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Prevention, Diagnosis, and Treatment of Invasive Fungal Infections in Patients with Cancer and Neutropenia

Thomas A. Cumbo and Brahm H. Segal

Elser C . Early detection of chronic disseminated Candida infection in leukemia patients with febrile neutropenia: value of computer-assisted serial ultrasound documentation . Ann Hematol 1998 ; 77 : 41 - 45 . 10 Bjerke JW Meyers JD

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Novel and Emerging Treatment Strategies for Acute Myeloid Leukemia

Presented by: Eunice S. Wang

secondary AML.” One clinical caveat is that rates of myelosuppression and febrile neutropenia with infections were significantly higher for the combination regimen than for azacitidine alone, with many patients requiring close monitoring and frequent

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Optimal First-Line and Maintenance Treatments for Advanced-Stage Nonsquamous Non-Small Cell Lung Cancer

Ryan D. Gentzler and Jyoti D. Patel

significant differences in survival were seen among the 4 regimens. Patients receiving carboplatin and paclitaxel had a lower incidence of grade 3 and 4 nausea, vomiting, and febrile neutropenia. From this point on, carboplatin and paclitaxel became the most

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New Approaches to Endocrine Therapy for Breast Cancer

William J. Gradishar

monitor WBC counts in patients receiving palbociclib and ribociclib, but those who develop neutropenia “generally don't feel the effects” and febrile neutropenia is uncommon, he indicated. “As we move forward,” he added, clinicians can expect “the coming

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Supportive Care in Head and Neck Cancers: Multidisciplinary Management

Presented by: Jimmy J. Caudell, David G. Pfister, and Randal S. Weber

febrile neutropenia. He received empiric antibiotics and antifungal medications, the neutropenia and fever resolved, and he was discharged. He did not require a nasal gastric tube or a PEG tube during treatment, and he went on to receive adjuvant

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Use of Novel Combination Therapies in the Treatment of Advanced HR+/HER2− Breast Cancer

included Table 1. CDK 4/6 Inhibitors neutropenia, anemia, and fatigue. No cases of febrile neutropenia were observed. However, an increased rate of grade 3/4 infections and pulmonary embolism was seen in the palbociclib/letrozole arm (5% vs 0

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Emerging Therapies in the Treatment of Bladder Cancer

Presented by: Arlene O. Siefker-Radtke

govitecan may experience side effects. Neutropenia, including febrile neutropenia, and diarrhea, nausea, and vomiting were among the most frequently reported treatment-related adverse events in the study population. 10 “Patients with bladder cancer, in

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Updates in Clinical Management of Pancreatic Cancer

Presented by: Andrew H. Ko

modified FOLFIRINOX and 35.4% with gemcitabine + nab-paclitaxel. Neutropenia (51.5% vs 60.3%), febrile neutropenia (8.8% vs 3.4%), anorexia (22.8% vs 5.2%), and diarrhea (8.8% vs 1.1%) were among the most frequently reported grade 3 and 4 toxicities. With

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Treatment Updates in Acute Myeloid Leukemia

Presented by: Alexander E. Perl

reduction from 300 to 200 mg. Febrile neutropenia is managed with antibiotics. There were no treatment-related deaths in the QUAZAR study. 6 The NCCN Guidelines do not have data on the use of FLT3 inhibitors posttransplant. Two randomized trials support

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Controversies Regarding Use of Myeloid Growth Factors in Leukemia

Jacqueline N. Poston and Pamela S. Becker

the threshold for recommended use of growth factors in the NCCN Guidelines for MGFs. These guidelines suggest the use of growth factors for regimens that are associated with a high risk of febrile neutropenia (>20%) or an with intermediate risk (10