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children treated in the CCG-945 study. No evidence was seen that temozolomide given during radiotherapy and as an adjuvant therapy resulted in improved event-free survival compared with that found in CCG-945. 4 In addition, temozolomide failed to improve

Regan MM Maiorano E . Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98 . J

support (and your adopted pathway for any given instance) when it really matters—at the point of decision—can be expensive. Agreement on common definitions can also be difficult, even for elements as simple as what constitutes third-line or adjuvant

. Describe the ideal treatment with adjuvant chemotherapy for patients with estrogen receptor (ER)-positive HER2-negative lymph node-negative breast cancer. Case Report A 67-year-old otherwise healthy postmenopausal woman presented for adjuvant

with cervical cancer either as 1) definitive therapy for those with locally advanced disease or for those who are poor surgical candidates, or 2) adjuvant therapy after radical hysterectomy for those who have one or more pathologic risk factors (eg

.” Furthermore, “vismodegib may be considered for neoadjuvant therapy, but there is no role for it as adjuvant therapy at this time,” concluded Dr. Olencki. New Agents Are Needed for MCC Considered to be one of the most lethal skin cancers, MCC is an

surgery to adjuvant therapies, as defined by the NCCN Oncology Outcomes Database. 21 , 22 Time to treatment may be an important measure of the performance of a cancer program. Delays in treatment, and disparities in delay have clearly been described in

risks of postsurgical complications. 5 “How we thought about adjuvant therapy has changed,” said Dr. Gradishar. “Physicians used to look at the number of nodes as a determinant of whether a patient was a candidate for chemotherapy, as well as what kind

, they should not be given outside of a clinical trial, Dr. Choueiri noted. Numerous biomarkers are under investigation, but none should be clinically applied at this time, he said. Adjuvant Therapy and Other Histologies In contrast to metastatic

with cytogenetics may be useful before initiating imatinib therapy. Radiation has occasionally been used as a primary therapeutic modality for DFSP, 35 but it is more commonly used as adjuvant therapy after surgery. 36 – 38 Postoperative radiation