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Cancer-Related Fatigue Clinical Practice Guidelines in Oncology

The problem of cancer-related fatigue, which affects 70% to 100% of cancer patients, has been exacerbated by the increased use of fatigue-inducing multimodal treatments and dose-dense, dose-intense protocols. In patients with metastatic disease, the prevalence of cancer-related fatigue exceeds 75%, and cancer survivors report that fatigue is a disruptive symptom months or even years after treatment ends. To address the significant problem of cancer-related fatigue, the NCCN convened a panel of experts in the field of fatigue. The Cancer-Related Fatigue Clinical Practice Guidelines synthesize the available research and clinical experience in this field and provide recommendations for patient care.

For the most recent version of the guidelines, please visit NCCN.org

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 1 (2003): Issue 3 (Jul 2003)

Jul 2003
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Complications of Multiple Myeloma Therapy, Part 1: Risk Reduction and Management of Peripheral Neuropathy and Asthenia

Paul G. Richardson, Jacob P. Laubach, Robert L. Schlossman, Constantine Mitsiades, and Kenneth Anderson

Peripheral neuropathy (PN) and asthenia (fatigue) are among the most commonly seen complications in patients undergoing multiple myeloma (MM) therapy. These potentially debilitating adverse effects are frequently dose limiting, and they may

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 8 (2010): Issue Suppl_1 (Feb 2010): Addressing Challenges in Multiple Myeloma Management in an Era of New Therapeutics

Feb 2010
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Letter to the Editor: Panax Ginseng for Cancer-Related Fatigue

Andrea Angelo Martoni, Luigi Cavanna, and Gianpiero Porzio

Re: Sriram Yennurajalingam, Nizar M. Tannir, Janet L. Williams, et al. A Double-Blind, Randomized, Placebo-Controlled Trial of Panax Ginseng for Cancer-Related Fatigue in Patients With Advanced Cancer. J Natl Compr Canc Netw 2017

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 16 (2018): Issue 4 (Apr 2018)

Apr 2018
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Dissemination and Implementation of Guidelines for Cancer-Related Fatigue

Ann M. Berger and Kathi Mooney

Evidence-based recommendations for cancer-related fatigue (CRF) have been disseminated recently by all major cancer organizations (NCCN, Oncology Nursing Society [ONS], Canadian Partnership Against Cancer/Canadian Association of Psychosocial

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 14 (2016): Issue 11 (Nov 2016)

Nov 2016
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Cancer Patient Survival and Erythropoietin

John A. Glaspy

anemic cancer patients when referenced to the general population . J Clin Oncol 2003 ; 21 : 366 – 373 . 2 Cella D Kallich J McDermott A Xu X . The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 3 (2005): Issue 6 (Nov 2005)

Nov 2005
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Erythropoiesis-Stimulating Agents in Oncology

John A. Glaspy

X . The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials . Ann Oncol 2004 ; 15 : 979 – 986 . 6. Berndt E Kallich J McDermott A . Reductions in

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 6 (2008): Issue 6 (Jul 2008)

Jul 2008
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Quality of Life Is Associated With Survival in Patients With Gastric Cancer: Results From the Randomized CRITICS Trial

Romy M. van Amelsfoort, Iris Walraven, Jacobien Kieffer, Edwin P.M. Jansen, Annemieke Cats, Nicole C.T. van Grieken, Elma Meershoek-Klein Kranenbarg, Hein Putter, Johanna W. van Sandick, Karolina Sikorska, Cornelis J.H. van de Velde, Neil K. Aaronson, Marcel Verheij, and on behalf of the CRITICS Investigators

functioning, role functioning, cognitive functioning, emotional functioning, and social functioning), 3 multi-item symptom scales (fatigue, nausea and vomiting, and pain), 6 single-item symptom scales (dyspnea, insomnia, appetite loss, constipation, diarrhea

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 20 (2022): Issue 3 (Mar 2022)

Mar 2022
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Relationship Between Quality of Life and Survival in Patients With Pancreatic and Periampullary Cancer: A Multicenter Cohort Analysis

Tara M. Mackay, Anouk E.J. Latenstein, Mirjam A.G. Sprangers, Lydia G. van der Geest, Geert-Jan Creemers, Susan van Dieren, Jan-Willem B. de Groot, Bas Groot Koerkamp, Ignace H. de Hingh, Marjolein Y.V. Homs, Evelien J.M. de Jong, I. Quintus Molenaar, Gijs A. Patijn, Lonneke V. van de Poll-Franse, Hjalmar C. van Santvoort, Judith de Vos-Geelen, Johanna W. Wilmink, Casper H. van Eijck, Marc G. Besselink, Hanneke W.M. van Laarhoven, and for the Dutch Pancreatic Cancer Group

cancer-specific EORTC QLQ-C30 questionnaire encompasses global health status, 5 functioning scales (ie, physical, role, emotional, cognitive, and social functioning) and 8 symptom scales/items (ie, fatigue, nausea and vomiting, pain, dyspnea, insomnia

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 18 (2020): Issue 10 (Oct 2020)

01 Oct 2020
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Survivorship: Sleep Disorders, Version 1.2014

Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Wendy Demark-Wahnefried, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Grace H. Ku, Elizabeth Kvale, Terry S. Langbaum, Kristin Leonardi-Warren, Mary S. McCabe, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Javid J. Moslehi, Tracey O’Connor, Linda Overholser, Electra D. Paskett, Muhammad Raza, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole McMillian, and Deborah Freedman-Cass

parasomnias. 1 Sleep disorders affect 30% to 50% of patients with cancer and survivors, often in combination with fatigue, anxiety, or depression. 1 - 10 Improvements in sleep lead to improvements in fatigue, mood, and quality of life. 11 Most clinicians

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 12 (2014): Issue 5 (May 2014)

May 2014
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CLO19-059: A Systematic Review and Meta- Analysis of Randomized Controlled Trials to Evaluate the Risk of Health-Related Quality of Life Events in Patients With Hormone Receptor-Positive HER2-Negative Metastatic Breast Cancer Treated With CDK 4/6 Inhibitors

Rachana Yendala, Kyaw Thein, Sriman Swarup, Anita Sultan, Somedeb Ball, Miguel Quirch, Myo H. Zaw, Yin M. Myat, and Catherine Jones

Background: Pain, fatigue, hot flushes, and rash significantly contribute to quality of life in breast cancer patients undergoing chemotherapy. Hormone receptor-positive breast cancer is a common entity among women worldwide. In cancer cells, CDK4

Cover Journal of the National Comprehensive Cancer Network

In Journal of the National Comprehensive Cancer Network Volume 17 (2019): Issue 3.5 (Mar 2019): Abstracts from the NCCN 2019 Annual Conference

08 Mar 2019