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Edward E. Partridge, Nadeem Abu-Rustum, Anna Giuliano, Stewart Massad, Joan McClure, Mary Dwyer, and Miranda Hughes

guidelines from the American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology, the NCCN Guidelines for Cervical Cancer Screening were discontinued. 1 , 17 Development of the screening

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Christopher K. Bichakjian, Thomas Olencki, Murad Alam, James S. Andersen, Daniel Berg, Glen M. Bowen, Richard T. Cheney, Gregory A. Daniels, L. Frank Glass, Roy C. Grekin, Kenneth Grossman, Alan L. Ho, Karl D. Lewis, Daniel D. Lydiatt, William H. Morrison, Kishwer S. Nehal, Kelly C. Nelson, Paul Nghiem, Clifford S. Perlis, Ashok R. Shaha, Wade L. Thorstad, Malika Tuli, Marshall M. Urist, Timothy S. Wang, Andrew E. Werchniak, Sandra L. Wong, John A. Zic, Karin G. Hoffmann, Nicole R. McMillian, and Maria Ho

.2014 Version 1.2014, 12-20-13 ©2014 National Comprehensive Cancer Network, Inc. All rights reserved. The NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN®. Pathology Report The

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Gerald A. Soff

data showing greater efficacy with DOACs compared with LMWHs, but cautioned about an increased risk of bleeding in patients with genitourinary tract pathology or nephrostomy tubes, or in patients with active gastrointestinal mucosal abnormalities such

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Boyu Hu, Jay L. Patel, Randa Tao, Richard B. Cannon, Marcus Monroe, and Gaurav Goyal

level 2 right-sided cervical lymph node was performed. Pathology of the excised lymph node showed diffuse effacement of architecture by proliferation of atypical histiocytes with ample cytoplasm, oval to spindle nuclei with occasional grooves, and

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NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021

Featured Updates to the NCCN Guidelines

Susan M. Swetter, John A. Thompson, Mark R. Albertini, Christopher A. Barker, Joel Baumgartner, Genevieve Boland, Bartosz Chmielowski, Dominick DiMaio, Alison Durham, Ryan C. Fields, Martin D. Fleming, Anjela Galan, Brian Gastman, Kenneth Grossmann, Samantha Guild, Ashley Holder, Douglas Johnson, Richard W. Joseph, Giorgos Karakousis, Kari Kendra, Julie R. Lange, Ryan Lanning, Kim Margolin, Anthony J. Olszanski, Patrick A. Ott, Merrick I. Ross, April K. Salama, Rohit Sharma, Joseph Skitzki, Jeffrey Sosman, Evan Wuthrick, Nicole R. McMillian, and Anita M. Engh

of regional or distant metastatic disease if present. For patients with resected stage III–IV melanoma, adjuvant systemic immune and targeted therapies are an important means of improving disease-free survival. Revisions to Pathology

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Thomas B. Nealis, Kay Washington, and Rajesh N. Keswani

dysplastic Barrett's. Because esophagectomy may be associated with significant morbidity, endoscopic therapies for premalignant Barrett's esophagus and early EAC have been developed and studied. Pathology of Barrett's Esophagus With the emergence of new

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Matthew H. Kulke, Al B. Benson III, Emily Bergsland, Jordan D. Berlin, Lawrence S. Blaszkowsky, Michael A. Choti, Orlo H. Clark, Gerard M. Doherty, James Eason, Lyska Emerson, Paul F. Engstrom, Whitney S. Goldner, Martin J. Heslin, Fouad Kandeel, Pamela L. Kunz, Boris W. Kuvshinoff II, Jeffrey F. Moley, Venu G. Pillarisetty, Leonard Saltz, David E. Schteingart, Manisha H. Shah, Stephen Shibata, Jonathan R. Strosberg, Jean-Nicolas Vauthey, Rebekah White, James C. Yao, Deborah A. Freedman-Cass, and Mary A. Dwyer

only 19.5%. 22 In addition to information on histologic classification and stage, the margin status (positive or negative) and the presence of vascular or perineural invasion should be indicated on the pathology report, because they may also have

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Christopher K. Bichakjian, Thomas Olencki, Murad Alam, James S. Andersen, Daniel Berg, Glen M. Bowen, Richard T. Cheney, Gregory A. Daniels, L. Frank Glass, Roy C. Grekin, Kenneth Grossman, Alan L. Ho, Karl D. Lewis, Daniel D. Lydiatt, William H. Morrison, Kishwer S. Nehal, Kelly C. Nelson, Paul Nghiem, Clifford S. Perlis, Ashok R. Shaha, Wade L. Thorstad, Malika Tuli, Marshall M. Urist, Timothy S. Wang, Andrew E. Werchniak, Sandra L. Wong, John A. Zic, Nicole McMillian, Karin Hoffman, and Maria Ho

during the initial development of this guideline. The latest full guideline, including a complete list of updates, is available on the NCCN Web site at NCCN.org . These NCCN Guidelines Insights highlight the addition of the “Principles of Pathology

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Julie E.M. Swillens, Quirinus J.M. Voorham, Iris D. Nagtegaal, and Rosella P.M.G. Hermens

information is mainly provided by pathologists and radiologists. 4 Research has shown that inadequate pathology and radiology information can cause MDT decision failures. 5 , 6 Traditionally, diagnostic findings were reported with narrative reporting (NR

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Julie E.M. Swillens, Quirinus J.M. Voorham, Iris D. Nagtegaal, and Rosella P.M.G. Hermens

information is mainly provided by pathologists and radiologists. 4 Research has shown that inadequate pathology and radiology information can cause MDT decision failures. 5 , 6 Traditionally, diagnostic findings were reported with narrative reporting (NR