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James E. Montie, Peter E. Clark, Mario A. Eisenberger, Rizk El-Galley, Richard E. Greenberg, Harry W. Herr, Gary R. Hudes, Deborah A. Kuban, Timothy M. Kuzel, Paul H. Lange, Subodh M. Lele, Jeffrey Michalski, Anthony Patterson, Kamal S. Pohar, Jerome P. Richie, Wade J. Sexton, William U. Shipley, Eric J. Small, Donald L. Trump, Phillip J. Walther, and Timothy G. Wilson

the express written permission of the NCCN © 2009. Disclosures for the NCCN Bladder Cancer Guidelines Panel At the beginning of each NCCN guidelines panel meeting, panel members disclosed any financial support they have received from industry

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Elizabeth R. Kessler, Janet B. Kukreja, Christopher L. Geiger, and Stacy M. Fischer

Bladder cancer is primarily seen among elderly individuals, with a median age at diagnosis of 73 years and most patients aged 65 to 85 years. It is the fourth leading cause of cancer-related death among men aged >80 years. 1 Thus, clinical care

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Matthew D. Galsky, Harry W. Herr, and Dean F. Bajorin

treatment of invasive bladder cancer: Long-term results in 1,054 patients . J Clin Oncol 2001 ; 19 : 666 – 675 . 2 Vieweg J Gschwend JE Herr HW . Pelvic lymph node dissection can be curative in patients with node positive bladder cancer . J

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John B. Eifler, Daniel A. Barocas, and Matthew J. Resnick

A diagnosis of bladder cancer encompasses a wide variety of clinical entities, characterized by a range of genotypes and phenotypes, each with a unique susceptibility to various treatment modalities, rate of disease progression, and prognosis. The

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Thomas W. Flaig

“After decades without new bladder cancer treatments, in the past 2 years, and even more so in the past 6 to 9 months, approvals and clinical integration of new drugs have accelerated. We're finally getting traction against the disease,” according

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The UNMC Eppley Cancer Center at The Nebraska Medical Center

An estimated 61,420 new cases of urinary bladder cancer will be diagnosed in the United States in 2006, making it the fourth most common cancer in men and the ninth most common neoplasm in women. Because the median age of diagnosis is 65 years, medical comorbidities are a frequent consideration. The clinical spectrum of bladder cancer can be divided into 3 categories: noninvasive tumors, invasive lesions, and metastatic lesions. These categories differ in prognosis, management, and therapeutic goals, and these guidelines discuss management strategies to achieve the best possible outcomes.

For the most recent version of the guidelines, please visit

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William C. Huang and Bernard H. Bochner

dissection, and bilateral uretero-enterostomy . J Urol 1950 ; 63 : 242 – 260 . 4. Mills RD Turner WH Fleischmann A . Pelvic lymph node metastases from bladder cancer: outcome in 83 patients after radical cystectomy and pelvic lymphadenectomy

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Harry W. Herr

Non–muscle-invasive bladder cancers (NMIBCs) account for 75% of new cases. These include non–minimally invasive (Ta) and minimally invasive (T1) papillary tumors and flat carcinoma in situ (CIS). Papillary bladder tumors are classified as low

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Thomas W. Flaig, Philippe E. Spiess, Neeraj Agarwal, Rick Bangs, Stephen A. Boorjian, Mark K. Buyyounouski, Sam Chang, Tracy M. Downs, Jason A. Efstathiou, Terence Friedlander, Richard E. Greenberg, Khurshid A. Guru, Thomas Guzzo, Harry W. Herr, Jean Hoffman-Censits, Christopher Hoimes, Brant A. Inman, Masahito Jimbo, A. Karim Kader, Subodh M. Lele, Jeff Michalski, Jeffrey S. Montgomery, Lakshminarayanan Nandagopal, Lance C. Pagliaro, Sumanta K. Pal, Anthony Patterson, Elizabeth R. Plimack, Kamal S. Pohar, Mark A. Preston, Wade J. Sexton, Arlene O. Siefker-Radtke, Jonathan Tward, Jonathan L. Wright, Lisa A. Gurski, and Alyse Johnson-Chilla

Overview An estimated 80,470 new cases of urinary bladder cancer (61,700 men and 18,770 women) will be diagnosed in the United States in 2019 with approximately 17,670 deaths (12,870 men and 4,800 women) occurring during this same period. 1 Bladder

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S. Machele Donat

Cancer J Clin 2008 : 58 : 71 – 96 . 2 Stein JP Lieskovsky G Cote R . Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients . J Clin Oncol 2001 ; 19 : 666 – 675 . 3 Dalbagni G Genega