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Counterpoint: Intraperitoneal Chemotherapy: An Investigational Treatment in Ovarian Cancer

Robert F. Ozols

Intraperitoneal (IP) chemotherapy in ovarian cancer has been studied since 1978. Numerous phase II trials have been performed, which have shown that higher levels can be obtained in the peritoneal cavity compared with systemic circulation after administration of cytoxic agents in a large volume via a semi-permanent catheter. Three randomized trials have been performed in patients with ovarian cancer comparing different IP regimens to standard therapy with intravenous agents. The last two trials from the Gynecologic Oncology Group (GOG) and the Southwest Oncology Group (SWOG) compared two different IP regimens versus standard therapy with intravenous cisplatin plus paclitaxel. Although an improvement in progression-free survival was reported for the IP regimens, they have been associated with unacceptable toxicity, and no IP regimen can be considered standard therapy. Maintenance therapy with IP cisplatin also failed to improve survival in patients who obtained complete remission after intravenous chemotherapy. The GOG is considering another phase III trial of IP therapy that will compare a carboplatin-based regimen versus standard therapy with intravenous paclitaxel plus carboplatin. Unless such a trial shows an improvement in clinical outcome, intravenous carboplatin plus paclitaxel remains the standard of care and IP chemotherapy should not be used outside of a clinical trial.

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Therapy of Adenocarcinoma of Unknown Primary: Are We Making Progress?

F. Anthony Greco

. Anticancer Res 2004 ; 24 : 297 – 301 . 35. Briasoulis E Kalofonos H Bafaloukos D . Carboplatin plus paclitaxel in unknown primary cancer: a phase II Hellenic Cooperative Oncology Group study . J Clin Oncol 2000 ; 18 : 3101 – 3107 . 36

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Updates to Treatment of Recurrent Metastatic Head and Neck Cancers

Presented by: Cristina P. Rodriguez

head and neck squamous cell carcinoma . J Clin Oncol 2023 ; 41 ( Suppl ): Abstract 6005 . 11. Dzienis MR , Cundom JE , Fuentes CS , Pembrolizumab plus carboplatin plus paclitaxel as first-line therapy in recurrent/metastatic head and

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NCCN Guidelines® Insights: Ovarian Cancer, Version 3.2022

Featured Updates to the NCCN Guidelines

Deborah K. Armstrong, Ronald D. Alvarez, Floor J. Backes, Jamie N. Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Lee-may Chen, Viola C. Chitiyo, Mihaela Cristea, Maria DeRosa, Eric L. Eisenhauer, David M. Gershenson, Heidi J. Gray, Rachel Grisham, Ardeshir Hakam, Angela Jain, Amer Karam, Gottfried E. Konecny, Charles A. Leath III, Gary Leiserowitz, Joyce Liu, Lainie Martin, Daniela Matei, Michael McHale, Karen McLean, David S. Miller, Sanja Percac-Lima, Steven W. Remmenga, John Schorge, Daphne Stewart, Premal H. Thaker, Roberto Vargas, Andrea Wahner Hendrickson, Theresa L. Werner, Emese Zsiros, Mary A. Dwyer, and Lisa Hang

, Rousseau F , Mouret-Reynier MA , Efficacy and safety of first-line single-agent carboplatin vs carboplatin plus paclitaxel for vulnerable older adult women with ovarian cancer: a GINECO/GCIG randomized clinical trial . JAMA Oncol 2021 ; 7 : 853

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Current Recommendations for Systemic Therapy of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Matthew G. Fury and David G. Pfister

residual toxicities from prior cisplatin-based therapy. Carboplatin plus paclitaxel, both in every-3-week 24 , 25 and weekly 26 dosing schedules, has been evaluated in phase II studies with a wide range of reported response rates (26%–52%) and median

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EGFR-Mutant Non–Small Cell Lung Cancer in the Era of Precision Medicine: Importance of Germline EGFR T790M Testing

Ammar Sukari, Misako Nagasaka, and Erin Wakeling

the past decade, there have been tremendous advancements in the management of advanced NSCLC, particularly in molecularly targeted therapy. In the IPASS trial, which randomized 1,217 patients to either gefitinib or carboplatin plus paclitaxel

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Thymic Malignancies*

David S. Ettinger, Wallace Akerley, Gerold Bepler, Matthew G. Blum, Andrew Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Ramaswamy Govindan, Frederic W. Grannis Jr., Thierry Jahan, David H. Johnson, Anne Kessinger, Ritsuko Komaki, Feng-Ming Kong, Mark G. Kris, Lee M. Krug, Quynh-Thu Le, Inga T. Lennes, Renato Martins, Janis O'Malley, Raymond U. Osarogiagbon, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, Scott J. Swanson, Douglas E. Wood, and Stephen C. Yang

treatment for advanced invasive thymoma with cisplatin, doxorubicin, and methylprednisolone . J Thorac Oncol 2007 ; 2 : 73 – 78 . 31. Lemma GL Loehrer PJ Sr Lee JW . A phase II study of carboplatin plus paclitaxel in advanced thymoma or thymic

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Nonoperative Treatment of Large (5–7 cm), Node-Negative Non–Small Cell Lung Cancer Commonly Deviates From NCCN Guidelines

Craig S. Schneider, Robert A. Oster, Aparna Hegde, Michael C. Dobelbower, John M. Stahl, and Adam J. Kole

, Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial

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Carcinoma of Unknown Primary: Focused Evaluation

Gauri R. Varadhachary

Bafaloukos D . Carboplatin plus paclitaxel in unknown primary carcinoma: a phase II Hellenic Cooperative Oncology Group study . J Clin Oncol 2000 ; 18 : 3101 – 3107 . 6 Culine S Lortholary A Voigt JJ . Cisplatin in combination with either

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Chemotherapy-Induced Peripheral Neuropathy in Patients With Gastroesophageal Cancer

Merel J.M. van Velzen, Marieke Pape, Mirjam A.G. Sprangers, Jessy Joy van Kleef, Bianca Mostert, Laurens V. Beerepoot, Marije Slingerland, Elske C. Gootjes, Ronald Hoekstra, Lonneke V. van de Poll-Franse, Nadia Haj Mohammad, and Hanneke W.M. van Laarhoven

capecitabine or 5-fluorouracil plus oxaliplatin (78%). Other regimens included carboplatin plus paclitaxel (3%) and FLOT. Table 1. Baseline Characteristics at Primary Diagnosis CIPN Over Time Supplementary Table S1 shows the number of