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David S. Ettinger, Gregory J. Riely, Wallace Akerley, Hossein Borghaei, Andrew C. Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D’Amico, Todd L. Demmy, Ramaswamy Govindan, Frederic W. Grannis Jr, Stefan C. Grant, Leora Horn, Thierry M. Jahan, Ritsuko Komaki, Feng-Ming (Spring) Kong, Mark G. Kris, Lee M. Krug, Rudy P. Lackner, Inga T. Lennes, Billy W. Loo Jr, Renato Martins, Gregory A. Otterson, Jyoti D. Patel, Mary C. Pinder-Schenck, Katherine M. Pisters, Karen Reckamp, Eric Rohren, Theresa A. Shapiro, Scott J. Swanson, Kurt Tauer, Douglas E. Wood, Stephen C. Yang, Kristina Gregory and Miranda Hughes

Thymomas are the most common primary tumor in the anterior mediastinum, although they are rare (1.5 cases/million). 1 - 3 Thymic carcinomas are very rare. Thymomas and thymic carcinomas originate in the thymus. Although thymomas can spread locally, they

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Ronan J. Kelly

thymomas (types A, AB, B1, B2, and B3) from thymic carcinomas (type C) based on the morphology of epithelial tumor cells (with increasing degree of atypia along the spectrum from type A to C), proportion of lymphocytic involvement, and resemblance to normal

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David S. Ettinger, Wallace Akerley, Gerold Bepler, Matthew G. Blum, Andrew Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Ramaswamy Govindan, Frederic W. Grannis Jr., Thierry Jahan, David H. Johnson, Anne Kessinger, Ritsuko Komaki, Feng-Ming Kong, Mark G. Kris, Lee M. Krug, Quynh-Thu Le, Inga T. Lennes, Renato Martins, Janis O'Malley, Raymond U. Osarogiagbon, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, Scott J. Swanson, Douglas E. Wood and Stephen C. Yang

Overview Masses in the anterior mediastinum include neoplasms (e.g., thymomas, lymphomas, thymic carcinomas, thymic carcinoids, thymolipomas, germ cell tumors, parathyroid adenomas) or nonneoplastic conditions (e.g., intrathoracic goiter

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Richard T. Cheney

, and seen in 25% to 40% of patients with thymoma. A spectrum of other autoimmune disorders of neuromuscular, hematologic, dermatologic, endocrine, renal, or hepatic origin has been described. 5 Thymic carcinomas are virtually never associated

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NCCN Guidelines® Updates The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Thymomas and Thymic Carcinomas and for Penile Cancer published in this issue (pages 562 and 594, respectively) include the latest updates. To

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10.6004/jnccn.2013.0071 Thymomas and Thymic Carcinomas Ettinger David S. MD Riely Gregory J. MD, PhD Akerley Wallace MD Borghaei Hossein DO, MS Chang Andrew C. MD Cheney Richard T. MD Chirieac Lucian R. MD D

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Frank C. Detterbeck

rarer and need an organized effort. ITMIG has launched work groups focused on thymic carcinoma and thymic carcinoids, and discussion of other mediastinal malignancies is underway. Molecular characterization of tumors is providing new insights, and

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Esophagogastric Junction Cancers Gastric Cancer Malignant Pleural Mesothelioma Melanoma Ovarian Cancer Penile Cancer Small Cell Lung Cancer Thymomas and Thymic Carcinomas NCCN Imaging AUC are an easy-to-use, single source for AUC pertaining to

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.2017 Squamous Cell Skin Cancer, Version 1.2017 Thymomas and Thymic Carcinomas, Version 1.2017 Launched in March 2017, the NCCN RT Compendium now includes recommendations from 33 NCCN Guidelines. Additional cancer types will be published on a rolling

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David S. Ettinger, Wallace Akerley, Hossein Borghaei, Andrew C. Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Ramaswamy Govindan, Frederic W. Grannis Jr, Stefan C. Grant, Leora Horn, Thierry M. Jahan, Ritsuko Komaki, Feng-Ming (Spring) Kong, Mark G. Kris, Lee M. Krug, Rudy P. Lackner, Inga T. Lennes, Billy W. Loo Jr, Renato Martins, Gregory A. Otterson, Jyoti D. Patel, Mary C. Pinder-Schenck, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, Theresa A. Shapiro, Scott J. Swanson, Kurt Tauer, Douglas E. Wood, Stephen C. Yang, Kristina Gregory and Miranda Hughes

lung cancer (eg, squamous cell carcinoma, large cell carcinoma). 21 Other types of thoracic cancer are discussed in the NCCN Guidelines for Malignant Pleural Mesothelioma, Small Cell Lung Cancer, and Thymomas and Thymic Carcinomas (to view the most