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Jeffrey K. Belkora, David W. Hutton, Dan H. Moore, and Laura A. Siminoff

P atients with breast cancer who are at relatively low risk for recurrence or mortality after local therapy (surgery with or without radiation) face a “grey zone” decision about whether to undergo adjuvant therapy. 1 The choice of therapy

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Robert W. Carlson, Elizabeth Brown, Harold J. Burstein, William J. Gradishar, Clifford A. Hudis, Charles Loprinzi, Eleftherios Paul Mamounas, Edith A. Perez, Kathleen Pritchard, Peter Ravdin, Abram Recht, George Somlo, Richard L. Theriault, Eric P. Winer, Antonio C. Wolff, and for the NCCN Adjuvant Therapy for Breast Cancer Task Force

NCCN Adjuvant Therapy for Breast Cancer Task Force Members *Robert W. Carlson, MD / Chair#†  ¶¶ Stanford Hospital and Clinics Donald A. Berry, PhD††  The University of Texas M. D. Anderson Cancer Center *Elizabeth Brown, MD  National Comprehensive

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Katherine Van Loon and Alan P. Venook

Adjuvant therapy for colon cancer evolved in an additive fashion. In the 1980s, 5-fluorouracil (5-FU) administered as a daily bolus regimen made the first positive impact of any therapy on colon cancer survival. 1 The ensuing decade of research

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Jashodeep Datta, Matthew T. McMillan, Eric K. Shang, Ronac Mamtani, Russell S. Lewis Jr, Rachel R. Kelz, Ursina Teitelbaum, John P. Plastaras, Jeffrey A. Drebin, Douglas L. Fraker, Giorgos C. Karakousis, and Robert E. Roses

incorporated into practice guidelines for GA management in the United States. Subsequently, several retrospective population-based studies have reaffirmed the benefit of adjuvant therapy in patients undergoing curative-intent gastrectomy. 7 – 9 Based on these

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Yvonne H. Sada, Brandon G. Smaglo, Joy C. Tan, Hop S. Tran Cao, Benjamin L. Musher, and Nader N. Massarweh

Although perioperative chemotherapy and postoperative chemoradiation are the 2 evidence-based options for gastric cancer, 4 , 6 ongoing multicenter trials are investigating whether strategies that move most or all of the adjuvant therapy to the

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Michael S. Sabel and Vernon K. Sondak

: 3635 – 3648 . 2 Dickler MN Coit DG Myers ML . Adjuvant therapy of malignant melanoma . Surg Oncol Clin N Am 1997 ; 6 : 793 – 812 . 3 Pfeffer LM Dinarello CA Herberman RB . Biological properties of recombinant alpha

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John Khoury, David Macari, Daniel Ezekwudo, Ayoda Werede, and Ishmael A. Jaiyesimi

Background: There is controversy surrounding the benefit of adjuvant therapy for patients with pT2N0, stage IB gastric adenocarcinoma following surgical resection. Methods: Patients with T2N0 gastric adenocarcinoma (tumor invasion into the

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Leslie A. Fecher and Keith T. Flaherty

alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684 . J Clin Oncol 1996 ; 14 : 7 – 17 . 11 Kirkwood J Manola J Ibrahim J . A pooled analysis of eastern cooperative

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Christopher P. Chung, Carolyn Behrendt, Louise Wong, Sarah Flores, and Joanne E. Mortimer

Questionnaire (IIQ-7) 15 before and 3 months after initiation of (neo)adjuvant therapy. Patients with metastatic cancer or currently or previously undergoing treatment by a urologist were excluded from participation. Participants were approached by the treating

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Scott M. Schuetze and Michael E. Ray

1995 ; 72 : 469 – 475 . 24 Zalupski MM Ryan JR Hussein ME Balker LH . Defining the role of adjuvant chemotherapy for patients with soft tissue sarcoma of the extremities . In: Salmon SE , ed. Adjuvant Therapy of Cancer VII. Philadelphia