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Jun Gong, Chongkai Wang, Peter P. Lee, Peiguo Chu, and Marwan Fakih

decreased in size. Because of significant fatigue, the patient was transitioned to maintenance 5-FU, leucovorin, and bevacizumab starting from cycle 5. He received an additional 11 cycles of maintenance 5-FU, leucovorin, and bevacizumab (16 cycles overall

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Emily H. Castellanos, Sheau-chiann Chen, Hillary Drexler, and Leora Horn

.79–0.94), adjusted for anticipated benefit and toxicity grades. For example, 32.5% of patients stated they would decline curative intent treatment if grade 2 vomiting were expected versus 10.6% if grade 2 rash were expected. Fatigue also had a strong impact on

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Iulia Giuroiu and Diane Reidy-Lagunes

.gov identifier: NCT01010126). However, his treatment course was complicated by grade 3 mucositis, grade 2 thrombocytopenia, and grade 2 fatigue, which led to disenrollment from the trial in March 2010 despite a dose reduction. In August 2010, the patient again

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Elisabeth Kenne Sarenmalm, Salmir Nasic, Cecilia Håkanson, Joakim Öhlén, Eva Carlsson, Monica E. Pettersson, and Richard Sawatzky

, cognitive, emotional, and social), 3 symptom subscales (fatigue, pain, nausea/vomiting), and 6 single-item scales (dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). The QLQ-C30 also generates a global health status based

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Presenters: Chad A. LaGrange, M. Dror Michaelson, and Colleen H. Tetzlaff

(Figure 1). The patient elected to receive full-dose pazopanib. The dose was reduced from 800 mg/day to 600 mg/day due to fatigue. After 10 months, he developed progressive disease. Preferred subsequent therapy is cabozantinib, nivolumab monotherapy, or

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Emily van Seventer, J. Peter Marquardt, Amelie S. Troschel, Till D. Best, Nora Horick, Chinenye Azoba, Richard Newcomb, Eric J. Roeland, Michael Rosenthal, Christopher P. Bridge, Joseph A. Greer, Areej El-Jawahri, Jennifer Temel, Florian J. Fintelmann, and Ryan D. Nipp

particularly at risk for experiencing high symptom burden and loss of muscle. 16 – 18 Patients with muscle loss often require hospital-level care to address treatment adverse effects and high symptom burden (eg, pain, fatigue, nausea). 19 Notably

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included Table 1. CDK 4/6 Inhibitors neutropenia, anemia, and fatigue. No cases of febrile neutropenia were observed. However, an increased rate of grade 3/4 infections and pulmonary embolism was seen in the palbociclib/letrozole arm (5% vs 0

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Jimmie C. Holland, Barbara Andersen, William S. Breitbart, Bruce Compas, Moreen M. Dudley, Stewart Fleishman, Caryl D. Fulcher, Donna B. Greenberg, Carl B. Greiner, Rev. George F. Handzo, Laura Hoofring, Paul B. Jacobsen, Sara J. Knight, Kate Learson, Michael H. Levy, Matthew J. Loscalzo, Sharon Manne, Randi McAllister-Black, Michelle B. Riba, Kristin Roper, Alan D. Valentine, Lynne I. Wagner, and Michael A. Zevon

, dramatic advances in early detection and treatment options have increased overall survival rates in patients of all ages with cancer. At the same time, these improved treatment options are also associated with substantial long-term side effects. Fatigue

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Gary R. Hudes, Michael A. Carducci, Toni K. Choueiri, Peg Esper, Eric Jonasch, Rashmi Kumar, Kim A. Margolin, M. Dror Michaelson, Robert J. Motzer, Roberto Pili, Susan Roethke, and Sandy Srinivas

associated with these therapies could be caused by regression of capillaries around thyroid follicles. Clinical or laboratory evidence of hypothyroidism has been found in a significant proportion of patients on sunitinib and may contribute to fatigue in these

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George M. Rodgers III, Pamela Sue Becker, Morey Blinder, David Cella, Asher Chanan-Khan, Charles Cleeland, Peter F. Coccia, Benjamin Djulbegovic, Jeffrey A. Gilreath, Eric H. Kraut, Ursula A. Matulonis, Michael M. Millenson, Denise Reinke, Joseph Rosenthal, Rowena N. Schwartz, Gerald Soff, Richard S. Stein, Gordana Vlahovic, and Alva B. Weir III

symptoms; comorbidities; family history; and exposure to antineoplastic drugs and radiation. Common complaints are syncope, exercise dyspnea, headache, vertigo, chest pain, fatigue (disruptive to work and daily activities), and abnormal menstruation in