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NCCN News

imaging specialists, and pulmonologists. “Radiation is recommended as an adjuvant therapy to improve local control after surgery, and it is also an effective palliative treatment for relief of chest pain that is often associated with mesothelioma,” said

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Renaming Ductal Carcinoma in Situ: Would Removing “Carcinoma” Reduce Overtreatment?

Sara H. Javid, L. Christine Fang, Larissa Korde, and Benjamin O. Anderson

34%, 1 , 3 a favorable outcome that has been attributed to the combination of increased screening mammography and improved adjuvant therapy. 4 However, despite the steady increase in DCIS detection and treatment in the 1990s, the subsequent

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Ten Years of Progress Against Breast Cancer: A Partnership of Basic and Clinical/Translational Science

Robert W. Carlson and on behalf of the NCCN Breast Cancer Panel

-free and overall survival. 7 The effectiveness of aromatase inhibitors in the treatment of metastatic breast cancer led to a number of trials incorporating them into the adjuvant therapy of postmenopausal women with early-stage hormone receptor

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Neoadjuvant Radiotherapy Use in Locally Advanced Rectal Cancer at NCCN Member Institutions

Marsha Reyngold, Joyce Niland, Anna ter Veer, Dana Milne, Tanios Bekaii-Saab, Steven J. Cohen, Lily Lai, Deborah Schrag, John M. Skibber, William Small Jr, Martin Weiser, Neal Wilkinson, and Karyn A. Goodman

adjuvant therapy data (n=3). A total of 29 patients received postoperative RT and were excluded from the analysis of factors associated with omission of preoperative RT. The minimum follow-up time was 120 days for all patients. Variables Analyzed

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Progress in the Management of Melanoma in 2013

Daniel G. Coit and Anthony J. Olszanski

considered at high risk for recurrence after adjuvant therapy, interferon-alfa appears to confer a small benefit. The value of high-dose interferon was first established in 1996 by Kirkwood et al. 5 for patients with T4 lesions or evidence of regional

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Treatment of Early-Stage Esophageal Adenocarcinoma

Ariel Polish and Mary F. Mulcahy

neoadjuvant or adjuvant therapy. One retrospective study focused on 49 patients with adenocarcinoma (90%) or squamous (10%) cancer of the esophagus who were staged as T2,N0,M0 and received neoadjuvant chemoradiation. 14 The study found that the 5-year rates

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Costs and Benefits of Extended Endocrine Strategies for Premenopausal Breast Cancer

Janice S. Kwon, Gary Pansegrau, Melica Nourmoussavi, Geoffrey L. Hammond, and Mark S. Carey

. Goss PE Ingle JN Pritchard KI . Extending aromatase-inhibitor adjuvant therapy to 10 years . N Engl J Med 2016 ; 375 : 209 – 219 . 4. Goss PE Ingle JN Martino S . Impact of premenopausal status at breast cancer diagnosis in women entered

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Updates in the Treatment of Patients With Colorectal Cancer

Presented by: Smitha S. Krishnamurthi

just predicting a recurrence. It’s actually detecting residual disease. It appears to be the most useful prognostic assay, but there are unanswered questions, and we still don’t know if it can guide adjuvant therapy,” she said. Although ctDNA assays can

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Disparities in the Use of Neoadjuvant Therapy for Resectable Pancreatic Ductal Adenocarcinoma

Jordan M. Cloyd, Chengli Shen, Heena Santry, John Bridges, Mary Dillhoff, Aslam Ejaz, Timothy M. Pawlik, and Allan Tsung

greater number of patients will be unable to complete the intended course of adjuvant therapy for similar reasons. 7 , 8 The administration of chemotherapy with or without radiation therapy (RT) before surgical resection is an alternative strategy that

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Role of Adjuvant and Posttreatment Exercise Programs in Breast Health

Jennifer A. Ligibel

the completion of adjuvant therapy. Thus, physical activity has been shown to have several benefits for patients with breast cancer both during and after adjuvant therapy. No clear consensus exists on the “best” type of physical activity, but