of 60 cases, care was nonconcordant in 8. Among those cases, 1 patient was advised to have chemotherapy but refused; another patient’s record did not document a recommendation for adjuvant therapy; and 5 patients received treatment but not within the
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Quality Improvement Project: Opportunities for Improvement
Nora M. Hansen, Sally Anne Scherer, and Seema Khan
Active Systemic Treatment of Pancreatic Cancer
Margaret Tempero
margin,” she said. Dr. Tempero briefly reviewed some of the representative adjuvant therapy clinical trials conducted in pancreatic cancer, focusing primarily on the relatively recent phase III ESPAC-4 trial of gemcitabine/capecitabine 1 and the
Genomic Medicine Takes the Stage, Again!
Margaret Tempero
reason that in the adjuvant setting, we could probably identify diagnostic tools to predict outcome, and thus need for adjuvant treatment, across all disease sites. Actually, folks are working on that with a fair bit of success. But adjuvant therapy is
CLO23-040: Electrocardiographic Findings in Cancer Patients Receiving Chemotherapy From the Colombian Coffee Triangle Region
Andres Garcia, David Medina, Alejandra Palacio, Andrés Vallejo, Luz Adriana Díaz, Juan Darío Franco, Tatiana Taborda, and María José Rojas
-IV). In chemotherapy indications, 31.3% were prescribed for palliative care, with the same percentage for adjuvant therapy and 18% for neoadjuvant and hormonal treatment, respectively. The most frequently prescribed antineoplastic agents were taxanes
Pharmacogenetics of Tamoxifen: Who Should Undergo CYP2D6 Genetic Testing?
Michaela J. Higgins, James M. Rae, David A. Flockhart, Daniel F. Hayes, and Vered Stearns
adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial . Lancet Oncol 2008 ; 9 : 45 – 53 . 48 Coates AS Keshaviah A Thurlimann B . Five years of letrozole compared with tamoxifen as initial adjuvant therapy for
Ten Years of Progress in Melanoma
John A. Thompson
-positives. PET/CT may be more useful than conventional CT in the workup of patients who have relatively high pretest probabilities of occult metastatic disease (eg, patients with stage IIIB and IIIC melanoma). Treatment Adjuvant Therapy High
Clinical Consequences of Altering the Definition of HER2-Positive Breast Cancer to Exclude Group 2, HER2-Negative Disease
Steven Sorscher
HER2 copy number is less than 4 signals/cell is that….” 2 Based on the pre-2018 ASCO/CAP HER2 classification, whether being used as adjuvant therapy or therapy for metastatic HER2-positive disease, the FDA-approved anti-HER2 therapies offer truly
Validation of the PREDICT Prognostication Tool in US Patients With Breast Cancer
Nickolas Stabellini, Lifen Cao, Christopher W. Towe, Megan E. Miller, Artur H. Sousa-Santos, Amanda L. Amin, and Alberto J. Montero
,700 breast cancer–related deaths are expected. 2 Due to steady progress in early breast cancer diagnosis and treatment, 5-year overall survival (OS) continues to improve. 3 Accurate estimates of survival and the impact of different adjuvant therapies in
Systemic Management of Colorectal Cancer
Wells A. Messersmith
treatment with the best chance of success. Adjuvant Therapy Although 11 agents have been approved by the FDA for CRC, only 3 are used in the adjuvant setting (fluorouracil [5-FU], capecitabine, and oxaliplatin) and only 2 (cetuximab and panitumumab
HSR20-102: Quality Outcomes in Colon Cancer
Michelle Moskal and Neeharika S. Makani
, only 6.3% of high risk stage II and 45.5% of stage III patients received adjuvant therapy. Data showed 100% compliance with initiation of adjuvant 5-FU based chemotherapy within 12 weeks post surgery, which is recommended in high risk stage II and III