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Mutation Testing and Adjuvant Systemic Therapy in Cutaneous Melanoma

Anthony J. Olszanski

exciting results in the adjuvant setting: relapse-free survival was significantly increased in patients with fully resected stage III disease (based on AJCC 7th edition) with a BRAF V600E/K mutation. 7 Adjuvant Immunotherapy The addition of immunotherapy

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Preoperative and Postoperative Approaches to Gastroesophageal Cancer: What is All the Fuss About

Lucy X. Ma, Elan D. Panov, Michael J. Allen, Gail E. Darling, Jonathan C. Yeung, Carol J. Swallow, Savtaj S. Brar, Rebecca K. Wong, Patrick Veit-Haibach, Sangeetha N. Kalimuthu, Eric X. Chen, Raymond W. Jang, and Elena Elimova

became the standard of care for resectable esophageal cancer in North America. Adjuvant Immunotherapy Although the use of multimodality treatment has achieved incremental progress in improving outcomes in gastroesophageal cancers, up to half of

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Management of Patients With Resectable and Metastatic Non–Small Cell Lung Cancer

Presented by: Jane Yanagawa and Gregory J. Riely

for adjuvant immunotherapy after lung resection for early-stage NSCLC. In the IMpower010 trial, 1,005 patients with completely resected stage IB–IIIA disease after adjuvant chemotherapy were randomly assigned to atezolizumab (up to 16 cycles or 1 year

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The Evolving Role of Neoadjuvant Therapy for Operable Breast Cancer

Laura M. Spring, Yael Bar, and Steven J. Isakoff

alone in a post hoc biomarkers analysis of the NeoTRIPaPDL1 study. 36 Nevertheless, identifying new predictive biomarkers for response to neoadjuvant immunotherapy remains an urgent need. Another key open question is whether adjuvant immunotherapy is

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Immunotherapy-Based Neoadjuvant Treatment of Advanced Microsatellite Instability–High Gastric Cancer: A Case Series

Louisa Liu, Yanghee Woo, Massimo D’Apuzzo, Laleh Melstrom, Mustafa Raoof, Yu Liang, Michelle Afkhami, Stanley R. Hamilton, and Joseph Chao

of neoadjuvant compared to adjuvant immunotherapy to eradicate metastatic disease . Cancer Discov 2016 ; 6 : 1382 – 1399 . 27663893 10.1158/2159-8290.CD-16-0577 15. O’Donnell JS , Hoefsmit EP , Smyth MJ , The promise of

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On the Verge: Immunotherapy for Colorectal Carcinoma

David Y. Oh, Alan P. Venook, and Lawrence Fong

adjuvant immunotherapy with BCG and neuraminidase-treated autologous tumour cells in large bowel cancer . J Surg Oncol 1989 ; 40 : 34 – 37 . 18. Hoover HC Jr Brandhorst JS Peters LC . Adjuvant active specific immunotherapy for human

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Regional Radiation Therapy Impacts Outcome for Node-Positive Cutaneous Melanoma

Tobin Strom, Javier F. Torres-Roca, Akash Parekh, Arash O. Naghavi, Jimmy J. Caudell, Daniel E. Oliver, Jane L. Messina, Nikhil I. Khushalani, Jonathan S. Zager, Amod Sarnaik, James J. Mulé, Andy M. Trotti, Steven A. Eschrich, Vernon K. Sondak, and Louis B. Harrison

.277–2.399; P <.001), nodal size >2 cm (HR, 1.405; 95% CI, 1.045–1.889; P =.02), and adjuvant immunotherapy (to be reported separately). OS by RSI Status To assess whether a gene signature of radiosensitivity could help identify which patients might