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, MD • 646-888-4162 Jedd Wolchok, MD, PhD • 646-888-2395 ClinicalTrials.gov Identifier: NCT01682213 A Phase I Trial of Vorinostat Concurrent With Stereotactic Radiotherapy in Treatment of Brain Metastases From Non–Small Cell Lung Cancer

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Metastases from Solid Malignancies Principal Investigator: John C. Grecula, MD Condition: Brain metastases from solid tumors Institution: The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute

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Paul F. Engstrom, Juan Pablo Arnoletti, Al B. Benson III, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Anne Covey, Raza A. Dilawari, Dayna S. Early, Peter C. Enzinger, Marwan G. Fakih, James Fleshman Jr., Charles Fuchs, Jean L. Grem, Krystyna Kiel, James A. Knol, Lucille A. Leong, Edward Lin, Mary F. Mulcahy, Sujata Rao, David P. Ryan, Leonard Saltz, David Shibata, John M. Skibber, Constantinos Sofocleous, James Thomas, Alan P. Venook, and Christopher Willett

prognosis of TNM stage II colorectal cancer . Eur J Cancer 2005 ; 41 : 272 – 279 . 18 Newland RC Dent OF Lyttle MN . Pathologic determinants of survival associated with colorectal cancer with lymph node metastases. A multivariate analysis of

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Daniel M. Green

favorable-histology Wilms tumor (FHWT) and pulmonary metastases limited to the lungs that fail to resolve completely after an initial 5-week period of chemotherapy with the combination of vincristine/dactinomycin/doxorubicin, based on a comparison of the

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Jeffrey J. Wargo, David R. Carr, Jose A. Plaza, and Claire F. Verschraegen

magnification ×100). PET/CT revealed right-sided lung metastases and lymph node involvement in the right axilla. Based on the large size of the tumor and axillary lymphadenopathy, the outside institution opted to excise the SC with negative margins and

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Allan Lipton, Robert Uzzo, Robert J. Amato, Georgiana K. Ellis, Behrooz Hakimian, G. David Roodman, and Matthew R. Smith

. Nat Rev Cancer 2009 ; 9 : 239 – 252 . 13 Coleman RE . Skeletal complications of malignancy . Cancer 1997 ; 80 ( 8 Suppl ): 1588 – 1594 . 14 Galasko C . The anatomy and pathways of skeletal metastases . In: Weiss L Gilbert

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David Groheux, Elif Hindié, Marc Espié, and Gary A. Ulaner

that “FDG-PET/CT may…be helpful in identifying unsuspected regional nodal disease and/or distant metastases when used in addition to standard imaging studies.” In the multicenter study by Hyland et al, 1 PET/CT reduced false-positive risk by half and

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.gov Identifier: NCT00949325 A Phase I Trial of Vorinostat Concurrent with Stereotactic Radiotherapy in Treatment of Brain Metastases from Non–Small Cell Lung Cancer Principal Investigator: Griffith Harsh, MD Condition: Brain metastases, non

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R. Michael Tuttle, Douglas W. Ball, David Byrd, Raza A. Dilawari, Gerard M. Doherty, Quan-Yang Duh, Hormoz Ehya, William B. Farrar, Robert I. Haddad, Fouad Kandeel, Richard T. Kloos, Peter Kopp, Dominick M. Lamonica, Thom R. Loree, William M. Lydiatt, Judith C. McCaffrey, John A. Olson Jr., Lee Parks, John A. Ridge, Jatin P. Shah, Steven I. Sherman, Cord Sturgeon, Steven G. Waguespack, Thomas N. Wang, and Lori J. Wirth

carcinoma and up to 10% of those with follicular or Hürthle cell carcinoma have tumors that aggressively invade structures in the neck or have produced distant metastases. These cancers are difficult to cure. Recurrence of Differentiated Thyroid

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Anastasia Tararykova, Alexander Fedenko, and Elmar Musaev

Background : Giant cell tumor of bone (GCT) is a relatively rare, locally aggressive osteolytic skeletal neoplasm of young adults with uncertain behavior with recurrence rates up to 70%. Distant metastases occur approximately 2-6% of cases most