children treated in the CCG-945 study. No evidence was seen that temozolomide given during radiotherapy and as an adjuvant therapy resulted in improved event-free survival compared with that found in CCG-945. 4 In addition, temozolomide failed to improve
Search Results
High-Grade Glioma/Glioblastoma Multiforme: Is There a Role for Photodynamic Therapy?
Harry T. Whelan
Pazopanib Sensitivity in a Patient With Breast Cancer and FGFR1 Amplification
Fiona Tsui-Fen Cheng, Fu Ou-Yang, Nina Lapke, Kai-Che Tung, Yen-Kung Chen, Yuh-Yu Chou, and Shu-Jen Chen
Regan MM Maiorano E . Prognostic and predictive value of centrally reviewed expression of estrogen and progesterone receptors in a randomized trial comparing letrozole and tamoxifen adjuvant therapy for postmenopausal early breast cancer: BIG 1-98 . J
Defining Cancer Care Quality or Delivering Quality Cancer Care?
Matt Brow, J. Russell Hoverman, Debra Patt, Bill Herman, Diana Verrilli, Jody Garey, and Roy Beveridge
support (and your adopted pathway for any given instance) when it really matters—at the point of decision—can be expensive. Agreement on common definitions can also be difficult, even for elements as simple as what constitutes third-line or adjuvant
Adjuvant Chemotherapy Decisions in Clinical Practice for Early-Stage Node-Negative, Estrogen Receptor-Positive, HER2-Negative Breast Cancer: Challenges and Considerations
Gayathri Nagaraj and Cynthia X. Ma
. Describe the ideal treatment with adjuvant chemotherapy for patients with estrogen receptor (ER)-positive HER2-negative lymph node-negative breast cancer. Case Report A 67-year-old otherwise healthy postmenopausal woman presented for adjuvant
Cervical Cancer
Wui-Jin Koh, Benjamin E. Greer, Nadeem R. Abu-Rustum, Sachin M. Apte, Susana M. Campos, John Chan, Kathleen R. Cho, David Cohn, Marta Ann Crispens, Nefertiti DuPont, Patricia J. Eifel, David K. Gaffney, Robert L. Giuntoli II, Ernest Han, Warner K. Huh, John R. Lurain III, Lainie Martin, Mark A. Morgan, David Mutch, Steven W. Remmenga, R. Kevin Reynolds, William Small Jr, Nelson Teng, Todd Tillmanns, Fidel A. Valea, Nicole R. McMillian, and Miranda Hughes
with cervical cancer either as 1) definitive therapy for those with locally advanced disease or for those who are poor surgical candidates, or 2) adjuvant therapy after radical hysterectomy for those who have one or more pathologic risk factors (eg
Optimal Treatment of Unresectable Nonmelanoma Skin Cancers
Thomas Olencki
.” Furthermore, “vismodegib may be considered for neoadjuvant therapy, but there is no role for it as adjuvant therapy at this time,” concluded Dr. Olencki. New Agents Are Needed for MCC Considered to be one of the most lethal skin cancers, MCC is an
The NCCN Guidelines Program and Opportunities for Quality Improvement
Stephen B. Edge
surgery to adjuvant therapies, as defined by the NCCN Oncology Outcomes Database. 21 , 22 Time to treatment may be an important measure of the performance of a cancer program. Delays in treatment, and disparities in delay have clearly been described in
NCCN News
risks of postsurgical complications. 5 “How we thought about adjuvant therapy has changed,” said Dr. Gradishar. “Physicians used to look at the number of nodes as a determinant of whether a patient was a candidate for chemotherapy, as well as what kind
Clinical Treatment Decisions for Advanced Renal Cell Cancer
Toni K. Choueiri
, they should not be given outside of a clinical trial, Dr. Choueiri noted. Numerous biomarkers are under investigation, but none should be clinically applied at this time, he said. Adjuvant Therapy and Other Histologies In contrast to metastatic
Dermatofibrosarcoma Protuberans
Stanley J. Miller, Murad Alam, James S. Andersen, Daniel Berg, Christopher K. Bichakjian, Glen M. Bowen, Richard T. Cheney, L. Frank Glass, Roy C. Grekin, Alan L. Ho, Anne Kessinger, Nanette Liegeois, Daniel D. Lydiatt, Jeff Michalski, William H. Morrison, Kishwer S. Nehal, Kelly C. Nelson, Paul Nghiem, Thomas Olencki, Clifford S. Perlis, Ashok R. Shaha, Malika Tuli, Marshall M. Urist, Linda C. Wang, and John A. Zic
with cytogenetics may be useful before initiating imatinib therapy. Radiation has occasionally been used as a primary therapeutic modality for DFSP, 35 but it is more commonly used as adjuvant therapy after surgery. 36 – 38 Postoperative radiation