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NCCN Guidelines Insights: Survivorship, Version 2.2020

Featured Updates to the NCCN Guidelines

Crystal S. Denlinger, Tara Sanft, Javid J. Moslehi, Linda Overholser, Saro Armenian, K. Scott Baker, Gregory Broderick, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Norah Lynn Henry, Christine Hill-Kayser, Melissa Hudson, Nazanin Khakpour, Divya Koura, Allison L. McDonough, Michelle Melisko, Kathi Mooney, Halle C. F. Moore, Natalie Moryl, Tracey O’Connor, Electra D. Paskett, Chirayu Patel, Lindsay Peterson, William Pirl, M. Alma Rodriguez, Kathryn J. Ruddy, Lillie Shockney, Sophia Smith, Karen L. Syrjala, Amye Tevaarwerk, Phyllis Zee, Nicole R. McMillian, and Deborah A. Freedman-Cass

-onset cancer. Guidance is also provided to help promote physical activity, a healthful diet and weight management, and proper immunizations in survivors and to facilitate care coordination to ensure that all needs are addressed. The NCCN Survivorship Panel is

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active lifestyle (At least 30 minutes of moderate intensity activity on most days of the week). Activity recommendations may require modification based on treatment sequelae (i.e., ostomy, neuropathy). ➤ Consume a healthy diet with emphasis on plant

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Microsatellite Instability and KRAS Mutation in Stage IV Colorectal Cancer: Prevalence, Geographic Discrepancies, and Outcomes From the National Cancer Database

Johannes Uhlig, Michael Cecchini, Amar Sheth, Stacey Stein, Jill Lacy, and Hyun S. Kim

, which might be attributable to implementation of colonoscopic screening, use of nonsteroidal anti-inflammatory drugs, and changes in lifestyle and diet. 2 , 3 Concurrently, major advances have been made in CRC treatment, especially regarding the

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The Microbiome Colorectal Cancer Puzzle: Initiator, Propagator, and Avenue for Treatment and Research

Reece J. Knippel and Cynthia L. Sears

, a Western diet, and diabetes have been associated with risk for developing CRC. 1 However, each of the CRC risk factors modifies the gut microbiome, the trillions of microbial species that reside within the colon. Thus, the gut microbiome has become

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Androgen Deprivation Therapy: Minimizing Exposure and Mitigating Side Effects

Miren Gaztañaga and Juanita Crook

. Unfortunately, lifestyle recommendations, such as smoking cessation, adopting a healthy diet, and undertaking regular exercise, are offered infrequently. Strategies for symptom management help patients cope and reduce distress, 45 although ongoing support may

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Ten Years of Progress in Colon Cancer Therapy

Paul F. Engstrom

depression. Most importantly, the guidelines emphasized exercise and appropriate diet. Studies in patients who survive after cancer treatment showed that those who participate in physical exercise show improved survival over those who were sedentary and

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Metastatic Colorectal Cancer: Lessons Learned, Future Possibilities

Alan P. Venook

. It is now known that exercise, aspirin, and a non-Western diet are associated with a decreased risk of disease recurrence; aspirin is associated with a reduced risk of death; and sweetened beverages are associated with an increased risk of recurrence

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Crescendos and Decrescendos: Gastric and Esophageal Cancers

Jaffer A. Ajani

among white americans by sex, stage, and age . J Natl Cancer Inst 2008 ; 100 : 1184 – 1187 . 3 Brown LM Swanson CA Gridley G . Adenocarcinoma of the esophagus: role of obesity and diet . J Natl Cancer Inst 1995 ; 87 : 104 – 109

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Modification and Implementation of NCCN Guidelines™ on Colon Cancer in the Middle East and North Africa Region

Fikri İçli, Hakan Akbulut, Shouki Bazarbashi, Mehmet Ayhan Kuzu, Mohandas K. Mallath, Kakil Ibrahim Rasul, Scott Strong, Aamir Ali Syed, Faruk Zorlu, and Paul F. Engstrom

intake in the diet or issues related to food hygiene. The committee proposed a prospective trial be conducted to find the optimal dose for the patients in the region. Proposal 3 Stereotactic radiation for liver metastasis could be an alternative

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New NCCN Guidelines: Recognition and Management of Immunotherapy-Related Toxicity

John A. Thompson

be initiated. If DKA is not present, immunotherapy may be continued and blood glucose levels should be monitored with each dose. Patients should also be advised to modify their diet and lifestyle accordingly. Endocrine consultation should be