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Presenters: Robert Pilarski, Jennifer M. Weiss, Susan M. Domchek, and Moderated by Tuya Pal

of individuals with variants in these genes. “We know that risk based on family history, known exposures, lifestyle, and issues such as smoking and obesity can all help determine a personalized plan for individuals who have mutations in these moderate

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Margaret A. Tempero, Mokenge P. Malafa, Mahmoud Al-Hawary, Stephen W. Behrman, Al B. Benson III, Dana B. Cardin, E. Gabriela Chiorean, Vincent Chung, Brian Czito, Marco Del Chiaro, Mary Dillhoff, Timothy R. Donahue, Efrat Dotan, Cristina R. Ferrone, Christos Fountzilas, Jeffrey Hardacre, William G. Hawkins, Kelsey Klute, Andrew H. Ko, John W. Kunstman, Noelle LoConte, Andrew M. Lowy, Cassadie Moravek, Eric K. Nakakura, Amol K. Narang, Jorge Obando, Patricio M. Polanco, Sushanth Reddy, Marsha Reyngold, Courtney Scaife, Jeanne Shen, Charles Vollmer Jr., Robert A. Wolff, Brian M. Wolpin, Beth Lynn, and Giby V. George

cancer than white Americans. 2 , 3 The incidence of pancreatic cancer in the United States increased from 1999 to 2008, possibly because of the increasing prevalence of obesity, an aging population, and other unknown factors. 3 – 5 Mortality rates have

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Dawn Provenzale, Samir Gupta, Dennis J. Ahnen, Travis Bray, Jamie A. Cannon, Gregory Cooper, Donald S. David, Dayna S. Early, Deborah Erwin, James M. Ford, Francis M. Giardiello, William Grady, Amy L. Halverson, Stanley R. Hamilton, Heather Hampel, Mohammad K. Ismail, Jason B. Klapman, David W. Larson, Audrey J. Lazenby, Patrick M. Lynch, Robert J. Mayer, Reid M. Ness, Scott E. Regenbogen, Niloy Jewel Samadder, Moshe Shike, Gideon Steinbach, David Weinberg, Mary Dwyer, and Susan Darlow

completed less than 2 years of the intervention. Subgroup analyses from this trial showed that the association between obesity and CRC in patients with Lynch syndrome may be attenuated by taking daily aspirin. 81 However, limitations of the CAPP2 trial

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Michael B. Streiff, Paula L. Bockenstedt, Spero R. Cataland, Carolyn Chesney, Charles Eby, John Fanikos, Patrick F. Fogarty, Shuwei Gao, Julio Garcia-Aguilar, Samuel Z. Goldhaber, Hani Hassoun, Paul Hendrie, Bjorn Holmstrom, Kimberly A. Jones, Nicole Kuderer, Jason T. Lee, Michael M. Millenson, Anne T. Neff, Thomas L. Ortel, Judy L. Smith, Gary C. Yee, and Anaadriana Zakarija

, 14 , 21 and obesity was also identified as a risk factor. 21 - 24 Evidence also shows that prechemotherapy thrombocytosis, 24 - 26 leukocytosis, 24 and hemoglobin level less than 10 g/dL 24 , 25 are predictive of VTE in patients undergoing

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Pancreatic Adenocarcinoma, Version 2.2012

Featured Updates to the NCCN Guidelines

Margaret A. Tempero, J. Pablo Arnoletti, Stephen W. Behrman, Edgar Ben-Josef, Al B. Benson III, Ephraim S. Casper, Steven J. Cohen, Brian Czito, Joshua D. I. Ellenhorn, William G. Hawkins, Joseph Herman, John P. Hoffman, Andrew Ko, Srinadh Komanduri, Albert Koong, Wen Wee Ma, Mokenge P. Malafa, Nipun B. Merchant, Sean J. Mulvihill, Peter Muscarella II, Eric K. Nakakura, Jorge Obando, Martha B. Pitman, Aaron R. Sasson, Anitra Tally, Sarah P. Thayer, Samuel Whiting, Robert A. Wolff, Brian M. Wolpin, Deborah A. Freedman-Cass, and Dorothy A. Shead

: 277 – 300 . 3 Arnold LD Patel AV Yan Y . Are racial disparities in pancreatic cancer explained by smoking and overweight/obesity? Cancer Epidemiol Biomarkers Prev 2009 ; 18 : 2397 – 2405 . 4 StatBite . U.S. pancreatic cancer

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Linda A. Jacobs and David J. Vaughn

obesity. 30 It is associated with cardiovascular morbidity and mortality, and has been described as a late complication among TC survivors. 31 , 32 In a study of 589 survivors who had unilateral orchiectomy, the prevalence of metabolic syndrome and

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Renee W. Pinsky and Mark A. Helvie

and glandular tissue. In the setting of obesity, absolute measurement of density may be more significant. The heritability of breast density has been examined in several classic twin studies. Both Boyd et al. 29 and Ursin et al. 13 showed that

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Linda S. Overholser and Carlin Callaway

, dyslipidemia, obesity, diabetes mellitus, unhealthy dietary habits, and smoking, contribute not only to CVD but also to cancer, and can also impact the course of cancer survivorship. These risk factors are also targets of preventive health counseling, screening

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Daphne Y. Lichtensztajn, John T. Leppert, James D. Brooks, Sumit A. Shah, Weiva Sieh, Benjamin I. Chung, Scarlett L. Gomez, and Iona Cheng

management was contraindicated and appropriately not received. However, it is unlikely that differences in comorbidity burden would explain the observed disparity. Although Latinos have a higher prevalence of diabetes and obesity, the prevalence of

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Daniel Boakye, Viola Walter, Lina Jansen, Uwe M. Martens, Jenny Chang-Claude, Michael Hoffmeister, and Hermann Brenner

% overall) and diabetes (16%). Median age of the participants was 69 years. Comorbidity was particularly common in men, older and underweight/obese patients, former smokers, those recently diagnosed, those with right-sided colon cancer and stage I–II disease