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Point: Treating Stage II Colon Cancer: The Quest for Personalized Adjuvant Care

Maxwell T. Vergo and Al B. Benson III

risk reduction), which was nonsignificant. Both studies were underpowered to detect an OS benefit, and therefore definitive conclusions about 5-FU–based adjuvant therapy in stage II disease are difficult to draw from these studies. In contrast, 2

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HSR22-180: Real-World Treatment Patterns and Outcomes of Targeted Therapy and Immunotherapy in BRAF+ Cutaneous Melanoma Patients Treated in the Adjuvant Setting

Sanjay Chandrasekaran, You-Li Ling, Jackson Tang, Deborah Norton, and Rohan Shah

: Recurrence-free survival with 1L DT or IO as adjuvant therapy for BRAF + melanoma

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Importance of Node Dissection in Relation to Neoadjuvant and Adjuvant Therapy

William C. Huang and Bernard H. Bochner

Since the advent of effective chemotherapeutic regimens for treating transitional cell carcinoma, multimodal therapy has become part of the contemporary management of patients with muscle-invasive bladder cancer. However, radical cystectomy with pelvic lymphadenectomy remains the cornerstone of treatment for patients with localized and regionally advanced muscle-invasive disease. The effectiveness of chemotherapy models in bladder cancer can depend greatly on the quality of surgery. Unfortunately, without sufficient level I data, the boundaries of lymphadenectomy and the diagnostic and therapeutic ramifications of variations in the pelvic lymph node dissection remain undetermined. This article examines the role of pelvic lymph node dissection during perioperative chemotherapy and discusses the current challenges in establishing standards for lymphadenectomy in patients undergoing treatment for muscle-invasive bladder cancer.

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NCCN Guidelines and Quality Cancer Care: Where Have We Come From, and Where Should We Be Going?

Daniel G. Coit

guidelines for physicians treating patients with melanoma of all stages. We were to develop recommendations for the diagnosis, workup, initial treatment including adjuvant therapy, follow-up, and management of recurrent disease. Over the ensuing 2 decades

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The Evolving Role of Neoadjuvant Therapy for Operable Breast Cancer

Laura M. Spring, Yael Bar, and Steven J. Isakoff

evolving neoadjuvant therapy trial designs. (A) Traditional neoadjuvant trials randomize all therapy preoperatively, followed by standard subtype-specific adjuvant therapy regardless of pathologic response. (B) Postneoadjuvant/residual disease trials

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Management of Patients With Advanced Melanoma

Presented by: Genevieve Boland

adjuvant therapy trials of immune checkpoint inhibitors (ICIs) in stage III–IV melanoma and their outcomes. Figure 1. Adjuvant therapy in stage III–IV melanoma. Abbreviations: D/T, dabrafenib + trametinib; DMFS, distant metastasis–free survival; HR

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CLO21-021: Impact on Survival of the Number of Lymph Nodes Resected in Patients With Esophageal Cancer Following Neo-Adjuvant Therapy

Jordan McDonald, Anupam Rishi, Sabrina Saeed, Rutika Mehta, David Pointer, Jessica Frakes, Sarah Hoffe, Jacques Fontaine, and Jose Pimiento

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Association Between Frailty and Time Alive and At Home After Cancer Surgery Among Older Adults: A Population-Based Analysis

Julie Hallet, Bourke Tillman, Jesse Zuckerman, Matthew P. Guttman, Tyler Chesney, Alyson L. Mahar, Wing C. Chan, Natalie Coburn, Barbara Haas, and members of the Recovery after Surgical Therapy for Older adults Research–Cancer (RESTORE-Cancer) Group

). Adjusted for age (categorical), sex, rural residence, comorbidity burden, material deprivation, immigration status, stage at diagnosis, year of surgery, neoadjuvant therapy, adjuvant therapy, intensity of surgical procedure, and cancer type. Subgroup

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Melanoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology

Daniel G. Coit, John A. Thompson, Alain Algazi, Robert Andtbacka, Christopher K. Bichakjian, William E. Carson III, Gregory A. Daniels, Dominick DiMaio, Marc Ernstoff, Ryan C. Fields, Martin D. Fleming, Rene Gonzalez, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr, Richard W. Joseph, Julie R. Lange, Mary C. Martini, Miguel A. Materin, Anthony J. Olszanski, Merrick I. Ross, April K. Salama, Joseph Skitzki, Jeff Sosman, Susan M. Swetter, Kenneth K. Tanabe, Javier F. Torres-Roca, Vijay Trisal, Marshall M. Urist, Nicole McMillian, and Anita Engh

statistically significant improvement in relapse-free survival ( Table 1 ). Intermediate-dose IFN, defined as 5 to 10 MU per day subcutaneously for 3 to 5 days per week, has also been compared with observation as adjuvant therapy for resected, high-risk melanoma

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Decision-Making For Patients With Resectable Breast Cancer: Individualized Decisions For and By Patients and Their Physicians

Charles L. Loprinzi and Peter M. Ravdin

. 5 Ravdin PM Siminoff LA Davis GJ . Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer . J Clin Oncol 2001 ; 19 : 980 - 991 . 6 Loprinzi CL Thome SD . Understanding the utility