of the surgical specimen in patients who underwent surgery as primary therapy. The

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Srinivas K. Tantravahi, and Theresa L. Werner

management of early-stage tumors and treatment failure with isolated local recurrence. In medically operable patients, total hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymph node dissection is the recommended surgery for

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Armin Shahrokni, Bella Marie Vishnevsky, Brian Jang, Saman Sarraf, Koshy Alexander, Soo Jung Kim, Robert Downey, Anoushka Afonso, and Beatriz Korc-Grodzicki

Background For many cancers, surgery remains the primary curative treatment. 1 – 3 Geriatric patients experience increased rates of surgical complications compared with younger patients, leading to decreased long-term survival and delayed recovery

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Mandy R. Sakamoto, Megan Eguchi, Christine M. Azelby, Jennifer R. Diamond, Christine M. Fisher, Virginia F. Borges, Cathy J. Bradley, and Peter Kabos

prescribing opioids in patients with cancer focus on relieving acute pain or pain associated with advanced disease. 13 – 16 A recent study of patients with cancer undergoing curative-intent surgery found that 10.4% had new persistent opioid use at 1 year