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Small Cell Lung Cancer

Gregory P. Kalemkerian, Wallace Akerley, Paul Bogner, Hossein Borghaei, Laura Chow, Robert J. Downey, Leena Gandhi, Apar Kishor P. Ganti, Ramaswamy Govindan, John C. Grecula, James Hayman, Rebecca Suk Heist, Leora Horn, Thierry M. Jahan, Marianna Koczywas, Cesar A. Moran, Harvey B. Niell, Janis O'Malley, Jyoti D. Patel, Neal Ready, Charles M. Rudin, and Charles C. Williams Jr.

carcinoma differentiation. This finding is more commonly detected in specimens from previously treated patients and suggests that pulmonary carcinogenesis occurs in a pluripotent stem cell capable of differentiation along divergent pathways. Although 95

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Liver-Directed Therapies for Hepatocellular Carcinoma

Cletus A. Arciero and Elin R. Sigurdson

The authors have received a grant of less than $10,000 from the Sanofi Medical Advisory Board. References 1. Thomas MB Zhu AX . Hepatocellular carcinoma: the need for progress . J Clin Oncol 2005 ; 23 : 2892 – 2899

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Exceptional Response to Temsirolimus in a Metastatic Clear Cell Renal Cell Carcinoma With an Early Novel MTOR-Activating Mutation

Juan Francisco Rodríguez-Moreno, María Apellaniz-Ruiz, Juan María Roldan-Romero, Ignacio Durán, Luis Beltrán, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, Jesus García-Donas, and Cristina Rodríguez-Antona

Treatment of advanced renal cell carcinoma (RCC) has changed drastically in the past decade. The mTORC1 inhibitors, everolimus and temsirolimus (also known as rapalogs ), have been shown to be key drugs for use in first-line treatment 1 and

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Transplantation for Hepatocellular Carcinoma and Cholangiocarcinoma

B. Daniel Campos and Jean F. Botha

Edited by Kerrin G. Robinson

for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults . Gut 2003 ; 52 ( Suppl III ): iii1 – iii8 . 3 Llovet JM Burroughs A Bruix J . Hepatocellular carcinoma . Lancet 2003 ; 362 : 1907 – 1917 . 4 Blum

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The Changing Treatment Landscape for Metastatic Urothelial Carcinoma

Thomas W. Flaig

. Flaig acknowledged this news and described the systemic treatment options for first- and second-line metastatic urothelial bladder carcinoma ( Figure 1 ). In addition, Dr. Flaig compared the similarities and differences among new immunotherapy options

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Ovarian Clear Cell Carcinoma in Cowden Syndrome

Kevin Yauy, Marion Imbert-Bouteille, Virginie Bubien, Clothilde Lindet-Bourgeois, Gauthier Rathat, Helene Perrochia, Gaëtan MacGrogan, Michel Longy, Didier Bessis, Julie Tinat, Stéphanie Baert-Desurmont, Maud Blanluet, Pierre Vande Perre, Karen Baudry, Pascal Pujol, and Carole Corsini

patient first underwent laparoscopic left adnexectomy and left iliac adenopathy resection surgery. Histologic analysis revealed a 15-cm ovarian clear cell carcinoma (OCCC) with ruptured capsule associated with a 7-cm satellite nodule inside the mesosalpinx

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Surgical Management of Upper Tract Transitional Cell Carcinoma

Alison M. Lake and William W. Roberts

-tract transitional-cell carcinoma . J Endourol 2005 ; 19 : 841 – 848 . 2. Chen GL Bagley DH . Ureteroscopic surgery for upper tract transitional cell carcinoma: complications and management . J Endourol 2001 ; 15 : 399 – 404 . 3. Kerbl K

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Evolving Roles of Histologic Evaluation and Molecular/Genomic Profiling in the Management of Endometrial Cancer

Rajmohan Murali, Deborah F. Delair, Sarah M. Bean, Nadeem R. Abu-Rustum, and Robert A. Soslow

(FIGO) staging system has its limitations, particularly in the setting of corpus-confined carcinoma. Because the current staging scheme applies uniformly to all cases, irrespective of staging adequacy or tumor type, clinical outcomes are highly variable

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Selection of Patients with Hepatocellular Carcinoma for Sorafenib

Ghassan K. Abou-Alfa

Treatment of Unresectable Hepatocellular Carcinoma . Available at: http://www.fda.gov/CDER/Offices/OODP/whatsnew/sorafenib.htm . Accessed February 9, 2009 . 2 Llovet JM Ricci S Mazzaferro V . Sorafenib in advanced hepatocellular carcinoma . N

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Outcomes of Patients With Advanced Gastrointestinal Cancer in Relationship to Opioid Use: Findings From Eight Clinical Trials

Omar Abdel-Rahman, Hatim Karachiwala, and Jacob C. Easaw

( ClinicalTrials.gov identifiers: NCT01124786, NCT00844649), 2 included patients with advanced gastric cancer (NCT00290966, NCT00678535), 1 included patients with advanced hepatocellular carcinoma (HCC; NCT00699374), and 3 included patients with advanced