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Germline and Somatic Mutations in Prostate Cancer for the Clinician

Heather H. Cheng, Alexandra O. Sokolova, Edward M. Schaeffer, Eric J. Small, and Celestia S. Higano

-adjusted PSA ranges 3, 38 , 39 may consider prostate biopsy, which may be MRI/ultrasound fusion−guided. Figure 2. Recommendations for prostate cancer early detection in carriers of high-risk mutations. Abbreviations: DRE, digital rectal examination; mpMRI

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Guidelines for Improving Breast Health Care in Limited Resource Countries: The Breast Health Global Initiative

Benjamin O. Anderson and Robert W. Carlson

; 52 : 277 – 300 . 16. Smith RA Cokkinides V Eyre HJ . American Cancer Society Guidelines for the early detection of cancer, 2005 . CA Cancer J Clin 2005 ; 55 : 31 – 44 . quiz 55–56 . 17. NCCN Breast Cancer Screening and

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EPR22-119: Cost-Effectiveness of Multi-Cancer Early Detection (MCED) Test in Subgroups With Smoking History or Obesity

Ali Tafazzoli, Scott D. Ramsey, Alissa Shaul, Weicheng Ye, Ameya Chavan, Karen C. Chung, Anuraag R. Kansal, and A. Mark Fendrick

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High Risk Human Papillomavirus Testing: Guidelines for Use in Screening, Triage, and Follow-up for the Prevention and Early Detection of Cervical Cancer

Kathleen N. Moore and Joan L. Walker

The changes in cervical cytology characterization agreed on by the Bethesda committee meeting in 2001 created a category of atypical findings that has caused some management confusion. By description, the characterization of cervical cytology as only atypical implies a less worrisome prognosis. However, more than 40% of high-grade (CIN II or III or cancer) will be discovered within this category. The development and Food and Drug Administration approval of the Hybrid Capture 2 (HC-2; Digene Corporation, Gaithersburg, MD) for detecting high-risk human papillomavirus (HR-HPV) subtypes and the subsequent level I evidence supporting use of this test in the triage of women with atypical cytology has revolutionized the management of this cytology. With this success has come numerous additional uses for HR-HPV testing in the treatment and follow-up of women with a variety of cytologic abnormalities. This article reviews the literature on uses of HR-HPV testing in this population, with reference to currently accepted guidelines.

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The Case for Tailored Prostate Cancer Screening: An NCCN Perspective

Michelle L. McDonald and J. Kellogg Parsons

part to lead time bias after earlier detection through widespread use of prostate-specific antigen (PSA) testing, this trend has also largely been attributed to the treatment of screen-detected tumors. 2 – 4 Randomized trials have since confirmed the

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Screening for Lung Cancer: An Expert Review

Presented by: Ella A. Kazerooni, Jacob Sands, and Douglas E. Wood

mortality and a 6.7% ( P =.02) reduction in all-cause mortality, primarily due to the early detection of lung cancer. The US Preventive Services Task Force (USPSTF) and the Centers for Medicare & Medicaid Services (CMS) both approved the use of lung cancer

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Use of NCCN Guidelines, Other Guidelines, and Biomarkers for Colorectal Cancer Screening

Christina D. Williams, William M. Grady, and Leah L. Zullig

). Because of its ability to detect and remove precancerous polyps, colonoscopy is a useful and unique tool not only in the early detection of cancer but also in cancer prevention. 6 A number of organizations have established recommendations and clinical

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Prostate Biopsy Strategies: Current State of the Art

Badar M. Mian

most out of six systematic sextant biopsies . Urology 1995 ; 45 : 2 – 12 . 4 Catalona WJ Richie JP Ahmann FR . Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results

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CLO19-060: Blood Exosomal Long RNA Profiling Identifies Diagnostic and Prognostic Markers in Pancreatic Ductal Adenocarcinoma

Shulin Yu, Peng Wang, and Zhen Chen

in cancer remains unknown. The study aimed to explore the exoLR landscape of human blood exosomes and evaluate the feasibility of developing a diagnostic or prognostic signature for early detection and prognostic prediction of pancreatic ductal

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Screening Mammography for Average-Risk Women: The Controversy and NCCN's Position

Mark A. Helvie and Therese B. Bevers

%, which has been attributed to advances in screening, treatment, and early detection. 6 An even greater 49% mortality decline is estimated when adjustments are made for existing background mortality trends. 7 Invasive breast cancer incidence in the